MERS coronavirus: data gaps for laboratory preparedness

Detalhes bibliográficos
Autor(a) principal: de Sousa, Rita
Data de Publicação: 2014
Outros Autores: Reusken, Chantal, Koopmans, Marion
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/3760
Resumo: Review
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spelling MERS coronavirus: data gaps for laboratory preparednessInfecções Sistémicas e ZoonosesCoronavirusLaboratory PreparednessMiddle East Respiratory Syndrome CoronavirusSARSReviewSince the emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, many questions remain on modes of transmission and sources of virus. In outbreak situations, especially with emerging organisms causing severe human disease, it is important to understand the full spectrum of disease, and shedding kinetics in relation to infectivity and the ability to transmit the microorganism. Laboratory response capacity during the early stages of an outbreak focuses on development of virological and immunological methods for patient diagnosis, for contact tracing, and for epidemiological studies into sources, modes of transmission, identification of risk groups, and animal reservoirs. However, optimal use of this core public health laboratory capacity requires a fundamental understanding of kinetics of viral shedding and antibody response, of assay validation and of interpretation of test outcomes. We reviewed available data from MERS-CoV case reports, and compared this with data on kinetics of shedding and immune response from published literature on other human coronaviruses (hCoVs). We identify and discuss important data gaps, and biases that limit the laboratory preparedness to this novel disease. Public health management will benefit from standardised reporting of methods used, details of test outcomes by sample type, sampling date, in relation to symptoms and risk factors, along with the currently reported demographic, clinical and epidemiological findings.RS was funded by the European Public Health Training Program (Euphem), ECDC, Stockholm. RIVM is partner in the ECDC sponsored outbreak assistance laboratory network ENIVD (European Network for Diagnostics of ‘Imported’ Viral Diseases) Contract Ref. No. ECDC/2013/012.Elsevier/European Society for Clinical VirologyRepositório Científico do Instituto Nacional de Saúdede Sousa, RitaReusken, ChantalKoopmans, Marion2018-02-01T01:30:09Z2014-012014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3760engJ Clin Virol. 2014 Jan;59(1):4-11. doi: 10.1016/j.jcv.2013.10.030. Epub 2013 Nov 7.1386-653210.1016/j.jcv.2013.10.030.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:56Zoai:repositorio.insa.pt:10400.18/3760Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:33.040501Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv MERS coronavirus: data gaps for laboratory preparedness
title MERS coronavirus: data gaps for laboratory preparedness
spellingShingle MERS coronavirus: data gaps for laboratory preparedness
de Sousa, Rita
Infecções Sistémicas e Zoonoses
Coronavirus
Laboratory Preparedness
Middle East Respiratory Syndrome Coronavirus
SARS
title_short MERS coronavirus: data gaps for laboratory preparedness
title_full MERS coronavirus: data gaps for laboratory preparedness
title_fullStr MERS coronavirus: data gaps for laboratory preparedness
title_full_unstemmed MERS coronavirus: data gaps for laboratory preparedness
title_sort MERS coronavirus: data gaps for laboratory preparedness
author de Sousa, Rita
author_facet de Sousa, Rita
Reusken, Chantal
Koopmans, Marion
author_role author
author2 Reusken, Chantal
Koopmans, Marion
author2_role author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv de Sousa, Rita
Reusken, Chantal
Koopmans, Marion
dc.subject.por.fl_str_mv Infecções Sistémicas e Zoonoses
Coronavirus
Laboratory Preparedness
Middle East Respiratory Syndrome Coronavirus
SARS
topic Infecções Sistémicas e Zoonoses
Coronavirus
Laboratory Preparedness
Middle East Respiratory Syndrome Coronavirus
SARS
description Review
publishDate 2014
dc.date.none.fl_str_mv 2014-01
2014-01-01T00:00:00Z
2018-02-01T01:30:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/3760
url http://hdl.handle.net/10400.18/3760
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Clin Virol. 2014 Jan;59(1):4-11. doi: 10.1016/j.jcv.2013.10.030. Epub 2013 Nov 7.
1386-6532
10.1016/j.jcv.2013.10.030.
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
eu_rights_str_mv embargoedAccess
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dc.publisher.none.fl_str_mv Elsevier/European Society for Clinical Virology
publisher.none.fl_str_mv Elsevier/European Society for Clinical Virology
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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