Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/37694 |
Resumo: | Copyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritisDietMediterranean dietGut microbiotaGut permeabilityRheumatoid arthritisCopyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Growing experimental and clinical evidence suggests that a chronic inflammatory response induced by gut dysbiosis can critically contribute to the development of rheumatic diseases, including rheumatoid arthritis (RA). Of interest, an adherence to a Mediterranean diet has been linked to a reduction in mortality and morbidity in patients with inflammatory diseases. Diet and intestinal microbiota are modifying factors that may influence intestinal barrier strength, functional integrity, and permeability regulation. Intestinal microbiota may play a crucial role in RA pathogenesis, but up to now no solid data has clarified a mechanistic relationship between gut microbiota and the development of RA. Nonetheless, microbiota composition in subjects with RA differs from that of controls and this altered microbiome can be partially restored after prescribing disease modifying antirheumatic drugs. High levels of Prevotella copri and similar species are correlated with low levels of microbiota previously associated with immune regulating properties. In addition, some nutrients can alter intestinal permeability and thereby influence the immune response without a known impact on the microbiota. However, critical questions remain to be elucidated, such as the way microbiome fluctuates in relation to diet, and how disease activity may be influenced by changes in diet, microbiota or diet-intestinal microbiota equilibrium.Frontiers MediaRepositório da Universidade de LisboaGuerreiro, Catarina SousaCalado, ÂngeloSousa, JoanaFonseca, João Eurico2019-03-26T14:13:35Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/37694engFront. Med. 5:3492296-858X10.3389/fmed.2018.00349info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:34:59Zoai:repositorio.ul.pt:10451/37694Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:51:42.311993Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
title |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
spellingShingle |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis Guerreiro, Catarina Sousa Diet Mediterranean diet Gut microbiota Gut permeability Rheumatoid arthritis |
title_short |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
title_full |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
title_fullStr |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
title_full_unstemmed |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
title_sort |
Diet, microbiota, and gut permeability : the unknown triad in rheumatoid arthritis |
author |
Guerreiro, Catarina Sousa |
author_facet |
Guerreiro, Catarina Sousa Calado, Ângelo Sousa, Joana Fonseca, João Eurico |
author_role |
author |
author2 |
Calado, Ângelo Sousa, Joana Fonseca, João Eurico |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Guerreiro, Catarina Sousa Calado, Ângelo Sousa, Joana Fonseca, João Eurico |
dc.subject.por.fl_str_mv |
Diet Mediterranean diet Gut microbiota Gut permeability Rheumatoid arthritis |
topic |
Diet Mediterranean diet Gut microbiota Gut permeability Rheumatoid arthritis |
description |
Copyright © 2018 Guerreiro, Calado, Sousa and Fonseca. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC-BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-03-26T14:13:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/37694 |
url |
http://hdl.handle.net/10451/37694 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Front. Med. 5:349 2296-858X 10.3389/fmed.2018.00349 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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