Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction

Detalhes bibliográficos
Autor(a) principal: Padrão, Inês
Data de Publicação: 2020
Outros Autores: Fernandes, Cláudia S. M., Esteves, Carina, Fernandes, Tiago, Pina, Ana S., Roque, Ana Cecília A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/141854
Resumo: This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies.
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spelling Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reactioncrosslinkinggelspoly(ethylene glycol)sensorsUgi reactionChemistry(all)This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies.The four-component Ugi condensation reaction has been investigated to assemble chemically crosslinked hydrogels using multivalent star-shaped poly(ethylene glycol) components. The resulting biocompatible hydrogels are highly versatile in composition and function. It is shown that acid, aldehyde, and cyanide components can be varied yielding materials with precise structure and tunable stiffness. Additionally, the resulting hydrogels were proven extremely robust to consecutive drying-swelling cycles. This property was explored to develop a reversible humidity colorimetric sensor gel. Overall, this work demonstrates the application of the four-component Ugi reaction as a powerful tool to quickly generate crosslinked gels with precise control in chemical composition.UCIBIO - Applied Molecular Biosciences UnitDQ - Departamento de QuímicaRUNPadrão, InêsFernandes, Cláudia S. M.Esteves, CarinaFernandes, TiagoPina, Ana S.Roque, Ana Cecília A.2022-07-13T22:22:36Z2020-122020-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5application/pdfhttp://hdl.handle.net/10362/141854eng2192-6506PURE: 27893747https://doi.org/10.1002/cplu.202000743info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:03:27Zoai:run.unl.pt:10362/141854Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:03:27Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
title Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
spellingShingle Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
Padrão, Inês
crosslinking
gels
poly(ethylene glycol)
sensors
Ugi reaction
Chemistry(all)
title_short Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
title_full Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
title_fullStr Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
title_full_unstemmed Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
title_sort Versatile and Tunable Poly(Ethylene Glycol)-Based Hydrogels Crosslinked through the Ugi Reaction
author Padrão, Inês
author_facet Padrão, Inês
Fernandes, Cláudia S. M.
Esteves, Carina
Fernandes, Tiago
Pina, Ana S.
Roque, Ana Cecília A.
author_role author
author2 Fernandes, Cláudia S. M.
Esteves, Carina
Fernandes, Tiago
Pina, Ana S.
Roque, Ana Cecília A.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
DQ - Departamento de Química
RUN
dc.contributor.author.fl_str_mv Padrão, Inês
Fernandes, Cláudia S. M.
Esteves, Carina
Fernandes, Tiago
Pina, Ana S.
Roque, Ana Cecília A.
dc.subject.por.fl_str_mv crosslinking
gels
poly(ethylene glycol)
sensors
Ugi reaction
Chemistry(all)
topic crosslinking
gels
poly(ethylene glycol)
sensors
Ugi reaction
Chemistry(all)
description This work was supported by the Applied Molecular Bioscience Unit – UCIBIO (UIDB/04378/2020); projects PTDC/BII‐BIO/28878/2017 (LISBOA‐01‐0145‐FEDER‐028878); PTDC/SAL‐SER/30388/2017 (POCI‐01‐0145‐FEDER‐030388); Ph.D. fellowships to CF (PD/BD/105871/2014); CE (SFRH/BD/113112/2015). The authors are grateful to Prof. Ana Rita C. Duarte from Associate Laboratory for Green Chemistry – LAQV, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa for facilitating the rheology studies.
publishDate 2020
dc.date.none.fl_str_mv 2020-12
2020-12-01T00:00:00Z
2022-07-13T22:22:36Z
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url http://hdl.handle.net/10362/141854
dc.language.iso.fl_str_mv eng
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PURE: 27893747
https://doi.org/10.1002/cplu.202000743
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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