Anti-inflammatory potential of mushroom extracts and isolated metabolites
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/13350 |
Resumo: | Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators. |
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Anti-inflammatory potential of mushroom extracts and isolated metabolitesInflammationNSAIDsMushroomsBioactive compoundsBackground: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators.Biblioteca Digital do IPBTaofiq, OludemiMartins, AnabelaBarreiro, M.F.Ferreira, Isabel C.F.R.2016-10-03T08:39:12Z20162016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/10198/13350engTaofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016). Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology. ISSN 0924-2244. 50, p. 193-2100924-224410.1016/j.tifs.2016.02.005info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:31:12Zoai:bibliotecadigital.ipb.pt:10198/13350Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:03:26.429453Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
title |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
spellingShingle |
Anti-inflammatory potential of mushroom extracts and isolated metabolites Taofiq, Oludemi Inflammation NSAIDs Mushrooms Bioactive compounds |
title_short |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
title_full |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
title_fullStr |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
title_full_unstemmed |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
title_sort |
Anti-inflammatory potential of mushroom extracts and isolated metabolites |
author |
Taofiq, Oludemi |
author_facet |
Taofiq, Oludemi Martins, Anabela Barreiro, M.F. Ferreira, Isabel C.F.R. |
author_role |
author |
author2 |
Martins, Anabela Barreiro, M.F. Ferreira, Isabel C.F.R. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Taofiq, Oludemi Martins, Anabela Barreiro, M.F. Ferreira, Isabel C.F.R. |
dc.subject.por.fl_str_mv |
Inflammation NSAIDs Mushrooms Bioactive compounds |
topic |
Inflammation NSAIDs Mushrooms Bioactive compounds |
description |
Background: In the recent years natural resources are being in focus due to their great potential to be exploited in the discovery/development of novel bioactive compounds and, among them, mushrooms can be highlighted as alternative sources of anti-inflammatory agents. Scope and approach: The present review reports the anti-inflammatory activity of mushroom extracts and of their bioactive metabolites involved in this bioactive action. Additionally the most common assays used to evaluate mushrooms anti-inflammatory activity were also reviewed, including in vitro studies in cell lines, as well as in animal models in vivo. Key findings and conclusions: The anti-inflammatory compounds identified in mushrooms include polysaccharides, terpenes, phenolic acids, steroids, fatty acids and other metabolites. Among them, polysaccharides, terpenoids and phenolic compounds seem to be the most important contributors to the anti-inflammatory activity of mushrooms as demonstrated by numerous studies. However, clinical trials need to be conducted in order to confirm the effectiveness of some of these mushroom compounds namely, inhibitors of NF-κB pathway and of cyclooxygenase related with the expression of many inflammatory mediators. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-03T08:39:12Z 2016 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/13350 |
url |
http://hdl.handle.net/10198/13350 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Taofiq, Oludemi; Martins, Anabela; Barreiro, M.F.; Ferreira, Isabel C.F.R. (2016). Anti-inflammatory potential of mushroom extracts and isolated metabolites. Trends in Food Science & Technology. ISSN 0924-2244. 50, p. 193-210 0924-2244 10.1016/j.tifs.2016.02.005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135277636124672 |