Alzheimer's disease BIN1 coding variants increase intracellular Aβ levels by interfering with BACE1 recycling

• Autor(a) principal: Perdigão, Catarina
• Data de Publicação: 2021
• Outros Autores: Barata, Mariana A., Burrinha, Tatiana, Almeida, Cláudia Guimas
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10362/125755
• topic: Biochemistry; Molecular Biology; Cell Biology

Funding Information: Funding and additional information—C. G. A. has obtained funding from Maratona da Saúde 2016; CEECIND/00410/2017 financed by FCT (Portugal); ALZ AARG-19–618007 (Alzheimer’s Association); the European Union’s Horizon 2020 research and innovation program under grant agreement No 811087 (Lysocil). C. B. P. was the recipient of an FCT doctoral fellowship (PD/BD/128374/2017). T. B. is the recipient of an FCT doctoral fellowship (SFRH/BD/131513/ 2017). M. A. B. is the recipient of an FCT doctoral fellowship (2020.06758.BD). Funding Information: C. G. A. has obtained funding from Maratona da Sa?de 2016; CEECIND/00410/2017 financed by FCT (Portugal); ALZ AARG-19-618007 (Alzheimer's Association); the European Union's Horizon 2020 research and innovation program under grant agreement No 811087 (Lysocil). C. B. P. was the recipient of an FCT doctoral fellowship (PD/BD/128374/2017). T. B. is the recipient of an FCT doctoral fellowship (SFRH/BD/131513/ 2017). M. A. B. is the recipient of an FCT doctoral fellowship (2020.06758.BD). Funding Information: Acknowledgments—We thank M. Arpin (I Curie) and Z. Lenkei (ESPCI-ParisTech) for the gift of plasmids and cells, respectively. We thank Ana Cláudia Marques for her preliminary observations and lab members for helpful discussions and critical reading of the manuscript. We thank S. Marques (CEDOC Animal Facility), T. Pereira (CEDOC Microscopy Facility), and Ana Oliveira (CEDOC Cell Culture Facility) for their technical assistance. This project has received institutional funding from iNOVA4Health— UID/Multi/ 04462/2019; H2020-WIDESPREAD-01-2016-2017-TeamingPhase2 - GA739572; the research infrastructure PPBI-POCI-01-0145-FEDER-022122, co-financed by FCT (Portugal) and Lisboa2020, under the PORTUGAL2020 agreement (European Regional Development Fund). Publisher Copyright: © 2021 THE AUTHORS. Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).