Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.1/16669 |
Resumo: | Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further. |
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Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from TurkeyNepetaPolyphenolsAntioxidantEnzyme inhibitionPhytopharmaceuticsNepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.MDPISapientiaZengin, GokhanMahomoodally, Mohamad FawziAktumsek, AbdurrahmanJekő, JózsefCziáky, ZoltánRodrigues, Maria JoãoCustódio, LuísaPolat, RıdvanCakilcioglu, UgurAyna, AdnanGallo, MonicaMontesano, DomenicoPicot-Allain, Carene2021-06-28T09:25:03Z2021-06-092021-06-24T14:10:39Z2021-06-09T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/16669engPlants 10 (6): 1176 (2021)2223-774710.3390/plants10061176info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:28:38Zoai:sapientia.ualg.pt:10400.1/16669Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:06:45.631054Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
title |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
spellingShingle |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey Zengin, Gokhan Nepeta Polyphenols Antioxidant Enzyme inhibition Phytopharmaceutics |
title_short |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
title_full |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
title_fullStr |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
title_full_unstemmed |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
title_sort |
Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey |
author |
Zengin, Gokhan |
author_facet |
Zengin, Gokhan Mahomoodally, Mohamad Fawzi Aktumsek, Abdurrahman Jekő, József Cziáky, Zoltán Rodrigues, Maria João Custódio, Luísa Polat, Rıdvan Cakilcioglu, Ugur Ayna, Adnan Gallo, Monica Montesano, Domenico Picot-Allain, Carene |
author_role |
author |
author2 |
Mahomoodally, Mohamad Fawzi Aktumsek, Abdurrahman Jekő, József Cziáky, Zoltán Rodrigues, Maria João Custódio, Luísa Polat, Rıdvan Cakilcioglu, Ugur Ayna, Adnan Gallo, Monica Montesano, Domenico Picot-Allain, Carene |
author2_role |
author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Sapientia |
dc.contributor.author.fl_str_mv |
Zengin, Gokhan Mahomoodally, Mohamad Fawzi Aktumsek, Abdurrahman Jekő, József Cziáky, Zoltán Rodrigues, Maria João Custódio, Luísa Polat, Rıdvan Cakilcioglu, Ugur Ayna, Adnan Gallo, Monica Montesano, Domenico Picot-Allain, Carene |
dc.subject.por.fl_str_mv |
Nepeta Polyphenols Antioxidant Enzyme inhibition Phytopharmaceutics |
topic |
Nepeta Polyphenols Antioxidant Enzyme inhibition Phytopharmaceutics |
description |
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-28T09:25:03Z 2021-06-09 2021-06-24T14:10:39Z 2021-06-09T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.1/16669 |
url |
http://hdl.handle.net/10400.1/16669 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Plants 10 (6): 1176 (2021) 2223-7747 10.3390/plants10061176 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MDPI |
publisher.none.fl_str_mv |
MDPI |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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