Permeation of skin with (C60) fullerene dispersions

Detalhes bibliográficos
Autor(a) principal: Sá, M.
Data de Publicação: 2017
Outros Autores: Azóia, Nuno G., Melle-Franco, Manuel, Ribeiro, Artur, Cavaco-Paulo, Artur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/46390
Resumo: Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/ isopropyl myristate without harsh organic solvents show a high potential for delivery of C60 for biopharmaceutical and cosmetics applications.
id RCAP_a0777597d04ad470fdbc5781881b08d3
oai_identifier_str oai:repositorium.sdum.uminho.pt:1822/46390
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Permeation of skin with (C60) fullerene dispersionsDeliveryDispersionFullerene C60TransdermalCosmeticsScience & TechnologyDispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/ isopropyl myristate without harsh organic solvents show a high potential for delivery of C60 for biopharmaceutical and cosmetics applications.This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI01-0145-FEDER-006684).). Artur Ribeiro thanks FCT for the SFRH\BPD\98388\2013 grant.info:eu-repo/semantics/publishedVersionWiley-BlackwellUniversidade do MinhoSá, M.Azóia, Nuno G.Melle-Franco, ManuelRibeiro, ArturCavaco-Paulo, Artur2017-072017-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/46390engSá, M.; Azoia, Nuno G.; Melle-Franco, Manuel; Ribeiro, Artur; Cavaco-Paulo, Artur, Permeation of skin with (C60) fullerene dispersions. Engineering in Life Sciences, 17(7), 732-738, 20171618-02401618-286310.1002/elsc.201600244http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1618-2863info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-11T07:00:03Zoai:repositorium.sdum.uminho.pt:1822/46390Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-11T07:00:03Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Permeation of skin with (C60) fullerene dispersions
title Permeation of skin with (C60) fullerene dispersions
spellingShingle Permeation of skin with (C60) fullerene dispersions
Sá, M.
Delivery
Dispersion
Fullerene C60
Transdermal
Cosmetics
Science & Technology
title_short Permeation of skin with (C60) fullerene dispersions
title_full Permeation of skin with (C60) fullerene dispersions
title_fullStr Permeation of skin with (C60) fullerene dispersions
title_full_unstemmed Permeation of skin with (C60) fullerene dispersions
title_sort Permeation of skin with (C60) fullerene dispersions
author Sá, M.
author_facet Sá, M.
Azóia, Nuno G.
Melle-Franco, Manuel
Ribeiro, Artur
Cavaco-Paulo, Artur
author_role author
author2 Azóia, Nuno G.
Melle-Franco, Manuel
Ribeiro, Artur
Cavaco-Paulo, Artur
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Sá, M.
Azóia, Nuno G.
Melle-Franco, Manuel
Ribeiro, Artur
Cavaco-Paulo, Artur
dc.subject.por.fl_str_mv Delivery
Dispersion
Fullerene C60
Transdermal
Cosmetics
Science & Technology
topic Delivery
Dispersion
Fullerene C60
Transdermal
Cosmetics
Science & Technology
description Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/ isopropyl myristate without harsh organic solvents show a high potential for delivery of C60 for biopharmaceutical and cosmetics applications.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
2017-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/46390
url http://hdl.handle.net/1822/46390
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Sá, M.; Azoia, Nuno G.; Melle-Franco, Manuel; Ribeiro, Artur; Cavaco-Paulo, Artur, Permeation of skin with (C60) fullerene dispersions. Engineering in Life Sciences, 17(7), 732-738, 2017
1618-0240
1618-2863
10.1002/elsc.201600244
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1618-2863
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley-Blackwell
publisher.none.fl_str_mv Wiley-Blackwell
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545166798454784

Registros relacionados