MERS coronavirus: data gaps for laboratory preparedness
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/3760 |
Resumo: | Review |
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7160 |
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MERS coronavirus: data gaps for laboratory preparednessInfecções Sistémicas e ZoonosesCoronavirusLaboratory PreparednessMiddle East Respiratory Syndrome CoronavirusSARSReviewSince the emergence of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) in 2012, many questions remain on modes of transmission and sources of virus. In outbreak situations, especially with emerging organisms causing severe human disease, it is important to understand the full spectrum of disease, and shedding kinetics in relation to infectivity and the ability to transmit the microorganism. Laboratory response capacity during the early stages of an outbreak focuses on development of virological and immunological methods for patient diagnosis, for contact tracing, and for epidemiological studies into sources, modes of transmission, identification of risk groups, and animal reservoirs. However, optimal use of this core public health laboratory capacity requires a fundamental understanding of kinetics of viral shedding and antibody response, of assay validation and of interpretation of test outcomes. We reviewed available data from MERS-CoV case reports, and compared this with data on kinetics of shedding and immune response from published literature on other human coronaviruses (hCoVs). We identify and discuss important data gaps, and biases that limit the laboratory preparedness to this novel disease. Public health management will benefit from standardised reporting of methods used, details of test outcomes by sample type, sampling date, in relation to symptoms and risk factors, along with the currently reported demographic, clinical and epidemiological findings.RS was funded by the European Public Health Training Program (Euphem), ECDC, Stockholm. RIVM is partner in the ECDC sponsored outbreak assistance laboratory network ENIVD (European Network for Diagnostics of ‘Imported’ Viral Diseases) Contract Ref. No. ECDC/2013/012.Elsevier/European Society for Clinical VirologyRepositório Científico do Instituto Nacional de Saúdede Sousa, RitaReusken, ChantalKoopmans, Marion2018-02-01T01:30:09Z2014-012014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/3760engJ Clin Virol. 2014 Jan;59(1):4-11. doi: 10.1016/j.jcv.2013.10.030. Epub 2013 Nov 7.1386-653210.1016/j.jcv.2013.10.030.info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:39:56Zoai:repositorio.insa.pt:10400.18/3760Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:38:33.040501Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
MERS coronavirus: data gaps for laboratory preparedness |
title |
MERS coronavirus: data gaps for laboratory preparedness |
spellingShingle |
MERS coronavirus: data gaps for laboratory preparedness de Sousa, Rita Infecções Sistémicas e Zoonoses Coronavirus Laboratory Preparedness Middle East Respiratory Syndrome Coronavirus SARS |
title_short |
MERS coronavirus: data gaps for laboratory preparedness |
title_full |
MERS coronavirus: data gaps for laboratory preparedness |
title_fullStr |
MERS coronavirus: data gaps for laboratory preparedness |
title_full_unstemmed |
MERS coronavirus: data gaps for laboratory preparedness |
title_sort |
MERS coronavirus: data gaps for laboratory preparedness |
author |
de Sousa, Rita |
author_facet |
de Sousa, Rita Reusken, Chantal Koopmans, Marion |
author_role |
author |
author2 |
Reusken, Chantal Koopmans, Marion |
author2_role |
author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
de Sousa, Rita Reusken, Chantal Koopmans, Marion |
dc.subject.por.fl_str_mv |
Infecções Sistémicas e Zoonoses Coronavirus Laboratory Preparedness Middle East Respiratory Syndrome Coronavirus SARS |
topic |
Infecções Sistémicas e Zoonoses Coronavirus Laboratory Preparedness Middle East Respiratory Syndrome Coronavirus SARS |
description |
Review |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-01 2014-01-01T00:00:00Z 2018-02-01T01:30:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/3760 |
url |
http://hdl.handle.net/10400.18/3760 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Clin Virol. 2014 Jan;59(1):4-11. doi: 10.1016/j.jcv.2013.10.030. Epub 2013 Nov 7. 1386-6532 10.1016/j.jcv.2013.10.030. |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/European Society for Clinical Virology |
publisher.none.fl_str_mv |
Elsevier/European Society for Clinical Virology |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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