Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
Autor(a) principal: | |
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Data de Publicação: | 2015 |
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Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/53206 |
Resumo: | © 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
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Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria speciesMafBNeisseriaImmunity geneToxin© 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.In addition to harmless commensal species, Neisseria genus encompasses two pathogenic species, N. meningitidis (the meningococcus) and N. gonorrhoeae (the gonococcus), which are responsible for meningitis and genital tract infections, respectively. Since the publication of the first Neisseria genome in 2000, the presence of several genomic islands (GI) comprising maf genes has been intriguing. These GIs account for approximately 2% of the genome of the pathogenic Neisseria species and the function of the proteins encoded by maf genes remained unknown. We showed that maf genes encode a functional toxin-immunity system where MafB is a toxin neutralized by an immunity protein named MafI. A strain can harbor several MafB/MafI modules with distinct toxic activities. MafB toxins are polymorphic toxins with a conserved N-terminal region and a variable C-terminal region. MafB N-terminal regions consist of a signal peptide and a domain named DUF1020 that is only found in the genus Neisseria. MafB C-terminal regions are highly polymorphic and encode toxic activities. We evidenced the presence of MafB in the culture supernatant of meningococcal cells and we observed a competitive advantage for a strain overexpressing a MafB toxin. Therefore, we characterized a highly variable family of toxin-immunity modules found in multiple loci in pathogenic Neisseria species.Shared Science Publishers OGRepositório da Universidade de LisboaJamet, AnneNassif, Xavier2022-05-27T15:13:20Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53206engMicrob Cell. 2015 Mar 2;2(3):88-9010.15698/mic2015.03.1942311-2638info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:53Zoai:repositorio.ul.pt:10451/53206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:10.075160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
title |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
spellingShingle |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species Jamet, Anne MafB Neisseria Immunity gene Toxin |
title_short |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
title_full |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
title_fullStr |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
title_full_unstemmed |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
title_sort |
Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species |
author |
Jamet, Anne |
author_facet |
Jamet, Anne Nassif, Xavier |
author_role |
author |
author2 |
Nassif, Xavier |
author2_role |
author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Jamet, Anne Nassif, Xavier |
dc.subject.por.fl_str_mv |
MafB Neisseria Immunity gene Toxin |
topic |
MafB Neisseria Immunity gene Toxin |
description |
© 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2022-05-27T15:13:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/53206 |
url |
http://hdl.handle.net/10451/53206 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Microb Cell. 2015 Mar 2;2(3):88-90 10.15698/mic2015.03.194 2311-2638 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Shared Science Publishers OG |
publisher.none.fl_str_mv |
Shared Science Publishers OG |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134592220790784 |