The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/57853 |
Resumo: | In recent years, we have witnessed a significant increase in the amount of studies using Mesenchymal Stem Cells (MSCs) for cancer therapy, mostly as vectors for drug or gene delivery strategies. This is because of their intrinsic capacity of homing into tumor niches. However, the interactions between MSCs themselves and tumor cells is not fully understood, with contradictory results frequently being observed regarding their effects on cancer cell invasion and proliferation. This poses an important question of safety in respect to the application of these cells. The source of the MSC population used, as well as the type of cancer cells under study might strongly influence this interaction. Moreover, differences in isolation protocols, culture media compositions, time of culture and conditioned media collection, or even timing and mode of MSCs administration to in vivo models of cancer may also affect the interaction MSC-tumor cells. In this review, we drive our focus into malignant brain tumors, particularly gliomas, one of the deadliest forms of cancer. Moreover, we look with some detail into different studies using MSCs as a treatment for brain tumors and compare them, highlighting the main deviations and similarities among them. |
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The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomasAnimalsBrain NeoplasmsGliomaHumansMesenchymal Stem CellsNeoplasm InvasivenessGene Transfer TechniquesMesenchymal Stem Cell TransplantationCancer therapyGlioblastomaSecretomeCiências Médicas::Medicina BásicaScience & TechnologyIn recent years, we have witnessed a significant increase in the amount of studies using Mesenchymal Stem Cells (MSCs) for cancer therapy, mostly as vectors for drug or gene delivery strategies. This is because of their intrinsic capacity of homing into tumor niches. However, the interactions between MSCs themselves and tumor cells is not fully understood, with contradictory results frequently being observed regarding their effects on cancer cell invasion and proliferation. This poses an important question of safety in respect to the application of these cells. The source of the MSC population used, as well as the type of cancer cells under study might strongly influence this interaction. Moreover, differences in isolation protocols, culture media compositions, time of culture and conditioned media collection, or even timing and mode of MSCs administration to in vivo models of cancer may also affect the interaction MSC-tumor cells. In this review, we drive our focus into malignant brain tumors, particularly gliomas, one of the deadliest forms of cancer. Moreover, we look with some detail into different studies using MSCs as a treatment for brain tumors and compare them, highlighting the main deviations and similarities among them.Portuguese Foundation for Science and Technology: pre- doctoral fellowship to E.D. Gomes (SFRH/BD/103075/2014) and J. Vieira de Castro (SFRH/BD/88121/2012); FCT Investigator Starting Grant to B.M. Costa (IF/00601/2012); FCT Investigator Development Grant to A.J. Salgado (IF/00111/2013). This article has been devel- oped under the scope of the project NORTE-01-0145-FEDER- 000023, supported by the Northern Portugal Regional Operational Programme (NORTE 2020), under the Portugal 2020 Partnership Agreement, through the European Regional Development Fund (FEDER). This work has also been funded by FEDER funds, through the Competitiveness Factors Operational Programme (COMPETE), and by National funds, through the Foundation for Science and Technology (FCT), under the scope of the project POCI-01-0145- FEDER-007038info:eu-repo/semantics/acceptedVersionElsevierUniversidade do MinhoGomes, E. D.Castro, Joana Isabel Martins Cosme VieiraCosta, B. M.Salgado, A. J.2018-122018-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/57853engGomes, E. D., de Castro, J. V., Costa, B. M., & Salgado, A. J. (2018). The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas. Biochimie0300-908410.1016/j.biochi.2018.07.00830031037https://www.sciencedirect.com/science/article/pii/S0300908418302037info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:36:20Zoai:repositorium.sdum.uminho.pt:1822/57853Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:32:23.474933Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
title |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
spellingShingle |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas Gomes, E. D. Animals Brain Neoplasms Glioma Humans Mesenchymal Stem Cells Neoplasm Invasiveness Gene Transfer Techniques Mesenchymal Stem Cell Transplantation Cancer therapy Glioblastoma Secretome Ciências Médicas::Medicina Básica Science & Technology |
title_short |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
title_full |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
title_fullStr |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
title_full_unstemmed |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
title_sort |
The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas |
author |
Gomes, E. D. |
author_facet |
Gomes, E. D. Castro, Joana Isabel Martins Cosme Vieira Costa, B. M. Salgado, A. J. |
author_role |
author |
author2 |
Castro, Joana Isabel Martins Cosme Vieira Costa, B. M. Salgado, A. J. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Gomes, E. D. Castro, Joana Isabel Martins Cosme Vieira Costa, B. M. Salgado, A. J. |
dc.subject.por.fl_str_mv |
Animals Brain Neoplasms Glioma Humans Mesenchymal Stem Cells Neoplasm Invasiveness Gene Transfer Techniques Mesenchymal Stem Cell Transplantation Cancer therapy Glioblastoma Secretome Ciências Médicas::Medicina Básica Science & Technology |
topic |
Animals Brain Neoplasms Glioma Humans Mesenchymal Stem Cells Neoplasm Invasiveness Gene Transfer Techniques Mesenchymal Stem Cell Transplantation Cancer therapy Glioblastoma Secretome Ciências Médicas::Medicina Básica Science & Technology |
description |
In recent years, we have witnessed a significant increase in the amount of studies using Mesenchymal Stem Cells (MSCs) for cancer therapy, mostly as vectors for drug or gene delivery strategies. This is because of their intrinsic capacity of homing into tumor niches. However, the interactions between MSCs themselves and tumor cells is not fully understood, with contradictory results frequently being observed regarding their effects on cancer cell invasion and proliferation. This poses an important question of safety in respect to the application of these cells. The source of the MSC population used, as well as the type of cancer cells under study might strongly influence this interaction. Moreover, differences in isolation protocols, culture media compositions, time of culture and conditioned media collection, or even timing and mode of MSCs administration to in vivo models of cancer may also affect the interaction MSC-tumor cells. In this review, we drive our focus into malignant brain tumors, particularly gliomas, one of the deadliest forms of cancer. Moreover, we look with some detail into different studies using MSCs as a treatment for brain tumors and compare them, highlighting the main deviations and similarities among them. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12 2018-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/57853 |
url |
http://hdl.handle.net/1822/57853 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Gomes, E. D., de Castro, J. V., Costa, B. M., & Salgado, A. J. (2018). The impact of Mesenchymal Stem Cells and their secretome as a treatment for gliomas. Biochimie 0300-9084 10.1016/j.biochi.2018.07.008 30031037 https://www.sciencedirect.com/science/article/pii/S0300908418302037 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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