Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus
Autor(a) principal: | |
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Data de Publicação: | 2024 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/172570 |
Resumo: | Funding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s). |
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Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosusglucocorticoidslow disease activityremissionsystemic lupus erythematosustreat-to-targetRheumatologySDG 3 - Good Health and Well-beingFunding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s).Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that is characterised by a wide range of symptoms and a risk for irreversible organ damage, leading to increased morbidity and mortality. To improve long-term outcomes, innovative therapeutic goals have been explored, including attainment and maintenance of remission or low disease activity, with minimal use of glucocorticoids. Other goals encompass early diagnosis, potent yet less toxic therapies, appropriate glucocorticoid tapering, and better quality of life for the patients. Implementing a treat-to-target (T2T) approach involves treatment adjustments to achieve predefined objectives. Evidence from other chronic diseases, like hypertension and diabetes, supports the success of target-based approaches. In rheumatic diseases, the multitude of clinical features adds complexity to T2T strategies, but in rheumatoid arthritis, T2T has yielded improved outcomes. The application of T2T in SLE requires realistic therapeutic goals and practical tools for their measurement. International task forces have developed T2T recommendations for SLE, focusing on limiting disease activity, preventing organ damage, and minimising glucocorticoid use, while considering patients’ quality of life. Advancements in defining clinically meaningful remission and low disease activity states, coupled with promising novel therapies, have spurred progress in the management of SLE.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNNikolopoulos, DionysisLourenço, Maria HelenaDepascale, RobertoTriantafyllias, KonstantinosParodis, Ioannis2024-09-27T22:22:52Z2024-06-302024-06-30T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article14application/pdfhttp://hdl.handle.net/10362/172570eng2459-3516PURE: 99598594https://doi.org/10.31138/MJR.290424.ECIinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-10-07T01:38:02Zoai:run.unl.pt:10362/172570Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-10-07T01:38:02Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
title |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
spellingShingle |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus Nikolopoulos, Dionysis glucocorticoids low disease activity remission systemic lupus erythematosus treat-to-target Rheumatology SDG 3 - Good Health and Well-being |
title_short |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
title_full |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
title_fullStr |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
title_full_unstemmed |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
title_sort |
Evolving Concepts in Treat-to-Target Strategies for Systemic Lupus Erythematosus |
author |
Nikolopoulos, Dionysis |
author_facet |
Nikolopoulos, Dionysis Lourenço, Maria Helena Depascale, Roberto Triantafyllias, Konstantinos Parodis, Ioannis |
author_role |
author |
author2 |
Lourenço, Maria Helena Depascale, Roberto Triantafyllias, Konstantinos Parodis, Ioannis |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) Comprehensive Health Research Centre (CHRC) - pólo NMS RUN |
dc.contributor.author.fl_str_mv |
Nikolopoulos, Dionysis Lourenço, Maria Helena Depascale, Roberto Triantafyllias, Konstantinos Parodis, Ioannis |
dc.subject.por.fl_str_mv |
glucocorticoids low disease activity remission systemic lupus erythematosus treat-to-target Rheumatology SDG 3 - Good Health and Well-being |
topic |
glucocorticoids low disease activity remission systemic lupus erythematosus treat-to-target Rheumatology SDG 3 - Good Health and Well-being |
description |
Funding Information: IP has received grants from the Swedish Rheumatism Association (R-969696), King Gustaf V\u2019s 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckelfonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet. DN has received grants from Ulla o Roland Gustafssons Donationsfond (2024-49), Ulla och Gustaf af Ugglas stiftelse (2023-025029) and Reumatikerf\u00F6rbundet (2024 R-995557). Publisher Copyright: © 2024 The Author(s). |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-09-27T22:22:52Z 2024-06-30 2024-06-30T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/172570 |
url |
http://hdl.handle.net/10362/172570 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2459-3516 PURE: 99598594 https://doi.org/10.31138/MJR.290424.ECI |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
14 application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
mluisa.alvim@gmail.com |
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1817548554103685120 |