Osteoporosis management in patient with renal function impairment

Detalhes bibliográficos
Autor(a) principal: Lima,Guilherme Alcantara Cunha
Data de Publicação: 2014
Outros Autores: Paranhos Neto,Francisco de Paula, Pereira,Giselly Rosa Modesto, Gomes,Carlos Perez, Farias,Maria Lucia Fleiuss
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500530
Resumo: Aging is associated with decreases in bone quality and in glomerular filtration. Consequently, osteoporosis and chronic kidney disease (CKD) are common comorbid conditions in the elderly, and often coexist. Biochemical abnormalities in the homeostasis of calcium and phosphorus begin early in CKD, leading to an increase in fracture risk and cardiovascular complications since early stages of the disease. The ability of DXA (dual energy X-ray absorptiometry) to diagnose osteoporosis and to predict fractures in this population remains unclear. The management of the disease is also controversial: calcium and vitamin D, although recommended, must be prescribed with caution, considering vascular calcification risk and the development of adynamic bone disease. Furthermore, safety and effectiveness of osteoporosis drugs are not established in patients with CKD. Thus, risks and benefits of antiosteoporosis treatment must be considered individually.
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spelling Osteoporosis management in patient with renal function impairmentBone qualityCKD-MBDDXAfracturesosteoporosisAging is associated with decreases in bone quality and in glomerular filtration. Consequently, osteoporosis and chronic kidney disease (CKD) are common comorbid conditions in the elderly, and often coexist. Biochemical abnormalities in the homeostasis of calcium and phosphorus begin early in CKD, leading to an increase in fracture risk and cardiovascular complications since early stages of the disease. The ability of DXA (dual energy X-ray absorptiometry) to diagnose osteoporosis and to predict fractures in this population remains unclear. The management of the disease is also controversial: calcium and vitamin D, although recommended, must be prescribed with caution, considering vascular calcification risk and the development of adynamic bone disease. Furthermore, safety and effectiveness of osteoporosis drugs are not established in patients with CKD. Thus, risks and benefits of antiosteoporosis treatment must be considered individually.Sociedade Brasileira de Endocrinologia e Metabologia2014-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500530Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.5 2014reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)instacron:SBEM10.1590/0004-2730000003360info:eu-repo/semantics/openAccessLima,Guilherme Alcantara CunhaParanhos Neto,Francisco de PaulaPereira,Giselly Rosa ModestoGomes,Carlos PerezFarias,Maria Lucia Fleiusseng2014-08-19T00:00:00Zoai:scielo:S0004-27302014000500530Revistahttps://www.aem-sbem.com/ONGhttps://old.scielo.br/oai/scielo-oai.php||abem-editoria@endocrino.org.br1677-94870004-2730opendoar:2014-08-19T00:00Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)false
dc.title.none.fl_str_mv Osteoporosis management in patient with renal function impairment
title Osteoporosis management in patient with renal function impairment
spellingShingle Osteoporosis management in patient with renal function impairment
Lima,Guilherme Alcantara Cunha
Bone quality
CKD-MBD
DXA
fractures
osteoporosis
title_short Osteoporosis management in patient with renal function impairment
title_full Osteoporosis management in patient with renal function impairment
title_fullStr Osteoporosis management in patient with renal function impairment
title_full_unstemmed Osteoporosis management in patient with renal function impairment
title_sort Osteoporosis management in patient with renal function impairment
author Lima,Guilherme Alcantara Cunha
author_facet Lima,Guilherme Alcantara Cunha
Paranhos Neto,Francisco de Paula
Pereira,Giselly Rosa Modesto
Gomes,Carlos Perez
Farias,Maria Lucia Fleiuss
author_role author
author2 Paranhos Neto,Francisco de Paula
Pereira,Giselly Rosa Modesto
Gomes,Carlos Perez
Farias,Maria Lucia Fleiuss
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Lima,Guilherme Alcantara Cunha
Paranhos Neto,Francisco de Paula
Pereira,Giselly Rosa Modesto
Gomes,Carlos Perez
Farias,Maria Lucia Fleiuss
dc.subject.por.fl_str_mv Bone quality
CKD-MBD
DXA
fractures
osteoporosis
topic Bone quality
CKD-MBD
DXA
fractures
osteoporosis
description Aging is associated with decreases in bone quality and in glomerular filtration. Consequently, osteoporosis and chronic kidney disease (CKD) are common comorbid conditions in the elderly, and often coexist. Biochemical abnormalities in the homeostasis of calcium and phosphorus begin early in CKD, leading to an increase in fracture risk and cardiovascular complications since early stages of the disease. The ability of DXA (dual energy X-ray absorptiometry) to diagnose osteoporosis and to predict fractures in this population remains unclear. The management of the disease is also controversial: calcium and vitamin D, although recommended, must be prescribed with caution, considering vascular calcification risk and the development of adynamic bone disease. Furthermore, safety and effectiveness of osteoporosis drugs are not established in patients with CKD. Thus, risks and benefits of antiosteoporosis treatment must be considered individually.
publishDate 2014
dc.date.none.fl_str_mv 2014-07-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500530
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302014000500530
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0004-2730000003360
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
publisher.none.fl_str_mv Sociedade Brasileira de Endocrinologia e Metabologia
dc.source.none.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia v.58 n.5 2014
reponame:Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
instname:Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
instname_str Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron_str SBEM
institution SBEM
reponame_str Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
collection Arquivos Brasileiros de Endocrinologia & Metabologia (Online)
repository.name.fl_str_mv Arquivos Brasileiros de Endocrinologia & Metabologia (Online) - Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
repository.mail.fl_str_mv ||abem-editoria@endocrino.org.br
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