The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years

Detalhes bibliográficos
Autor(a) principal: Gomes, Ana
Data de Publicação: 2021
Outros Autores: Aguiar, Luísa, Ferraz, Ricardo, Teixeira, Cátia, Gomes, Paula
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.22/19137
Resumo: Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.
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spelling The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of yearsActive pharmaceutical ingredientsComplicated skin and soft tissue infectionsCosmeticsIonic liquidsPeptidesTransdermal deliveryWound-healingTopical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.MDPIRepositório Científico do Instituto Politécnico do PortoGomes, AnaAguiar, LuísaFerraz, RicardoTeixeira, CátiaGomes, Paula2021-12-17T14:25:17Z2021-11-052021-11-05T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.22/19137engGomes, A., Aguiar, L., Ferraz, R., Teixeira, C., & Gomes, P. (2021). The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years. International Journal of Molecular Sciences, 22(21), 11991. https://www.mdpi.com/1422-0067/22/21/1199110.3390/ijms2221119911422-0067info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-13T13:12:57Zoai:recipp.ipp.pt:10400.22/19137Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:39:11.288672Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
title The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
spellingShingle The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
Gomes, Ana
Active pharmaceutical ingredients
Complicated skin and soft tissue infections
Cosmetics
Ionic liquids
Peptides
Transdermal delivery
Wound-healing
title_short The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
title_full The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
title_fullStr The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
title_full_unstemmed The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
title_sort The emerging role of ionic liquid-based approaches for enhanced skin permeation of bioactive molecules: a snapshot of the past couple of years
author Gomes, Ana
author_facet Gomes, Ana
Aguiar, Luísa
Ferraz, Ricardo
Teixeira, Cátia
Gomes, Paula
author_role author
author2 Aguiar, Luísa
Ferraz, Ricardo
Teixeira, Cátia
Gomes, Paula
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Politécnico do Porto
dc.contributor.author.fl_str_mv Gomes, Ana
Aguiar, Luísa
Ferraz, Ricardo
Teixeira, Cátia
Gomes, Paula
dc.subject.por.fl_str_mv Active pharmaceutical ingredients
Complicated skin and soft tissue infections
Cosmetics
Ionic liquids
Peptides
Transdermal delivery
Wound-healing
topic Active pharmaceutical ingredients
Complicated skin and soft tissue infections
Cosmetics
Ionic liquids
Peptides
Transdermal delivery
Wound-healing
description Topical and transdermal delivery systems are of undeniable significance and ubiquity in healthcare, to facilitate the delivery of active pharmaceutical ingredients, respectively, onto or across the skin to enter systemic circulation. From ancient ointments and potions to modern micro/nanotechnological devices, a variety of approaches has been explored over the ages to improve the skin permeation of diverse medicines and cosmetics. Amongst the latest investigational dermal permeation enhancers, ionic liquids have been gaining momentum, and recent years have been prolific in this regard. As such, this review offers an outline of current methods for enhancing percutaneous permeation, highlighting selected reports where ionic liquid-based approaches have been investigated for this purpose. Future perspectives on use of ionic liquids for topical delivery of bioactive peptides are also presented.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-17T14:25:17Z
2021-11-05
2021-11-05T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.22/19137
url http://hdl.handle.net/10400.22/19137
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Gomes, A., Aguiar, L., Ferraz, R., Teixeira, C., & Gomes, P. (2021). The Emerging Role of Ionic Liquid-Based Approaches for Enhanced Skin Permeation of Bioactive Molecules: A Snapshot of the Past Couple of Years. International Journal of Molecular Sciences, 22(21), 11991. https://www.mdpi.com/1422-0067/22/21/11991
10.3390/ijms222111991
1422-0067
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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