Physical-chemical properties of cross-linked chitosan electrospun fiber mats

Detalhes bibliográficos
Autor(a) principal: Sencadas, Vítor João Gomes Silva
Data de Publicação: 2012
Outros Autores: Correia, D. M., Ribeiro, C., Moreira, Susana Margarida Gomes, Botelho, Gabriela, Gómez Ribelles, J. L., Lanceros-Méndez, S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/23211
Resumo: Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61 % for the Protasan material down to 17 % for the cross-linking fiber mats. A swelling index up to 1000 % was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.
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spelling Physical-chemical properties of cross-linked chitosan electrospun fiber matsChitosan scaffoldsElectrospinningCrystallinityBiomaterialsNanofibersScience & TechnologyChitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61 % for the Protasan material down to 17 % for the cross-linking fiber mats. A swelling index up to 1000 % was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.This work is funded by FEDER funds through the "Programa Operacional Factores de Competitividade – COMPETE" and by national funds by FCT- Fundação para a Ciência e a Tecnologia, project references NANO/NMed-SD/0156/2007. V.S. and SM thanks the FCT grants SFRH/BPD/63148/2009 and SFRH/BPD/64726/2009, respectively. The authors also thank the support of the COST Action MP1003, 2010 ‘European Scientific Network for Artificial Muscles’ (ESNAM). JLGR acknowledge the support of the Spanish Ministry of Science and Innovation through project No. MAT2010-21611-C03-01 (including the FEDER financial support) and Programa Nacional de Internacionalización de la I+D project EUI2008-00126. The authors also thank the National NMR Network (National Program for Scientific Re-equipment, REDE/1517/RMN/2005, funds from POCI 2010 (FEDER) and FCT) and Microscopy Service of the UPV for the use of their lab.ElsevierUniversidade do MinhoSencadas, Vítor João Gomes SilvaCorreia, D. M.Ribeiro, C.Moreira, Susana Margarida GomesBotelho, GabrielaGómez Ribelles, J. L.Lanceros-Méndez, S.20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/23211eng0142-941810.1016/j.polymertesting.2012.07.010info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:07:08Zoai:repositorium.sdum.uminho.pt:1822/23211Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:58:00.407282Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Physical-chemical properties of cross-linked chitosan electrospun fiber mats
title Physical-chemical properties of cross-linked chitosan electrospun fiber mats
spellingShingle Physical-chemical properties of cross-linked chitosan electrospun fiber mats
Sencadas, Vítor João Gomes Silva
Chitosan scaffolds
Electrospinning
Crystallinity
Biomaterials
Nanofibers
Science & Technology
title_short Physical-chemical properties of cross-linked chitosan electrospun fiber mats
title_full Physical-chemical properties of cross-linked chitosan electrospun fiber mats
title_fullStr Physical-chemical properties of cross-linked chitosan electrospun fiber mats
title_full_unstemmed Physical-chemical properties of cross-linked chitosan electrospun fiber mats
title_sort Physical-chemical properties of cross-linked chitosan electrospun fiber mats
author Sencadas, Vítor João Gomes Silva
author_facet Sencadas, Vítor João Gomes Silva
Correia, D. M.
Ribeiro, C.
Moreira, Susana Margarida Gomes
Botelho, Gabriela
Gómez Ribelles, J. L.
Lanceros-Méndez, S.
author_role author
author2 Correia, D. M.
Ribeiro, C.
Moreira, Susana Margarida Gomes
Botelho, Gabriela
Gómez Ribelles, J. L.
Lanceros-Méndez, S.
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Sencadas, Vítor João Gomes Silva
Correia, D. M.
Ribeiro, C.
Moreira, Susana Margarida Gomes
Botelho, Gabriela
Gómez Ribelles, J. L.
Lanceros-Méndez, S.
dc.subject.por.fl_str_mv Chitosan scaffolds
Electrospinning
Crystallinity
Biomaterials
Nanofibers
Science & Technology
topic Chitosan scaffolds
Electrospinning
Crystallinity
Biomaterials
Nanofibers
Science & Technology
description Chitosan fiber mats were successfully processed by electrospinning. The as-spun fiber mats were neutralized with ethanol and cross-linked with glutaraldehyde. A decrease of the fiber average diameter from 243 ± 43 nm down to 215.53 nm was observed for the neutralized and cross-linking chitosan membrane. It was found that the processing conditions do not alter the initial deacetylation degree of the polymer. Polymer crystallinity index showed a decrease from 61 % for the Protasan material down to 17 % for the cross-linking fiber mats. A swelling index up to 1000 % was observed for the cross-linked samples. Preliminary MC-3T3-E1cell culture results showed good cell adhesion and proliferation in the cross-linked chitosan fiber mats.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/23211
url http://hdl.handle.net/1822/23211
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0142-9418
10.1016/j.polymertesting.2012.07.010
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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