Sacubitril/valsartan: A practical guide

Detalhes bibliográficos
Autor(a) principal: Fonseca, Cândida
Data de Publicação: 2019
Outros Autores: Brito, Dulce, Ferreira, Jorge, Franco, Fátima, Morais, João, Silva Cardoso, José
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/149264
Resumo: Funding : Financial support for medical editorial assistance was provided by Novartis Farma --- Produtos Farmacêuticos S.A. The authors had full control of the content and made the final decision on all aspects of this article.
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spelling Sacubitril/valsartan: A practical guideHeart failure with reduced ejection fractionPARADIGM-HFPractical guidanceSacubitril/valsartanFunding : Financial support for medical editorial assistance was provided by Novartis Farma --- Produtos Farmacêuticos S.A. The authors had full control of the content and made the final decision on all aspects of this article.© 2019 Sociedade Portuguesa de Cardiologia Renin-angiotensin-aldosterone system (RAAS) inhibitors are a cornerstone in the treatment of heart failure with reduced ejection fraction (HFrEF). Sacubitril/valsartan modulates the neurohormonal axis by inhibiting both angiotensin receptors and neprilysin, and improves neurohormonal balance more than blocking the RAAS alone. The PARADIGM-HF trial validated this new treatment option for patients with HFrEF. Sacubitril/valsartan was also more effective than enalapril in slowing disease progression by decreasing the risk of worsening heart failure requiring hospitalization or emergency admission and the need for intensified therapy, heart failure devices or cardiac transplantation. More than 70% of patients included in PARADIGM-HF were in NYHA class II, and overall, the results indicate that sacubitril/valsartan should be started in the earliest symptomatic stages of the disease. As PARADIGM-HF has excellent robustness for a cardiovascular trial, sacubitril/valsartan has been included as a new treatment option with a strong level of recommendation in the main international guidelines. This expert task force proposes a practical guide to the use of this new drug that has been endorsed by the Working Group on Heart Failure of the Portuguese Society of Cardiology.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNFonseca, CândidaBrito, DulceFerreira, JorgeFranco, FátimaMorais, JoãoSilva Cardoso, José2023-02-15T22:14:54Z2019-052019-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/149264eng0870-2551PURE: 11387572https://doi.org/10.1016/j.repc.2018.10.008info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:31:10Zoai:run.unl.pt:10362/149264Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:40.955120Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Sacubitril/valsartan: A practical guide
title Sacubitril/valsartan: A practical guide
spellingShingle Sacubitril/valsartan: A practical guide
Fonseca, Cândida
Heart failure with reduced ejection fraction
PARADIGM-HF
Practical guidance
Sacubitril/valsartan
title_short Sacubitril/valsartan: A practical guide
title_full Sacubitril/valsartan: A practical guide
title_fullStr Sacubitril/valsartan: A practical guide
title_full_unstemmed Sacubitril/valsartan: A practical guide
title_sort Sacubitril/valsartan: A practical guide
author Fonseca, Cândida
author_facet Fonseca, Cândida
Brito, Dulce
Ferreira, Jorge
Franco, Fátima
Morais, João
Silva Cardoso, José
author_role author
author2 Brito, Dulce
Ferreira, Jorge
Franco, Fátima
Morais, João
Silva Cardoso, José
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Fonseca, Cândida
Brito, Dulce
Ferreira, Jorge
Franco, Fátima
Morais, João
Silva Cardoso, José
dc.subject.por.fl_str_mv Heart failure with reduced ejection fraction
PARADIGM-HF
Practical guidance
Sacubitril/valsartan
topic Heart failure with reduced ejection fraction
PARADIGM-HF
Practical guidance
Sacubitril/valsartan
description Funding : Financial support for medical editorial assistance was provided by Novartis Farma --- Produtos Farmacêuticos S.A. The authors had full control of the content and made the final decision on all aspects of this article.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
2019-05-01T00:00:00Z
2023-02-15T22:14:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/149264
url http://hdl.handle.net/10362/149264
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0870-2551
PURE: 11387572
https://doi.org/10.1016/j.repc.2018.10.008
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
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instacron:RCAAP
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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