Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/122441 |
Resumo: | Publisher Copyright: © 2021 Grau-Bové et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locusEcology, Evolution, Behavior and SystematicsMolecular BiologyGeneticsGenetics(clinical)Cancer ResearchSDG 3 - Good Health and Well-beingSDG 15 - Life on LandPublisher Copyright: © 2021 Grau-Bové et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Vector population control using insecticides is a key element of current strategies to prevent malaria transmission in Africa. The introduction of effective insecticides, such as the organophosphate pirimiphos-methyl, is essential to overcome the recurrent emergence of resistance driven by the highly diverse Anopheles genomes. Here, we use a population genomic approach to investigate the basis of pirimiphos-methyl resistance in the major malaria vectors Anopheles gambiae and A. coluzzii. A combination of copy number variation and a single non-synonymous substitution in the acetylcholinesterase gene, Ace1, provides the key resistance diagnostic in an A. coluzzii population from Côte d’Ivoire that we used for sequence-based association mapping, with replication in other West African populations. The Ace1 substitution and duplications occur on a unique resistance haplotype that evolved in A. gambiae and introgressed into A. coluzzii, and is now common in West Africa primarily due to selection imposed by other organophosphate or carbamate insecticides. Our findings highlight the predictive value of this complex resistance haplotype for phenotypic resistance and clarify its evolutionary history, providing tools to for molecular surveillance of the current and future effectiveness of pirimiphos-methyl based interventions.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)Vector borne diseases and pathogens (VBD)RUNAnopheles gambiae 1000 Genomes ConsortiumGrau-Bové, XavierLucas, EricPipini, DimitraRippon, Emilyvan ‘t Hof, Arjèn E.Constant, EdiDadzie, SamuelEgyir-Yawson, AlexanderEssandoh, JohnChabi, JosephDjogbénou, LucHarding, Nicholas J.Miles, AlistairKwiatkowski, Dominic P.Donnelly, Martin J.Weetman, DavidAmaya-Romero, Jorge EdouardoAyala, DiegoBattey, C. J.Bejon, PhilipBesansky, Nora J.Burt, AustinCano, JorgeCaputo, BeniaminoConstant, EdiCostantini, CarloCoulibaly, Boubacardella Torre, AlessandraDiabaté, AbdoulayeDinis, JoãoDonnelly, Martin J.Drury, EleanorEdouardo, JorgeElissa, NohalEssandoh, JohnFontaine, Michael C.Godfray, Charles H.J.Hahn, Matthew W.Harding, Nicholas J.Henrichs, ChristaHubbart, ChristinaIsaacs, Alison T.Jawara, MusaJeffreys, Anna E.Jyothi, DushyanthKamali, MaryamKern, Andrew D.Kwiatkowski, Dominic P.Clarkson, Chris S.Pinto, João2021-08-12T23:20:43Z2021-01-212021-01-21T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/122441eng1553-7390PURE: 33164832https://doi.org/10.1371/journal.pgen.1009253info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:04:08Zoai:run.unl.pt:10362/122441Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:44:47.526329Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| title |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| spellingShingle |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus Anopheles gambiae 1000 Genomes Consortium Ecology, Evolution, Behavior and Systematics Molecular Biology Genetics Genetics(clinical) Cancer Research SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| title_short |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| title_full |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| title_fullStr |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| title_full_unstemmed |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| title_sort |
Resistance to pirimiphos-methyl in West African Anopheles is spreading via duplication and introgression of the Ace1 locus |
| author |
Anopheles gambiae 1000 Genomes Consortium |
| author_facet |
Anopheles gambiae 1000 Genomes Consortium Grau-Bové, Xavier Lucas, Eric Pipini, Dimitra Rippon, Emily van ‘t Hof, Arjèn E. Constant, Edi Dadzie, Samuel Egyir-Yawson, Alexander Essandoh, John Chabi, Joseph Djogbénou, Luc Harding, Nicholas J. Miles, Alistair Kwiatkowski, Dominic P. Donnelly, Martin J. Weetman, David Amaya-Romero, Jorge Edouardo Ayala, Diego Battey, C. J. Bejon, Philip Besansky, Nora J. Burt, Austin Cano, Jorge Caputo, Beniamino Costantini, Carlo Coulibaly, Boubacar della Torre, Alessandra Diabaté, Abdoulaye Dinis, João Drury, Eleanor Edouardo, Jorge Elissa, Nohal Fontaine, Michael C. Godfray, Charles H.J. Hahn, Matthew W. Henrichs, Christa Hubbart, Christina Isaacs, Alison T. Jawara, Musa Jeffreys, Anna E. Jyothi, Dushyanth Kamali, Maryam Kern, Andrew D. Clarkson, Chris S. Pinto, João |
| author_role |
author |
| author2 |
Grau-Bové, Xavier Lucas, Eric Pipini, Dimitra Rippon, Emily van ‘t Hof, Arjèn E. Constant, Edi Dadzie, Samuel Egyir-Yawson, Alexander Essandoh, John Chabi, Joseph Djogbénou, Luc Harding, Nicholas J. Miles, Alistair Kwiatkowski, Dominic P. Donnelly, Martin J. Weetman, David Amaya-Romero, Jorge Edouardo Ayala, Diego Battey, C. J. Bejon, Philip Besansky, Nora J. Burt, Austin Cano, Jorge Caputo, Beniamino Costantini, Carlo Coulibaly, Boubacar della Torre, Alessandra Diabaté, Abdoulaye Dinis, João Drury, Eleanor Edouardo, Jorge Elissa, Nohal Fontaine, Michael C. Godfray, Charles H.J. Hahn, Matthew W. Henrichs, Christa Hubbart, Christina Isaacs, Alison T. Jawara, Musa Jeffreys, Anna E. Jyothi, Dushyanth Kamali, Maryam Kern, Andrew D. Clarkson, Chris S. Pinto, João |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Instituto de Higiene e Medicina Tropical (IHMT) Global Health and Tropical Medicine (GHTM) Vector borne diseases and pathogens (VBD) RUN |
| dc.contributor.author.fl_str_mv |
Anopheles gambiae 1000 Genomes Consortium Grau-Bové, Xavier Lucas, Eric Pipini, Dimitra Rippon, Emily van ‘t Hof, Arjèn E. Constant, Edi Dadzie, Samuel Egyir-Yawson, Alexander Essandoh, John Chabi, Joseph Djogbénou, Luc Harding, Nicholas J. Miles, Alistair Kwiatkowski, Dominic P. Donnelly, Martin J. Weetman, David Amaya-Romero, Jorge Edouardo Ayala, Diego Battey, C. J. Bejon, Philip Besansky, Nora J. Burt, Austin Cano, Jorge Caputo, Beniamino Constant, Edi Costantini, Carlo Coulibaly, Boubacar della Torre, Alessandra Diabaté, Abdoulaye Dinis, João Donnelly, Martin J. Drury, Eleanor Edouardo, Jorge Elissa, Nohal Essandoh, John Fontaine, Michael C. Godfray, Charles H.J. Hahn, Matthew W. Harding, Nicholas J. Henrichs, Christa Hubbart, Christina Isaacs, Alison T. Jawara, Musa Jeffreys, Anna E. Jyothi, Dushyanth Kamali, Maryam Kern, Andrew D. Kwiatkowski, Dominic P. Clarkson, Chris S. Pinto, João |
| dc.subject.por.fl_str_mv |
Ecology, Evolution, Behavior and Systematics Molecular Biology Genetics Genetics(clinical) Cancer Research SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| topic |
Ecology, Evolution, Behavior and Systematics Molecular Biology Genetics Genetics(clinical) Cancer Research SDG 3 - Good Health and Well-being SDG 15 - Life on Land |
| description |
Publisher Copyright: © 2021 Grau-Bové et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-08-12T23:20:43Z 2021-01-21 2021-01-21T00:00:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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http://hdl.handle.net/10362/122441 |
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http://hdl.handle.net/10362/122441 |
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eng |
| language |
eng |
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1553-7390 PURE: 33164832 https://doi.org/10.1371/journal.pgen.1009253 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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