The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/154978 |
Resumo: | Funding Information: The authors thank the Coordination for the Improvement of Higher Education Personnel (CAPES) and the National Council for Scientific and Technological Development (CNPq) for their financial support. This study was supported by the CAPES — number 88887.505029/2020–00 . Cecilia Gomes Barbosa receives a scholarship funded by CAPES — number 88887.643352/2021–00 . Publisher Copyright: © 2023 Elsevier B.V. |
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The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinoneAnti-SARS-CoV-2Antichagasic activityInclusion complexesNaphthoquinoneRM Therapeutics. PharmacologyQR355 VirologyQR MicrobiologyRA Public aspects of medicineRA0421 Public health. Hygiene. Preventive MedicineInfectious DiseasesPharmaceutical ScienceBiochemistry, Genetics and Molecular Biology (miscellaneous)ParasitologyVirologySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: The authors thank the Coordination for the Improvement of Higher Education Personnel (CAPES) and the National Council for Scientific and Technological Development (CNPq) for their financial support. This study was supported by the CAPES — number 88887.505029/2020–00 . Cecilia Gomes Barbosa receives a scholarship funded by CAPES — number 88887.643352/2021–00 . Publisher Copyright: © 2023 Elsevier B.V.The compound 3a,10b-dihydro-1H-cyclopenta[b]naphtho[2,3-d]furan-5,10-dione (IVS320) is a naphthoquinone with antifungal and antichagasic potential, which however has low aqueous solubility. To increase bioavailability, inclusion complexes with β-cyclodextrin (βCD) and methyl-β-cyclodextrin (MβCD) were prepared by physical mixture (PM), kneading (KN) and rotary evaporation (RE), and their in vitro anti-SARS-CoV-2 and antichagasic potential was assessed. The formation of inclusion complexes led to a change in the physicochemical characteristics compared to IVS320 alone as well as a decrease in crystallinity degree that reached 74.44% for the IVS320-MβCD one prepared by RE. The IVS320 and IVS320-MβCD/RE system exhibited anti-SARS-CoV-2 activity, showing half maximal effective concentrations (EC50) of 0.47 and 1.22 μg/mL, respectively. Molecular docking simulation suggested IVS320 ability to interact with the SARS-CoV-2 viral protein. Finally, the highest antichagasic activity, expressed as percentage of Tripanosoma cruzi growth inhibition, was observed with IVS320-βCD/KN (70%) and IVS320-MβCD/PM (72%), while IVS320 alone exhibited only approximately 48% inhibition at the highest concentration (100 μg/mL).Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNOliveira, Verônica da SilvaSilva, Cláudia Cândidade Freitas Oliveira, Johny Wysllasda Silva, Marcelo de SousaFerreira, Patricia Garciada Siva, Fernando de CarvalhoFerreira, Vitor FranciscoBarbosa, Euzébio GuimarãesBarbosa, Cecília GomesMoraes, Carolina BorsoiFreitas-Junior, Lucio Holanda Gondim deConverti, AttilioLima, Ádley Antonini Neves de2023-07-07T22:14:39Z2023-032023-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/154978eng1773-2247PURE: 64265088https://doi.org/10.1016/j.jddst.2023.104229info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:29Zoai:run.unl.pt:10362/154978Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:52.743511Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| title |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| spellingShingle |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone Oliveira, Verônica da Silva Anti-SARS-CoV-2 Antichagasic activity Inclusion complexes Naphthoquinone RM Therapeutics. Pharmacology QR355 Virology QR Microbiology RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Pharmaceutical Science Biochemistry, Genetics and Molecular Biology (miscellaneous) Parasitology Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| title_short |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| title_full |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| title_fullStr |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| title_full_unstemmed |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| title_sort |
The evaluation of in vitro antichagasic and anti-SARS-CoV-2 potential of inclusion complexes of β- and methyl-β-cyclodextrin with naphthoquinone |
| author |
Oliveira, Verônica da Silva |
| author_facet |
Oliveira, Verônica da Silva Silva, Cláudia Cândida de Freitas Oliveira, Johny Wysllas da Silva, Marcelo de Sousa Ferreira, Patricia Garcia da Siva, Fernando de Carvalho Ferreira, Vitor Francisco Barbosa, Euzébio Guimarães Barbosa, Cecília Gomes Moraes, Carolina Borsoi Freitas-Junior, Lucio Holanda Gondim de Converti, Attilio Lima, Ádley Antonini Neves de |
| author_role |
author |
| author2 |
Silva, Cláudia Cândida de Freitas Oliveira, Johny Wysllas da Silva, Marcelo de Sousa Ferreira, Patricia Garcia da Siva, Fernando de Carvalho Ferreira, Vitor Francisco Barbosa, Euzébio Guimarães Barbosa, Cecília Gomes Moraes, Carolina Borsoi Freitas-Junior, Lucio Holanda Gondim de Converti, Attilio Lima, Ádley Antonini Neves de |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) RUN |
| dc.contributor.author.fl_str_mv |
Oliveira, Verônica da Silva Silva, Cláudia Cândida de Freitas Oliveira, Johny Wysllas da Silva, Marcelo de Sousa Ferreira, Patricia Garcia da Siva, Fernando de Carvalho Ferreira, Vitor Francisco Barbosa, Euzébio Guimarães Barbosa, Cecília Gomes Moraes, Carolina Borsoi Freitas-Junior, Lucio Holanda Gondim de Converti, Attilio Lima, Ádley Antonini Neves de |
| dc.subject.por.fl_str_mv |
Anti-SARS-CoV-2 Antichagasic activity Inclusion complexes Naphthoquinone RM Therapeutics. Pharmacology QR355 Virology QR Microbiology RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Pharmaceutical Science Biochemistry, Genetics and Molecular Biology (miscellaneous) Parasitology Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| topic |
Anti-SARS-CoV-2 Antichagasic activity Inclusion complexes Naphthoquinone RM Therapeutics. Pharmacology QR355 Virology QR Microbiology RA Public aspects of medicine RA0421 Public health. Hygiene. Preventive Medicine Infectious Diseases Pharmaceutical Science Biochemistry, Genetics and Molecular Biology (miscellaneous) Parasitology Virology SDG 3 - Good Health and Well-being SDG 9 - Industry, Innovation, and Infrastructure |
| description |
Funding Information: The authors thank the Coordination for the Improvement of Higher Education Personnel (CAPES) and the National Council for Scientific and Technological Development (CNPq) for their financial support. This study was supported by the CAPES — number 88887.505029/2020–00 . Cecilia Gomes Barbosa receives a scholarship funded by CAPES — number 88887.643352/2021–00 . Publisher Copyright: © 2023 Elsevier B.V. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07-07T22:14:39Z 2023-03 2023-03-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/154978 |
| url |
http://hdl.handle.net/10362/154978 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1773-2247 PURE: 64265088 https://doi.org/10.1016/j.jddst.2023.104229 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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12 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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