Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/103809 https://doi.org/10.3390/cancers13153885 |
Resumo: | Soft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-associated neutrophils (TANs), and dendritic cells (DCs) were associated with a better outcome. On the contrary, tumor-associated macrophages (TAMs) were correlated with a poor outcome. The evaluation of peripheral blood immunological status in STS could also be important and is still underexplored. The increased lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR), higher levels of monocytic myeloid-derived suppressor cells (M-MDSCs), and Tim-3 positive CD8 T cells appear to be negative prognostic markers. Meanwhile, NKG2D-positive CD8 T cells were correlated with a better outcome. Some soluble factors, such as cytokines, chemokines, growth factors, and immune checkpoints were associated with the prognosis. Similarly, the expression of immune-related genes in STS was also reviewed. Despite these efforts, only very little is known, and much research is still needed to clarify the role of the immune system in STS. |
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Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapysoft tissue sarcomaimmune monitoringimmunophenotypingcytokinesimmune checkpointsgene expressionSoft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-associated neutrophils (TANs), and dendritic cells (DCs) were associated with a better outcome. On the contrary, tumor-associated macrophages (TAMs) were correlated with a poor outcome. The evaluation of peripheral blood immunological status in STS could also be important and is still underexplored. The increased lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR), higher levels of monocytic myeloid-derived suppressor cells (M-MDSCs), and Tim-3 positive CD8 T cells appear to be negative prognostic markers. Meanwhile, NKG2D-positive CD8 T cells were correlated with a better outcome. Some soluble factors, such as cytokines, chemokines, growth factors, and immune checkpoints were associated with the prognosis. Similarly, the expression of immune-related genes in STS was also reviewed. Despite these efforts, only very little is known, and much research is still needed to clarify the role of the immune system in STS.MDPI2021-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/103809http://hdl.handle.net/10316/103809https://doi.org/10.3390/cancers13153885eng2072-6694Sousa, Luana MadalenaAlmeida, Jani SofiaFortes-Andrade, TâniaSantos Rosa, ManuelTavares, PauloCasanova, José ManuelRodrigues-Santos, Pauloinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T21:39:10Zoai:estudogeral.uc.pt:10316/103809Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:20:34.944399Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
title |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
spellingShingle |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy Sousa, Luana Madalena soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression |
title_short |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
title_full |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
title_fullStr |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
title_full_unstemmed |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
title_sort |
Tumor and Peripheral Immune Status in Soft Tissue Sarcoma: Implications for Immunotherapy |
author |
Sousa, Luana Madalena |
author_facet |
Sousa, Luana Madalena Almeida, Jani Sofia Fortes-Andrade, Tânia Santos Rosa, Manuel Tavares, Paulo Casanova, José Manuel Rodrigues-Santos, Paulo |
author_role |
author |
author2 |
Almeida, Jani Sofia Fortes-Andrade, Tânia Santos Rosa, Manuel Tavares, Paulo Casanova, José Manuel Rodrigues-Santos, Paulo |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Sousa, Luana Madalena Almeida, Jani Sofia Fortes-Andrade, Tânia Santos Rosa, Manuel Tavares, Paulo Casanova, José Manuel Rodrigues-Santos, Paulo |
dc.subject.por.fl_str_mv |
soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression |
topic |
soft tissue sarcoma immune monitoring immunophenotyping cytokines immune checkpoints gene expression |
description |
Soft Tissue Sarcomas (STS) are a heterogeneous and rare group of tumors. Immune cells, soluble factors, and immune checkpoints are key elements of the complex tumor microenvironment. Monitoring these elements could be used to predict the outcome of the disease, the response to therapy, and lead to the development of new immunotherapeutic approaches. Tumor-infiltrating B cells, Natural Killer (NK) cells, tumor-associated neutrophils (TANs), and dendritic cells (DCs) were associated with a better outcome. On the contrary, tumor-associated macrophages (TAMs) were correlated with a poor outcome. The evaluation of peripheral blood immunological status in STS could also be important and is still underexplored. The increased lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio (NLR), higher levels of monocytic myeloid-derived suppressor cells (M-MDSCs), and Tim-3 positive CD8 T cells appear to be negative prognostic markers. Meanwhile, NKG2D-positive CD8 T cells were correlated with a better outcome. Some soluble factors, such as cytokines, chemokines, growth factors, and immune checkpoints were associated with the prognosis. Similarly, the expression of immune-related genes in STS was also reviewed. Despite these efforts, only very little is known, and much research is still needed to clarify the role of the immune system in STS. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-08-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/103809 http://hdl.handle.net/10316/103809 https://doi.org/10.3390/cancers13153885 |
url |
http://hdl.handle.net/10316/103809 https://doi.org/10.3390/cancers13153885 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2072-6694 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134097878024192 |