Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species

Detalhes bibliográficos
Autor(a) principal: Jamet, Anne
Data de Publicação: 2015
Outros Autores: Nassif, Xavier
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/53206
Resumo: © 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
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spelling Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria speciesMafBNeisseriaImmunity geneToxin© 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.In addition to harmless commensal species, Neisseria genus encompasses two pathogenic species, N. meningitidis (the meningococcus) and N. gonorrhoeae (the gonococcus), which are responsible for meningitis and genital tract infections, respectively. Since the publication of the first Neisseria genome in 2000, the presence of several genomic islands (GI) comprising maf genes has been intriguing. These GIs account for approximately 2% of the genome of the pathogenic Neisseria species and the function of the proteins encoded by maf genes remained unknown. We showed that maf genes encode a functional toxin-immunity system where MafB is a toxin neutralized by an immunity protein named MafI. A strain can harbor several MafB/MafI modules with distinct toxic activities. MafB toxins are polymorphic toxins with a conserved N-terminal region and a variable C-terminal region. MafB N-terminal regions consist of a signal peptide and a domain named DUF1020 that is only found in the genus Neisseria. MafB C-terminal regions are highly polymorphic and encode toxic activities. We evidenced the presence of MafB in the culture supernatant of meningococcal cells and we observed a competitive advantage for a strain overexpressing a MafB toxin. Therefore, we characterized a highly variable family of toxin-immunity modules found in multiple loci in pathogenic Neisseria species.Shared Science Publishers OGRepositório da Universidade de LisboaJamet, AnneNassif, Xavier2022-05-27T15:13:20Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/53206engMicrob Cell. 2015 Mar 2;2(3):88-9010.15698/mic2015.03.1942311-2638info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:58:53Zoai:repositorio.ul.pt:10451/53206Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:04:10.075160Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
title Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
spellingShingle Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
Jamet, Anne
MafB
Neisseria
Immunity gene
Toxin
title_short Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
title_full Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
title_fullStr Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
title_full_unstemmed Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
title_sort Characterization of the Maf family of polymorphic toxins in pathogenic Neisseria species
author Jamet, Anne
author_facet Jamet, Anne
Nassif, Xavier
author_role author
author2 Nassif, Xavier
author2_role author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Jamet, Anne
Nassif, Xavier
dc.subject.por.fl_str_mv MafB
Neisseria
Immunity gene
Toxin
topic MafB
Neisseria
Immunity gene
Toxin
description © 2015 Jamet and Nassif. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-01-01T00:00:00Z
2022-05-27T15:13:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/53206
url http://hdl.handle.net/10451/53206
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Microb Cell. 2015 Mar 2;2(3):88-90
10.15698/mic2015.03.194
2311-2638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Shared Science Publishers OG
publisher.none.fl_str_mv Shared Science Publishers OG
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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