Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/155247 |
Resumo: | Funding Information: This work was supported in part by Centro de Matematica e Aplicaçoes, UID (MAT/00297/2020), Portuguese Foundation of Science and Technology. Acknowledgments Publisher Copyright: Copyright © 2023 Torrente, Sousa, Guerreiro, Franco, Hernández, Parejo, Sousa, Campo-Cañaveral, Pimentão and Provencio. |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spainearly stagelong-term survivalnon-small cell lung cancerprognostic modelrisk stratificationOncologyCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: This work was supported in part by Centro de Matematica e Aplicaçoes, UID (MAT/00297/2020), Portuguese Foundation of Science and Technology. Acknowledgments Publisher Copyright: Copyright © 2023 Torrente, Sousa, Guerreiro, Franco, Hernández, Parejo, Sousa, Campo-Cañaveral, Pimentão and Provencio.Background: Current prognosis in oncology is reduced to the tumour stage and performance status, leaving out many other factors that may impact the patient´s management. Prognostic stratification of early stage non-small-cell lung cancer (NSCLC) patients with poor prognosis after surgery is of considerable clinical relevance. The objective of this study was to identify clinical factors associated with long-term overall survival in a real-life cohort of patients with stage I-II NSCLC and develop a prognostic model that identifies features associated with poor prognosis and stratifies patients by risk. Methods: This is a cohort study including 505 patients, diagnosed with stage I-II NSCLC, who underwent curative surgical procedures at a tertiary hospital in Madrid, Spain. Results: Median OS (in months) was 63.7 (95% CI, 58.7-68.7) for the whole cohort, 62.4 in patients submitted to surgery and 65 in patients submitted to surgery and adjuvant treatment. The univariate analysis estimated that a female diagnosed with NSCLC has a 0.967 (95% CI 0.936 - 0.999) probability of survival one year after diagnosis and a 0.784 (95% CI 0.712 - 0.863) five years after diagnosis. For males, these probabilities drop to 0.904 (95% CI 0.875 - 0.934) and 0.613 (95% CI 0.566 - 0.665), respectively. Multivariable analysis shows that sex, age at diagnosis, type of treatment, ECOG-PS, and stage are statistically significant variables (p<0.10). According to the Cox regression model, age over 50, ECOG-PS 1 or 2, and stage ll are risk factors for survival (HR>1) while adjuvant chemotherapy is a good prognostic variable (HR<1). The prognostic model identified a high-risk profile defined by males over 71 years old, former smokers, treated with surgery, ECOG-PS 2. Conclusions: The results of the present study found that, overall, adjuvant chemotherapy was associated with the best long-term OS in patients with resected NSCLC. Age, stage and ECOG-PS were also significant factors to take into account when making decisions regarding adjuvant therapy.DEE - Departamento de Engenharia Electrotécnica e de ComputadoresCMA - Centro de Matemática e AplicaçõesDM - Departamento de MatemáticaRUNTorrente, MariaSousa, Pedro A.Guerreiro, Gracinda R.Franco, FabioHernández, RobertoParejo, ConsueloSousa, AlexandreCampo-Cañaveral, José LuisPimentão, JoãoProvencio, Mariano2023-07-13T22:18:10Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article12application/pdfhttp://hdl.handle.net/10362/155247eng2234-943XPURE: 66129096https://doi.org/10.3389/fonc.2023.1074337info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:37:47Zoai:run.unl.pt:10362/155247Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:55:59.643641Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| title |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| spellingShingle |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain Torrente, Maria early stage long-term survival non-small cell lung cancer prognostic model risk stratification Oncology Cancer Research SDG 3 - Good Health and Well-being |
| title_short |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| title_full |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| title_fullStr |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| title_full_unstemmed |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| title_sort |
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain |
| author |
Torrente, Maria |
| author_facet |
Torrente, Maria Sousa, Pedro A. Guerreiro, Gracinda R. Franco, Fabio Hernández, Roberto Parejo, Consuelo Sousa, Alexandre Campo-Cañaveral, José Luis Pimentão, João Provencio, Mariano |
| author_role |
author |
| author2 |
Sousa, Pedro A. Guerreiro, Gracinda R. Franco, Fabio Hernández, Roberto Parejo, Consuelo Sousa, Alexandre Campo-Cañaveral, José Luis Pimentão, João Provencio, Mariano |
| author2_role |
author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
DEE - Departamento de Engenharia Electrotécnica e de Computadores CMA - Centro de Matemática e Aplicações DM - Departamento de Matemática RUN |
| dc.contributor.author.fl_str_mv |
Torrente, Maria Sousa, Pedro A. Guerreiro, Gracinda R. Franco, Fabio Hernández, Roberto Parejo, Consuelo Sousa, Alexandre Campo-Cañaveral, José Luis Pimentão, João Provencio, Mariano |
| dc.subject.por.fl_str_mv |
early stage long-term survival non-small cell lung cancer prognostic model risk stratification Oncology Cancer Research SDG 3 - Good Health and Well-being |
| topic |
early stage long-term survival non-small cell lung cancer prognostic model risk stratification Oncology Cancer Research SDG 3 - Good Health and Well-being |
| description |
Funding Information: This work was supported in part by Centro de Matematica e Aplicaçoes, UID (MAT/00297/2020), Portuguese Foundation of Science and Technology. Acknowledgments Publisher Copyright: Copyright © 2023 Torrente, Sousa, Guerreiro, Franco, Hernández, Parejo, Sousa, Campo-Cañaveral, Pimentão and Provencio. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07-13T22:18:10Z 2023 2023-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/155247 |
| url |
http://hdl.handle.net/10362/155247 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
2234-943X PURE: 66129096 https://doi.org/10.3389/fonc.2023.1074337 |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
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12 application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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