Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis

Detalhes bibliográficos
Autor(a) principal: Torres, T.
Data de Publicação: 2014
Outros Autores: Bettencourt, N., Ferreira, J., Carvalho, C., Mendonça, D., Pinho-Costa, P., Vasconcelos, C., Selores, M., Silva, B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/2870
Resumo: Research letter
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spelling Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasisIL-6 gene PolymorphismsEpicardial Adipose TissuePsoriasisDoenças GenéticasResearch letterPsoriasis is currently considered a systemic inflammatory disorder associated with several comorbidities and increased risk of cardiovascular disease (CVD)1 cytokines are overexpressed cutaneous and systemically and may be responsible for skin lesions but also for psoriasis-associated conditions surrounding the heart, is now regarded as an important factor in the pathogenesis of coronary atherosclerosis and CVD, through inflammatory burden proximal to the coronary arteries, and has been shown to be increased in psoriasis patients independently of abdominal visceral fat (AVF) and to be associated with sub-clinical atherosclerosis IL-6 has been implicated in the pathogenesis of psoriasis1 but also of abdominal obesity atherosclerosis and CVD4 30% of total circulating concentrations in healthy subjects thought to be influenced by polymorphisms in their gene loci, and this may contribute to the development of psoriasis, but also excess adiposity and psoriasis has been investigated that could predict which patients are at risk of developing psoriasis-linked cardiovascular comorbidities may permit an earlier management, with important clinical implications. This study aimed to evaluate the potential contribution of four IL-6 genetic variants (rs1800795[-174G>C], rs1800796[-572G>C], rs2069827[-1426G>T], rs2069840[-1753C>G]) in psoriasis susceptibility and its influence in EAT and coronary artery calcification (CAC) in severe psoriasis patients.Wiley/ British Association of DermatologistsRepositório Científico do Instituto Nacional de SaúdeTorres, T.Bettencourt, N.Ferreira, J.Carvalho, C.Mendonça, D.Pinho-Costa, P.Vasconcelos, C.Selores, M.Silva, B.2015-02-17T13:32:19Z2014-12-302014-12-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/2870engBr J Dermatol. 2015 Feb;172(2):534-6. doi: 10.1111/bjd.13271. Epub 2014 Dec 300007-096310.1111/bjd.13271info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:30Zoai:repositorio.insa.pt:10400.18/2870Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:37:52.085912Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
title Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
spellingShingle Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
Torres, T.
IL-6 gene Polymorphisms
Epicardial Adipose Tissue
Psoriasis
Doenças Genéticas
title_short Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
title_full Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
title_fullStr Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
title_full_unstemmed Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
title_sort Influence of interleukin-6 gene polymorphisms in epicardial adipose tissue and coronary artery calcification in patients with psoriasis
author Torres, T.
author_facet Torres, T.
Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonça, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
author_role author
author2 Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonça, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Torres, T.
Bettencourt, N.
Ferreira, J.
Carvalho, C.
Mendonça, D.
Pinho-Costa, P.
Vasconcelos, C.
Selores, M.
Silva, B.
dc.subject.por.fl_str_mv IL-6 gene Polymorphisms
Epicardial Adipose Tissue
Psoriasis
Doenças Genéticas
topic IL-6 gene Polymorphisms
Epicardial Adipose Tissue
Psoriasis
Doenças Genéticas
description Research letter
publishDate 2014
dc.date.none.fl_str_mv 2014-12-30
2014-12-30T00:00:00Z
2015-02-17T13:32:19Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/2870
url http://hdl.handle.net/10400.18/2870
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Br J Dermatol. 2015 Feb;172(2):534-6. doi: 10.1111/bjd.13271. Epub 2014 Dec 30
0007-0963
10.1111/bjd.13271
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley/ British Association of Dermatologists
publisher.none.fl_str_mv Wiley/ British Association of Dermatologists
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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