Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir

Detalhes bibliográficos
Autor(a) principal: Caria, João
Data de Publicação: 2023
Outros Autores: Vara-Luiz, Francisco, Maia, Inês, Joosten, Anneke, Val-Flores, Luís, Pinheiro, Hélder, Póvoas, Diana, Germano, Nuno, Maltez, Fernando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/155690
Resumo: Funding Information: The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant number UIDB/04295/2020 and UIDP/04295/2020. Publisher Copyright: © 2023 by the authors.
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spelling Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous CidofovirAIDScidofovirenteropathyfatalHIVmpoxprogressivetecovirimatInfectious DiseasesSDG 3 - Good Health and Well-beingFunding Information: The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant number UIDB/04295/2020 and UIDP/04295/2020. Publisher Copyright: © 2023 by the authors.We report a fatal case of disseminated mpox infection that progressed over more than three months in an HIV-infected patient with acquired immunodeficiency syndrome (AIDS). Mucocutaneous, pleuropulmonary, central nervous system, and gastrointestinal involvement was documented. This course of disease resembles progressive vaccinia, a formerly reported disease caused by uncontrolled replication of smallpox vaccination orthopoxviruses in immunosuppressed patients. Severe small bowel involvement jeopardized normal oral tecovirimat and antiretroviral therapy absorption. This problem prompted the use of full parenteral antiretrovirals and endovenous cidofovir. Although a remarkable decrease in HIV viral load occurred in six days, mpox infection continued to progress, and the patient died of septic shock. This case offers new clinical insights on the presentation of severe disease in AIDS patients. Moreover, this case alerts for the need for prompt therapy initiation in patients at risk of ominous clinical progression.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNCaria, JoãoVara-Luiz, FranciscoMaia, InêsJoosten, AnnekeVal-Flores, LuísPinheiro, HélderPóvoas, DianaGermano, NunoMaltez, Fernando2023-07-21T22:21:37Z2023-042023-04-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article9application/pdfhttp://hdl.handle.net/10362/155690eng2036-7449PURE: 66906098https://doi.org/10.3390/idr15020018info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:38:20Zoai:run.unl.pt:10362/155690Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:11.777395Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
title Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
spellingShingle Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
Caria, João
AIDS
cidofovir
enteropathy
fatal
HIV
mpox
progressive
tecovirimat
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
title_full Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
title_fullStr Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
title_full_unstemmed Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
title_sort Fatal Case of Progressive Mpox in a Patient with AIDS—Viral Enteropathy and Malabsorption Demanding the Use of Full Parenteral ARV and Endovenous Cidofovir
author Caria, João
author_facet Caria, João
Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
author_role author
author2 Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Caria, João
Vara-Luiz, Francisco
Maia, Inês
Joosten, Anneke
Val-Flores, Luís
Pinheiro, Hélder
Póvoas, Diana
Germano, Nuno
Maltez, Fernando
dc.subject.por.fl_str_mv AIDS
cidofovir
enteropathy
fatal
HIV
mpox
progressive
tecovirimat
Infectious Diseases
SDG 3 - Good Health and Well-being
topic AIDS
cidofovir
enteropathy
fatal
HIV
mpox
progressive
tecovirimat
Infectious Diseases
SDG 3 - Good Health and Well-being
description Funding Information: The writing of this manuscript received the support of Fundação para a Ciência e a Tecnologia, grant number UIDB/04295/2020 and UIDP/04295/2020. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-21T22:21:37Z
2023-04
2023-04-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/155690
url http://hdl.handle.net/10362/155690
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2036-7449
PURE: 66906098
https://doi.org/10.3390/idr15020018
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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