The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis

Detalhes bibliográficos
Autor(a) principal: Borggräfe, Jan
Data de Publicação: 2022
Outros Autores: Gertzen, Christoph G. W., Viegas, Aldino, Gohlke, Holger, Etzkorn, Manuel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149299
Resumo: Publisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
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spelling The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis10-23 DNAzymeDNAzymesMDNMRBiochemistryMolecular BiologyCell BiologyPublisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.Understanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNBorggräfe, JanGertzen, Christoph G. W.Viegas, AldinoGohlke, HolgerEtzkorn, Manuel2023-02-15T22:22:30Z2022-12-072022-12-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/149299eng1742-464XPURE: 53380850https://doi.org/10.1111/febs.16698info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:14Zoai:run.unl.pt:10362/149299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:42.551851Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
title The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
spellingShingle The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
Borggräfe, Jan
10-23 DNAzyme
DNAzymes
MD
NMR
Biochemistry
Molecular Biology
Cell Biology
title_short The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
title_full The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
title_fullStr The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
title_full_unstemmed The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
title_sort The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
author Borggräfe, Jan
author_facet Borggräfe, Jan
Gertzen, Christoph G. W.
Viegas, Aldino
Gohlke, Holger
Etzkorn, Manuel
author_role author
author2 Gertzen, Christoph G. W.
Viegas, Aldino
Gohlke, Holger
Etzkorn, Manuel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Borggräfe, Jan
Gertzen, Christoph G. W.
Viegas, Aldino
Gohlke, Holger
Etzkorn, Manuel
dc.subject.por.fl_str_mv 10-23 DNAzyme
DNAzymes
MD
NMR
Biochemistry
Molecular Biology
Cell Biology
topic 10-23 DNAzyme
DNAzymes
MD
NMR
Biochemistry
Molecular Biology
Cell Biology
description Publisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.
publishDate 2022
dc.date.none.fl_str_mv 2022-12-07
2022-12-07T00:00:00Z
2023-02-15T22:22:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149299
url http://hdl.handle.net/10362/149299
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1742-464X
PURE: 53380850
https://doi.org/10.1111/febs.16698
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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