Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2003 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Hospital das Clínicas |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300005 |
Resumo: | OBJECTIVE: To investigate the frequencies and behavior of antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus. METHODS: Anticardiolipin antibodies were investigated by ELISA and lupus anticoagulant antibodies by the international tests recommended. The antiphospholipid antibodies analyses were performed in frozen samples (mean of 5.3 samples per patient obtained during a mean follow-up period of 3 years and 7 months) and on blood samples collected between January 1997 and November 1998 (mean of 2.5 samples per patient during a 2-year follow-up period). RESULTS: The frequencies of antiphospholipid antibodies (anticardiolipin and lupus anticoagulant) were similar in the samples collected prospectively and in the frozen samples (retrospective study): 63.2% and 75.4% respectively. Positivity for these antibodies fluctuated during the follow-up period and was not associated with any clinical or laboratory parameters of lupus erythematosus, including autoantibodies and also including disease activity and/or severity scores. CONCLUSIONS: The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters. |
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USP-57 |
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Revista do Hospital das Clínicas |
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Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosusAntiphospholipid antibodiesChildrenSystemic lupus erythematosusOBJECTIVE: To investigate the frequencies and behavior of antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus. METHODS: Anticardiolipin antibodies were investigated by ELISA and lupus anticoagulant antibodies by the international tests recommended. The antiphospholipid antibodies analyses were performed in frozen samples (mean of 5.3 samples per patient obtained during a mean follow-up period of 3 years and 7 months) and on blood samples collected between January 1997 and November 1998 (mean of 2.5 samples per patient during a 2-year follow-up period). RESULTS: The frequencies of antiphospholipid antibodies (anticardiolipin and lupus anticoagulant) were similar in the samples collected prospectively and in the frozen samples (retrospective study): 63.2% and 75.4% respectively. Positivity for these antibodies fluctuated during the follow-up period and was not associated with any clinical or laboratory parameters of lupus erythematosus, including autoantibodies and also including disease activity and/or severity scores. CONCLUSIONS: The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters.Faculdade de Medicina / Universidade de São Paulo - FM/USP2003-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300005Revista do Hospital das Clínicas v.58 n.3 2003reponame:Revista do Hospital das Clínicasinstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0041-87812003000300005info:eu-repo/semantics/openAccessCampos,Lúcia Maria de ArrudaKiss,Maria Helena B.D'Amico,Élbio A.Silva,Clóvis Artur Almeidaeng2003-07-22T00:00:00Zoai:scielo:S0041-87812003000300005Revistahttp://www.scielo.br/rhcPUBhttps://old.scielo.br/oai/scielo-oai.php||revista.hc@hcnet.usp.br1678-99030041-8781opendoar:2003-07-22T00:00Revista do Hospital das Clínicas - Universidade de São Paulo (USP)false |
dc.title.none.fl_str_mv |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
title |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
spellingShingle |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus Campos,Lúcia Maria de Arruda Antiphospholipid antibodies Children Systemic lupus erythematosus |
title_short |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
title_full |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
title_fullStr |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
title_full_unstemmed |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
title_sort |
Antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus |
author |
Campos,Lúcia Maria de Arruda |
author_facet |
Campos,Lúcia Maria de Arruda Kiss,Maria Helena B. D'Amico,Élbio A. Silva,Clóvis Artur Almeida |
author_role |
author |
author2 |
Kiss,Maria Helena B. D'Amico,Élbio A. Silva,Clóvis Artur Almeida |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Campos,Lúcia Maria de Arruda Kiss,Maria Helena B. D'Amico,Élbio A. Silva,Clóvis Artur Almeida |
dc.subject.por.fl_str_mv |
Antiphospholipid antibodies Children Systemic lupus erythematosus |
topic |
Antiphospholipid antibodies Children Systemic lupus erythematosus |
description |
OBJECTIVE: To investigate the frequencies and behavior of antiphospholipid antibodies in 57 children and adolescents with systemic lupus erythematosus. METHODS: Anticardiolipin antibodies were investigated by ELISA and lupus anticoagulant antibodies by the international tests recommended. The antiphospholipid antibodies analyses were performed in frozen samples (mean of 5.3 samples per patient obtained during a mean follow-up period of 3 years and 7 months) and on blood samples collected between January 1997 and November 1998 (mean of 2.5 samples per patient during a 2-year follow-up period). RESULTS: The frequencies of antiphospholipid antibodies (anticardiolipin and lupus anticoagulant) were similar in the samples collected prospectively and in the frozen samples (retrospective study): 63.2% and 75.4% respectively. Positivity for these antibodies fluctuated during the follow-up period and was not associated with any clinical or laboratory parameters of lupus erythematosus, including autoantibodies and also including disease activity and/or severity scores. CONCLUSIONS: The frequencies of antiphospholipid antibodies in children and adolescents with lupus erythematosus were similar to those observed in adults. The positivity fluctuated during the follow-up and was not correlated with clinical and/or laboratory disease parameters. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0041-87812003000300005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0041-87812003000300005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
publisher.none.fl_str_mv |
Faculdade de Medicina / Universidade de São Paulo - FM/USP |
dc.source.none.fl_str_mv |
Revista do Hospital das Clínicas v.58 n.3 2003 reponame:Revista do Hospital das Clínicas instname:Universidade de São Paulo (USP) instacron:USP |
instname_str |
Universidade de São Paulo (USP) |
instacron_str |
USP |
institution |
USP |
reponame_str |
Revista do Hospital das Clínicas |
collection |
Revista do Hospital das Clínicas |
repository.name.fl_str_mv |
Revista do Hospital das Clínicas - Universidade de São Paulo (USP) |
repository.mail.fl_str_mv |
||revista.hc@hcnet.usp.br |
_version_ |
1754820894544363520 |