The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/149299 |
Resumo: | Publisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
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The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis10-23 DNAzymeDNAzymesMDNMRBiochemistryMolecular BiologyCell BiologyPublisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.Understanding the molecular features of catalytically active DNA sequences, so-called DNAzymes, is essential not only for our understanding of the fundamental properties of catalytic nucleic acids in general, but may well be the key to unravelling their full potential via tailored modifications. Our recent findings contributed to the endeavour to assemble a mechanistic picture of DNA-mediated catalysis by providing high-resolution structural insights into the 10-23 DNAzyme (Dz) and exposing a complex interplay between the Dz's unique molecular architecture, conformational plasticity, and dynamic modulation by metal ions as central elements of the DNA catalyst. Here, we discuss key features of our findings and compare them to other studies on similar systems.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNBorggräfe, JanGertzen, Christoph G. W.Viegas, AldinoGohlke, HolgerEtzkorn, Manuel2023-02-15T22:22:30Z2022-12-072022-12-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/149299eng1742-464XPURE: 53380850https://doi.org/10.1111/febs.16698info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:14Zoai:run.unl.pt:10362/149299Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:42.551851Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
title |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
spellingShingle |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis Borggräfe, Jan 10-23 DNAzyme DNAzymes MD NMR Biochemistry Molecular Biology Cell Biology |
title_short |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
title_full |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
title_fullStr |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
title_full_unstemmed |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
title_sort |
The architecture of the 10-23 DNAzyme and its implications for DNA-mediated catalysis |
author |
Borggräfe, Jan |
author_facet |
Borggräfe, Jan Gertzen, Christoph G. W. Viegas, Aldino Gohlke, Holger Etzkorn, Manuel |
author_role |
author |
author2 |
Gertzen, Christoph G. W. Viegas, Aldino Gohlke, Holger Etzkorn, Manuel |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química RUN |
dc.contributor.author.fl_str_mv |
Borggräfe, Jan Gertzen, Christoph G. W. Viegas, Aldino Gohlke, Holger Etzkorn, Manuel |
dc.subject.por.fl_str_mv |
10-23 DNAzyme DNAzymes MD NMR Biochemistry Molecular Biology Cell Biology |
topic |
10-23 DNAzyme DNAzymes MD NMR Biochemistry Molecular Biology Cell Biology |
description |
Publisher Copyright: © 2022 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-07 2022-12-07T00:00:00Z 2023-02-15T22:22:30Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/149299 |
url |
http://hdl.handle.net/10362/149299 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1742-464X PURE: 53380850 https://doi.org/10.1111/febs.16698 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799138127288205312 |