Prolactin and Autoimmunity
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/107610 https://doi.org/10.3389/fimmu.2018.00073 |
Resumo: | The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of the arguments that support this hypothesis. Certainly, motherhood represents one of the most remarkable challenges for the immune system, which not only has to allow for the conceptus, but also has to deal with complex endocrine alterations. Hormonal homeostasis is known to exert a crucial influence in achieving a competent and healthy immune system. Prolactin (PRL) has a bioactive function acting as a hormone and a cytokine. It interferes with immune system modulation, mainly inhibiting the negative selection of autoreactive B lymphocytes. Likewise, hyperprolactinemia has been described in relation to the pathogenesis and activity of several autoimmune disorders. Dopamine is an effective inhibitor of PRL secretion due to either a direct influence on the hypophysis or stimulation of postsynaptic dopamine receptors in the hypothalamus, arousing the release of the PRL inhibitory factor. Hence, dopamine agonists have proven to offer clinical benefits among autoimmune patients and represent a promising therapy to be explored. In this review, we attempt to provide a critical overview of the link between PRL, autoimmune diseases, and motherhood. |
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Prolactin and Autoimmunitysex hormonesprolactinautoimmunitysystemic lupus erythematosusmultiple sclerosissystemic sclerosisAnimalsAutoantibodiesAutoimmune DiseasesCytokinesFemaleGonadal Steroid HormonesHumansHyperprolactinemiaPregnancyProlactinSex FactorsAutoimmunityThe great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of the arguments that support this hypothesis. Certainly, motherhood represents one of the most remarkable challenges for the immune system, which not only has to allow for the conceptus, but also has to deal with complex endocrine alterations. Hormonal homeostasis is known to exert a crucial influence in achieving a competent and healthy immune system. Prolactin (PRL) has a bioactive function acting as a hormone and a cytokine. It interferes with immune system modulation, mainly inhibiting the negative selection of autoreactive B lymphocytes. Likewise, hyperprolactinemia has been described in relation to the pathogenesis and activity of several autoimmune disorders. Dopamine is an effective inhibitor of PRL secretion due to either a direct influence on the hypophysis or stimulation of postsynaptic dopamine receptors in the hypothalamus, arousing the release of the PRL inhibitory factor. Hence, dopamine agonists have proven to offer clinical benefits among autoimmune patients and represent a promising therapy to be explored. In this review, we attempt to provide a critical overview of the link between PRL, autoimmune diseases, and motherhood.Frontiers Media S.A.2018info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/107610http://hdl.handle.net/10316/107610https://doi.org/10.3389/fimmu.2018.00073eng1664-3224Borba, Vânia VieiraZandman-Goddard, GiseleShoenfeld, Yehudainfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T09:28:18Zoai:estudogeral.uc.pt:10316/107610Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:23:56.640864Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Prolactin and Autoimmunity |
title |
Prolactin and Autoimmunity |
spellingShingle |
Prolactin and Autoimmunity Borba, Vânia Vieira sex hormones prolactin autoimmunity systemic lupus erythematosus multiple sclerosis systemic sclerosis Animals Autoantibodies Autoimmune Diseases Cytokines Female Gonadal Steroid Hormones Humans Hyperprolactinemia Pregnancy Prolactin Sex Factors Autoimmunity |
title_short |
Prolactin and Autoimmunity |
title_full |
Prolactin and Autoimmunity |
title_fullStr |
Prolactin and Autoimmunity |
title_full_unstemmed |
Prolactin and Autoimmunity |
title_sort |
Prolactin and Autoimmunity |
author |
Borba, Vânia Vieira |
author_facet |
Borba, Vânia Vieira Zandman-Goddard, Gisele Shoenfeld, Yehuda |
author_role |
author |
author2 |
Zandman-Goddard, Gisele Shoenfeld, Yehuda |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Borba, Vânia Vieira Zandman-Goddard, Gisele Shoenfeld, Yehuda |
dc.subject.por.fl_str_mv |
sex hormones prolactin autoimmunity systemic lupus erythematosus multiple sclerosis systemic sclerosis Animals Autoantibodies Autoimmune Diseases Cytokines Female Gonadal Steroid Hormones Humans Hyperprolactinemia Pregnancy Prolactin Sex Factors Autoimmunity |
topic |
sex hormones prolactin autoimmunity systemic lupus erythematosus multiple sclerosis systemic sclerosis Animals Autoantibodies Autoimmune Diseases Cytokines Female Gonadal Steroid Hormones Humans Hyperprolactinemia Pregnancy Prolactin Sex Factors Autoimmunity |
description |
The great asymmetry of autoimmune diseases between genders represents one of the most enigmatic observations among the mosaic of autoimmunity. Sex hormones are believed to play a crucial role on this dimorphism. The higher prevalence of autoimmunity among women at childbearing ages, disease onset/relapses during pregnancy, and post-partum are some of the arguments that support this hypothesis. Certainly, motherhood represents one of the most remarkable challenges for the immune system, which not only has to allow for the conceptus, but also has to deal with complex endocrine alterations. Hormonal homeostasis is known to exert a crucial influence in achieving a competent and healthy immune system. Prolactin (PRL) has a bioactive function acting as a hormone and a cytokine. It interferes with immune system modulation, mainly inhibiting the negative selection of autoreactive B lymphocytes. Likewise, hyperprolactinemia has been described in relation to the pathogenesis and activity of several autoimmune disorders. Dopamine is an effective inhibitor of PRL secretion due to either a direct influence on the hypophysis or stimulation of postsynaptic dopamine receptors in the hypothalamus, arousing the release of the PRL inhibitory factor. Hence, dopamine agonists have proven to offer clinical benefits among autoimmune patients and represent a promising therapy to be explored. In this review, we attempt to provide a critical overview of the link between PRL, autoimmune diseases, and motherhood. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/107610 http://hdl.handle.net/10316/107610 https://doi.org/10.3389/fimmu.2018.00073 |
url |
http://hdl.handle.net/10316/107610 https://doi.org/10.3389/fimmu.2018.00073 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
1664-3224 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Frontiers Media S.A. |
publisher.none.fl_str_mv |
Frontiers Media S.A. |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799134125232226305 |