The role of the gut microbiota in the subsistence of antibiotic resistance

Detalhes bibliográficos
Autor(a) principal: Leónidas Cardoso, Luís
Data de Publicação: 2020
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/98835
Resumo: "Antibiotic resistance is one of the major contemporary threats to global health. Studies on evolutionary biology, molecular biology and genetics have revealed that many phenomena contribute for the subsistence of resistant bacteria. The environment has been shown to be a key factor, capable of altering fitness costs and the epistasis patterns between resistance determinants. Still, few studies have ventured to assess the costs of antibiotic resistance in natural environments, and such studies are centered on pathogens. It is now known that commensal bacteria can act as reservoirs of resistance, and that resistant commensals can evolve to express pathogenicity and share resistance genes with pathogens. Here, we explore how selection acts on resistant, commensal E. coli in the mouse gut. (...)"
id RCAP_a9a0d097d1765a151003ce606658fae6
oai_identifier_str oai:run.unl.pt:10362/98835
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling The role of the gut microbiota in the subsistence of antibiotic resistancebacteriagutIntegrative Biology"Antibiotic resistance is one of the major contemporary threats to global health. Studies on evolutionary biology, molecular biology and genetics have revealed that many phenomena contribute for the subsistence of resistant bacteria. The environment has been shown to be a key factor, capable of altering fitness costs and the epistasis patterns between resistance determinants. Still, few studies have ventured to assess the costs of antibiotic resistance in natural environments, and such studies are centered on pathogens. It is now known that commensal bacteria can act as reservoirs of resistance, and that resistant commensals can evolve to express pathogenicity and share resistance genes with pathogens. Here, we explore how selection acts on resistant, commensal E. coli in the mouse gut. (...)"Gordo, IsabelRUNLeónidas Cardoso, Luís2020-06-04T14:16:18Z2020-03-062020-032020-03-06T00:00:00Zdoctoral thesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10362/98835enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:45:51Zoai:run.unl.pt:10362/98835Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:45:51Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The role of the gut microbiota in the subsistence of antibiotic resistance
title The role of the gut microbiota in the subsistence of antibiotic resistance
spellingShingle The role of the gut microbiota in the subsistence of antibiotic resistance
Leónidas Cardoso, Luís
bacteria
gut
Integrative Biology
title_short The role of the gut microbiota in the subsistence of antibiotic resistance
title_full The role of the gut microbiota in the subsistence of antibiotic resistance
title_fullStr The role of the gut microbiota in the subsistence of antibiotic resistance
title_full_unstemmed The role of the gut microbiota in the subsistence of antibiotic resistance
title_sort The role of the gut microbiota in the subsistence of antibiotic resistance
author Leónidas Cardoso, Luís
author_facet Leónidas Cardoso, Luís
author_role author
dc.contributor.none.fl_str_mv Gordo, Isabel
RUN
dc.contributor.author.fl_str_mv Leónidas Cardoso, Luís
dc.subject.por.fl_str_mv bacteria
gut
Integrative Biology
topic bacteria
gut
Integrative Biology
description "Antibiotic resistance is one of the major contemporary threats to global health. Studies on evolutionary biology, molecular biology and genetics have revealed that many phenomena contribute for the subsistence of resistant bacteria. The environment has been shown to be a key factor, capable of altering fitness costs and the epistasis patterns between resistance determinants. Still, few studies have ventured to assess the costs of antibiotic resistance in natural environments, and such studies are centered on pathogens. It is now known that commensal bacteria can act as reservoirs of resistance, and that resistant commensals can evolve to express pathogenicity and share resistance genes with pathogens. Here, we explore how selection acts on resistant, commensal E. coli in the mouse gut. (...)"
publishDate 2020
dc.date.none.fl_str_mv 2020-06-04T14:16:18Z
2020-03-06
2020-03
2020-03-06T00:00:00Z
dc.type.driver.fl_str_mv doctoral thesis
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/98835
url http://hdl.handle.net/10362/98835
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
_version_ 1817545744640376832

Registros relacionados