In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity

Detalhes bibliográficos
Autor(a) principal: Falcão, Soraia
Data de Publicação: 2014
Outros Autores: Vale, Nuno, Cos, Paul, Gomes, Paula, Freire, Cristina, Maes, Louis, Vilas-Boas, Miguel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/16227
Resumo: Propolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC-5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study.
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spelling In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activityAntimicrobial activityAntioxidant activityAntiprotozoal activityPhenolic compoundsPropolisPropolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC-5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study.Soraia I. Falcão thanks FCT for the PhD grant SFRH/BD/44855/2008. N. Vale thanks FCT for the Post-Doc grant SFRH/BPD/48345/2008. Thanks also to FCT for financial support provided to CIMO (PEst-OE/ AGR/UI0690/2011) and CIQ-UP (PEst-C/QUI/UI0081/2011). Thanks are due to the National Federation of Portuguese Beekeepers, for supplying propolis samples.Biblioteca Digital do IPBFalcão, SoraiaVale, NunoCos, PaulGomes, PaulaFreire, CristinaMaes, LouisVilas-Boas, Miguel2018-01-19T10:00:00Z20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/16227engFalcão, Soraia I.; Vale, Nuno; Cos, Paul; Gomes, Paula; Freire, Cristina; Maes, Louis; Vilas-Boas, Miguel (2014). In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity. Phytotherapy Research. ISSN 0951-418X. 28, p. 437-4430951-418X10.1002/ptr.5013info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:37:20Zoai:bibliotecadigital.ipb.pt:10198/16227Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:05:27.895330Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
title In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
spellingShingle In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
Falcão, Soraia
Antimicrobial activity
Antioxidant activity
Antiprotozoal activity
Phenolic compounds
Propolis
title_short In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
title_full In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
title_fullStr In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
title_full_unstemmed In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
title_sort In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity
author Falcão, Soraia
author_facet Falcão, Soraia
Vale, Nuno
Cos, Paul
Gomes, Paula
Freire, Cristina
Maes, Louis
Vilas-Boas, Miguel
author_role author
author2 Vale, Nuno
Cos, Paul
Gomes, Paula
Freire, Cristina
Maes, Louis
Vilas-Boas, Miguel
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Falcão, Soraia
Vale, Nuno
Cos, Paul
Gomes, Paula
Freire, Cristina
Maes, Louis
Vilas-Boas, Miguel
dc.subject.por.fl_str_mv Antimicrobial activity
Antioxidant activity
Antiprotozoal activity
Phenolic compounds
Propolis
topic Antimicrobial activity
Antioxidant activity
Antiprotozoal activity
Phenolic compounds
Propolis
description Propolis is a beehive product with a very complex chemical composition, used since ancient times in several therapeutic treatments. As a contribution to the improvement of drugs against several tropical diseases caused by protozoa, we screened Portuguese propolis and its potential floral sources Populus x Canadensis and Cistus ladanifer against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei and Trypanosoma cruzi. The toxicity against MRC-5 fibroblast cells was evaluated to assess selectivity. The in vitro assays were performed following the recommendations of WHO Special Programme for Research and Training in Tropical Diseases (TDR) and revealed moderate activity, with the propolis extracts presenting the relatively highest inhibitory effect against T. brucei. Additionally, the antimicrobial activity against Staphylococcus aureus, Candida albicans, Trichophyton rubrum and Aspergillus fumigatus was also verified with the better results observed against T. rubrum. The quality of the extracts was controlled by evaluating the phenolic content and antioxidant activity. The observed biological activity variations are associated with the variable chemical composition of the propolis and the potential floral sources under study.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
2018-01-19T10:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/16227
url http://hdl.handle.net/10198/16227
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Falcão, Soraia I.; Vale, Nuno; Cos, Paul; Gomes, Paula; Freire, Cristina; Maes, Louis; Vilas-Boas, Miguel (2014). In vitro evaluation of portuguese propolis and floral sources for antiprotozoal, antibacterial and antifungal activity. Phytotherapy Research. ISSN 0951-418X. 28, p. 437-443
0951-418X
10.1002/ptr.5013
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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