Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/141854 |
Resumo: | This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies. |
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Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reactioncrosslinkinggelspoly(ethylene glycol)sensorsUgi reactionChemistry(all)This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies.The four-component Ugi condensation reaction has been investigated to assemble chemically crosslinked hydrogels using multivalent star-shaped poly(ethylene glycol) components. The resulting biocompatible hydrogels are highly versatile in composition and function. It is shown that acid, aldehyde, and cyanide components can be varied yielding materials with precise structure and tunable stiffness. Additionally, the resulting hydrogels were proven extremely robust to consecutive drying-swelling cycles. This property was explored to develop a reversible humidity colorimetric sensor gel. Overall, this work demonstrates the application of the four-component Ugi reaction as a powerful tool to quickly generate crosslinked gels with precise control in chemical composition.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNPadrão, InêsFernandes, Cláudia S. M.Esteves, CarinaFernandes, TiagoPina, Ana S.Roque, Ana Cecília A.2022-07-13T22:22:36Z2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://hdl.handle.net/10362/141854eng2192-6506PURE: 27893747https://doi.org/10.1002/cplu.202000743info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:03:27Zoai:run.unl.pt:10362/141854Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:03:27Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
title |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
spellingShingle |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction Padrão, Inês crosslinking gels poly(ethylene glycol) sensors Ugi reaction Chemistry(all) |
title_short |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
title_full |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
title_fullStr |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
title_full_unstemmed |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
title_sort |
Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction |
author |
Padrão, Inês |
author_facet |
Padrão, Inês Fernandes, Cláudia S. M. Esteves, Carina Fernandes, Tiago Pina, Ana S. Roque, Ana Cecília A. |
author_role |
author |
author2 |
Fernandes, Cláudia S. M. Esteves, Carina Fernandes, Tiago Pina, Ana S. Roque, Ana Cecília A. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
UCIBIO - Applied Molecular Biosciences Unit DQ - Departamento de Química RUN |
dc.contributor.author.fl_str_mv |
Padrão, Inês Fernandes, Cláudia S. M. Esteves, Carina Fernandes, Tiago Pina, Ana S. Roque, Ana Cecília A. |
dc.subject.por.fl_str_mv |
crosslinking gels poly(ethylene glycol) sensors Ugi reaction Chemistry(all) |
topic |
crosslinking gels poly(ethylene glycol) sensors Ugi reaction Chemistry(all) |
description |
This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 2020-12-01T00:00:00Z 2022-07-13T22:22:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/141854 |
url |
http://hdl.handle.net/10362/141854 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2192-6506 PURE: 27893747 https://doi.org/10.1002/cplu.202000743 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
5 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817545874694209536 |