Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview

Detalhes bibliográficos
Autor(a) principal: Alvito, Paula
Data de Publicação: 2022
Outros Autores: Pereira-da-Silva, Luís
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8504
Resumo: This article belongs to the Special Issue Human Biomonitoring and Risk Assessment of Mycotoxins.
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spelling Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical OverviewMycotoxinsEarly-life ExposureChildrenAdverse Pregnancy OutcomesBaby FoodsBreast MilkHuman BiomonitoringToxicologiaThis article belongs to the Special Issue Human Biomonitoring and Risk Assessment of Mycotoxins.ReviewThe first 1000 days of life are very sensitive to any event that alters health programming, and they represent a window for intervention to improve population health. Pregnant women, fetuses, and infants are particularly vulnerable to exposure to food contaminated with mycotoxins. This review aimed to gather data from the literature on mycotoxins exposure during intrauterine life and early childhood, and associated health risks, as assessed through human biomonitoring and mycotoxins occurrence in foods, in different continents. Maternal internal exposure to aflatoxins is associated with fetal growth restriction, while exposure to fumonisins increases the risk of offspring’s neural tube defects. Mycotoxin contamination of breast milk is reported worldwide, but data on adverse effects of the lactational transfer of mycotoxins on infant health are lacking. Young children are exposed to mycotoxins through contaminated infant formulas and baby foods. Both external and internal exposure to aflatoxins and fumonisins in children are reported to be associated with growth impairment. In low-income settings, where other co-factors can affect growth, this association should be interpreted with caution. Further studies on human biomonitoring of mother–infant pairs and young children are needed to guide management strategies aiming to minimize mycotoxin exposure at critical developmental stages.Key Contribution: Exposure to mycotoxins in early life; impact of mycotoxin exposure on fetal and children’s healthThanks are due to FCT/MCTES for the financial support for the early MYCO project (PTDC/DTP-MEDTOX/28762/2017) and to CESAM (UIDP/50017/2020+UIDB/50017/2020+ LA/P/0094/2020), through national funds.MDPIRepositório Científico do Instituto Nacional de SaúdeAlvito, PaulaPereira-da-Silva, Luís2023-02-06T15:10:40Z2022-03-042022-03-04T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8504engToxins (Basel). 2022 Mar 4;14(3):189. doi: 10.3390/toxins14030189. Review2072-665110.3390/toxins14030189info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:36Zoai:repositorio.insa.pt:10400.18/8504Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:43:08.453224Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
title Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
spellingShingle Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
Alvito, Paula
Mycotoxins
Early-life Exposure
Children
Adverse Pregnancy Outcomes
Baby Foods
Breast Milk
Human Biomonitoring
Toxicologia
title_short Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
title_full Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
title_fullStr Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
title_full_unstemmed Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
title_sort Mycotoxin Exposure during the First 1000 Days of Life and Its Impact on Children’s Health: A Clinical Overview
author Alvito, Paula
author_facet Alvito, Paula
Pereira-da-Silva, Luís
author_role author
author2 Pereira-da-Silva, Luís
author2_role author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Alvito, Paula
Pereira-da-Silva, Luís
dc.subject.por.fl_str_mv Mycotoxins
Early-life Exposure
Children
Adverse Pregnancy Outcomes
Baby Foods
Breast Milk
Human Biomonitoring
Toxicologia
topic Mycotoxins
Early-life Exposure
Children
Adverse Pregnancy Outcomes
Baby Foods
Breast Milk
Human Biomonitoring
Toxicologia
description This article belongs to the Special Issue Human Biomonitoring and Risk Assessment of Mycotoxins.
publishDate 2022
dc.date.none.fl_str_mv 2022-03-04
2022-03-04T00:00:00Z
2023-02-06T15:10:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8504
url http://hdl.handle.net/10400.18/8504
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxins (Basel). 2022 Mar 4;14(3):189. doi: 10.3390/toxins14030189. Review
2072-6651
10.3390/toxins14030189
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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