Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules

Detalhes bibliográficos
Autor(a) principal: Pereira, Luís
Data de Publicação: 2023
Outros Autores: Ferreira, Frederico Castelo, Pires, Filipa, Portugal, Carla A. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/159766
Resumo: The authors acknowledge the financial support from Fundação para a Ciência e a Tecnologia (FCT-MEC), Portugal, through the dedicated project (PTDC/EDM-EDM/30828/2017) (BeLive) Publisher Copyright: © 2023 by the authors.
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spelling Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive MoleculesAn Insight into the Release Kineticsdrug release kineticsliposomesmagnetic fieldChemical Engineering (miscellaneous)Process Chemistry and TechnologyFiltration and SeparationThe authors acknowledge the financial support from Fundação para a Ciência e a Tecnologia (FCT-MEC), Portugal, through the dedicated project (PTDC/EDM-EDM/30828/2017) (BeLive) Publisher Copyright: © 2023 by the authors.This work explores the unique features of magnetic-responsive hydrogels to obtain liposomal hydrogel delivery platforms capable of precise magnetically modulated drug release based on the mechanical responses of these hydrogels when exposed to an external magnetic field. Magnetic-responsive liposomal hydrogel delivery systems were prepared by encapsulation of 1,2-dipalmitoyl-sn-glycero-3-phosphocoline (DPPC) multilayered vesicles (MLVs) loaded with ferulic acid (FA), i.e., DPPC:FA liposomes, into gelatin hydrogel membranes containing dispersed iron oxide nanoparticles (MNPs), i.e., magnetic-responsive gelatin. The FA release mechanisms and kinetics from magnetic-responsive liposomal gelatin were studied and compared with those obtained with conventional drug delivery systems, e.g., free liposomal suspensions and hydrogel matrices, to access the effect of liposome entrapment and magnetic field on FA delivery. FA release from liposomal gelatin membranes was well described by the Korsmeyer–Peppas model, indicating that FA release occurred under a controlled diffusional regime, with or without magnetic stimulation. DPPC:FA liposomal gelatin systems provided smoother controlled FA release, relative to that obtained with the liposome suspensions and with the hydrogel platforms, suggesting the promising application of liposomal hydrogel systems in longer-term therapeutics. The magnetic field, with low intensity (0.08 T), was found to stimulate the FA release from magnetic-responsive liposomal gelatin systems, increasing the release rates while shifting the FA release to a quasi-Fickian mechanism. The magnetic-responsive liposomal hydrogels developed in this work offer the possibility to magnetically activate drug release from these liposomal platforms based on a non-thermal related delivery strategy, paving the way for the development of novel and more efficient applications of MLVs and liposomal delivery systems in biomedicine.DQ - Departamento de QuímicaLAQV@REQUIMTERUNPereira, LuísFerreira, Frederico CasteloPires, FilipaPortugal, Carla A. M.2023-11-09T22:09:24Z2023-07-172023-07-17T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article28application/pdfhttp://hdl.handle.net/10362/159766eng0076-6356PURE: 75761453https://doi.org/10.3390/membranes13070674info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:42:14Zoai:run.unl.pt:10362/159766Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:57:41.964097Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
An Insight into the Release Kinetics
title Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
spellingShingle Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
Pereira, Luís
drug release kinetics
liposomes
magnetic field
Chemical Engineering (miscellaneous)
Process Chemistry and Technology
Filtration and Separation
title_short Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
title_full Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
title_fullStr Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
title_full_unstemmed Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
title_sort Magnetic-Responsive Liposomal Hydrogel Membranes for Controlled Release of Small Bioactive Molecules
author Pereira, Luís
author_facet Pereira, Luís
Ferreira, Frederico Castelo
Pires, Filipa
Portugal, Carla A. M.
author_role author
author2 Ferreira, Frederico Castelo
Pires, Filipa
Portugal, Carla A. M.
author2_role author
author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Pereira, Luís
Ferreira, Frederico Castelo
Pires, Filipa
Portugal, Carla A. M.
dc.subject.por.fl_str_mv drug release kinetics
liposomes
magnetic field
Chemical Engineering (miscellaneous)
Process Chemistry and Technology
Filtration and Separation
topic drug release kinetics
liposomes
magnetic field
Chemical Engineering (miscellaneous)
Process Chemistry and Technology
Filtration and Separation
description The authors acknowledge the financial support from Fundação para a Ciência e a Tecnologia (FCT-MEC), Portugal, through the dedicated project (PTDC/EDM-EDM/30828/2017) (BeLive) Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-11-09T22:09:24Z
2023-07-17
2023-07-17T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/159766
url http://hdl.handle.net/10362/159766
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0076-6356
PURE: 75761453
https://doi.org/10.3390/membranes13070674
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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