Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus

Detalhes bibliográficos
Autor(a) principal: Nikolopoulos, Dionysis
Data de Publicação: 2024
Outros Autores: Lourenço, Maria Helena, Depascale, Roberto, Triantafyllias, Konstantinos, Parodis, Ioannis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/172570
Resumo: Funding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s).
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spelling Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosusglucocorticoidslow disease activityremissionsystemic lupus erythematosustreat-to-targetRheumatologySDG 3 - Good Health and Well-beingFunding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s).Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterised by a wide range of symptoms and a risk for irreversible organ damage, leading to increased morbidity and mortality. To improve long-term outcomes, innovative therapeutic goals have been explored, including attainment and maintenance of remission or low disease activity, with minimal use of glucocorticoids. Other goals encompass early diagnosis, potent yet less toxic therapies, appropriate glucocorticoid tapering, and better quality of life for the patients. Implementing a treat-to-target (T2T) approach involves treatment adjustments to achieve predefined objectives. Evidence from other chronic diseases, like hypertension and diabetes, supports the success of target-based approaches. In rheumatic diseases, the multitude of clinical features adds complexity to T2T strategies, but in rheumatoid arthritis, T2T has yielded improved outcomes. The application of T2T in SLE requires realistic therapeutic goals and practical tools for their measurement. International task forces have developed T2T recommendations for SLE, focusing on limiting disease activity, preventing organ damage, and minimising glucocorticoid use, while considering patients’ quality of life. Advancements in defining clinically meaningful remission and low disease activity states, coupled with promising novel therapies, have spurred progress in the management of SLE.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNNikolopoulos, DionysisLourenço, Maria HelenaDepascale, RobertoTriantafyllias, KonstantinosParodis, Ioannis2024-09-27T22:22:52Z2024-06-302024-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/172570eng2459-3516PURE: 99598594https://doi.org/10.31138/MJR.290424.ECIinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-07T01:38:02Zoai:run.unl.pt:10362/172570Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-07T01:38:02Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
title Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
spellingShingle Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
Nikolopoulos, Dionysis
glucocorticoids
low disease activity
remission
systemic lupus erythematosus
treat-to-target
Rheumatology
SDG 3 - Good Health and Well-being
title_short Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
title_full Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
title_fullStr Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
title_full_unstemmed Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
title_sort Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
author Nikolopoulos, Dionysis
author_facet Nikolopoulos, Dionysis
Lourenço, Maria Helena
Depascale, Roberto
Triantafyllias, Konstantinos
Parodis, Ioannis
author_role author
author2 Lourenço, Maria Helena
Depascale, Roberto
Triantafyllias, Konstantinos
Parodis, Ioannis
author2_role author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Nikolopoulos, Dionysis
Lourenço, Maria Helena
Depascale, Roberto
Triantafyllias, Konstantinos
Parodis, Ioannis
dc.subject.por.fl_str_mv glucocorticoids
low disease activity
remission
systemic lupus erythematosus
treat-to-target
Rheumatology
SDG 3 - Good Health and Well-being
topic glucocorticoids
low disease activity
remission
systemic lupus erythematosus
treat-to-target
Rheumatology
SDG 3 - Good Health and Well-being
description Funding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s).
publishDate 2024
dc.date.none.fl_str_mv 2024-09-27T22:22:52Z
2024-06-30
2024-06-30T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/172570
url http://hdl.handle.net/10362/172570
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2459-3516
PURE: 99598594
https://doi.org/10.31138/MJR.290424.ECI
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eu_rights_str_mv openAccess
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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