Gap geometry dictates epithelial closure efficiency

• Autor(a) principal: Ravasio, Andrea
• Data de Publicação: 2015
• Outros Autores: Cheddadi, Ibrahim, Chen, Tianchi, Pereira, Telmo, Ong, Hui Ting, Bertocchi, Cristina, Brugues, Agusti, Jacinto, Antonio, Kabla, Alexandre J., Toyama, Yusuke, Trepat, Xavier, Gov, Nir, Neves De Almeida, Luís, Ladoux, Benoit
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: https://doi.org/10.1038/ncomms8683
• topic: COLLECTIVE CELL-MIGRATION; EXTRACELLULAR-MATRIX; DORSAL CLOSURE; WOUND REPAIR; DROSOPHILA EMBRYOS; DYNAMIC-ANALYSIS; GENE-EXPRESSION; STRESS FIBERS; LEADING-EDGE; SINGLE-CELL; Chemistry(all); Biochemistry, Genetics and Molecular Biology(all); Physics and Astronomy(all)

We thank group members from MBI Rene-Marc Mege and W.J. Nelson for helpful discussions. We also thank MBI Microfabrication (Gianluca Grenci and Mohammed Asraf), MBI Science Communication Core (Larisa Bulavina, Andrew Wong and Steven Wolf) and MBI Microscopy Core (Felix Margadant) for continuous support. We are grateful to S. Yonemura and W.J. Nelson for their generous gift of MDCK cell lines and to Michael W. Davidson and Pakorn Kanchanawong for mApple-paxillin plasmid. Financial supports from the Human Frontier Science Program (grant RGP0040/2012), the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant agreement no. 617233, Agence Nationale pour la Recherche project REGENR (grant ANR-11-BSV5-0021), Pessoa programme (project 30920XM) and the Mechanobiology Institute are gratefully acknowledged. XT acknowledges Spanish Ministry of Economy and Competitiveness (BFU2012-38146), the Generalitat de Catalunya (2014-SGR-927), and the European Research Council (CoG-616480). B.L. acknowledges the Institut Universitaire de France and T.C. the USPC-NUS agreement for his fellowship.