Determination of essential biomarkers in lung cancer
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10362/146094 |
Resumo: | Funding Information: This study was supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement n° 875160 CLARIFY project. Funding Information: The authors thank all investigators who participated in the RRTT registry: Dr. Pilar Diaz (Complejo Asistencial Universitario de León, Spain), Dr. Rosa M. Villatoro (Hospital Costa del Sol, Marbella, Spain), Dr. Pilar Lianes (Hospital de Mataró, Barcelona, Spain), Dr. M. Rosario Hernández (Hospital Ntra. Sra Sonsoles, Ávila, Spain), Dr. Juana Oramas (Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain), Dr. Karmele Areses (Complejo Hospitalario e Ourense, Spain), Dr. Rafael Lopez (Hospital Clinico Universitario de Valladolid, Spain), Dr. Julio Ocaña (Hospital CIMA Sanitas, Barcelona, Spain), Dra. María Gonzalez Cao (Hospital Universario Quiron-Dexeus, Barcelona, Spain), Dr. Noemí Reguart (Hospital Clinic Barcelona, Spain), Dr. Manuel Fernández (Hospital HM la Esperanza, Santiago de Compostela, A Coruña, Spain), Dr. Luis Enrique Chara (Hospital Universitario de Guadalajara, Spain), Dr. Judit Rubio (Hospital Universitario de Móstoles, Madrid, Spain), Dr. Alfonso Gurpide (Clinica Universitaria de Navarra, Pamplona, Spain), Dr. Ana Reyes García (Hospital Universitario Río Hortega, Valladolid, Spain), Dr. Beatriz Esteban (Hospital General de Segovia, Spain). We also thank the patients, their families, all the participating clinical teams and the Spanish Lung Cancer Group for coordinating the study. M.P. contributed to the conception and design of the study. D.R.A., M.T., A.LO., C.C., V.C., M.D., G.B., A.P., A.C., R.B., R.G.C., E.C., B.M., J.B.B., O.J.V., M.C., E.d.B., R.L.C., J.L.G., A.S., M.G., R.L.C., J.C., J.O., M.A.S., J.M.T., R.B., J.C., and I.M. contributed to acquisition of study data. M.P. and M.T. contributed to data analysis and writing of the manuscript, J. P. and P.A.S. to the writing and revision. All authors had full access to all the data in the study and final responsibility for the decision to submit for publication. The author(s) read and approved the final manuscript. Publisher Copyright: © 2022, The Author(s). |
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Determination of essential biomarkers in lung cancera real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristicsBiomarkersMetastatic lung cancerTargeted therapiesTestingOncologyGeneticsCancer ResearchSDG 3 - Good Health and Well-beingFunding Information: This study was supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement n° 875160 CLARIFY project. Funding Information: The authors thank all investigators who participated in the RRTT registry: Dr. Pilar Diaz (Complejo Asistencial Universitario de León, Spain), Dr. Rosa M. Villatoro (Hospital Costa del Sol, Marbella, Spain), Dr. Pilar Lianes (Hospital de Mataró, Barcelona, Spain), Dr. M. Rosario Hernández (Hospital Ntra. Sra Sonsoles, Ávila, Spain), Dr. Juana Oramas (Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain), Dr. Karmele Areses (Complejo Hospitalario e Ourense, Spain), Dr. Rafael Lopez (Hospital Clinico Universitario de Valladolid, Spain), Dr. Julio Ocaña (Hospital CIMA Sanitas, Barcelona, Spain), Dra. María Gonzalez Cao (Hospital Universario Quiron-Dexeus, Barcelona, Spain), Dr. Noemí Reguart (Hospital Clinic Barcelona, Spain), Dr. Manuel Fernández (Hospital HM la Esperanza, Santiago de Compostela, A Coruña, Spain), Dr. Luis Enrique Chara (Hospital Universitario de Guadalajara, Spain), Dr. Judit Rubio (Hospital Universitario de Móstoles, Madrid, Spain), Dr. Alfonso Gurpide (Clinica Universitaria de Navarra, Pamplona, Spain), Dr. Ana Reyes García (Hospital Universitario Río Hortega, Valladolid, Spain), Dr. Beatriz Esteban (Hospital General de Segovia, Spain). We also thank the patients, their families, all the participating clinical teams and the Spanish Lung Cancer Group for coordinating the study. M.P. contributed to the conception and design of the study. D.R.A., M.T., A.LO., C.C., V.C., M.D., G.B., A.P., A.C., R.B., R.G.C., E.C., B.M., J.B.B., O.J.V., M.C., E.d.B., R.L.C., J.L.G., A.S., M.G., R.L.C., J.C., J.O., M.A.S., J.M.T., R.B., J.C., and I.M. contributed to acquisition of study data. M.P. and M.T. contributed to data analysis and writing of the manuscript, J. P. and P.A.S. to the writing and revision. All authors had full access to all the data in the study and final responsibility for the decision to submit for publication. The author(s) read and approved the final manuscript. Publisher Copyright: © 2022, The Author(s).Background: The survival of patients with lung cancer has substantially increased in the last decade by about 15%. This increase is, basically, due to targeted therapies available for advanced stages and the emergence of immunotherapy itself. This work aims to study the situation of biomarker testing in Spain. Patients and methods: The Thoracic Tumours Registry (TTR) is an observational, prospective, registry-based study that included patients diagnosed with lung cancer and other thoracic tumours, from September 2016 to 2020. This TTR study was sponsored by the Spanish Lung Cancer Group (GECP) Foundation, an independent, scientific, multidisciplinary oncology society that coordinates more than 550 experts and 182 hospitals across the Spanish territory. Results: Nine thousand two hundred thirty-nine patients diagnosed with stage IV non-small cell lung cancer (NSCLC) between 2106 and 2020 were analysed. 7,467 (80.8%) were non-squamous and 1,772 (19.2%) were squamous. Tumour marker testing was performed in 85.0% of patients with non-squamous tumours vs 56.3% in those with squamous tumours (p-value < 0.001). The global testing of EGFR, ALK, and ROS1 was 78.9, 64.7, 35.6% respectively, in non-squamous histology. PDL1 was determined globally in the same period (46.9%), although if we focus on the last 3 years it exceeds 85%. There has been a significant increase in the last few years of all determinations and there are even close to 10% of molecular determinations that do not yet have targeted drug approval but will have it in the near future. 4,115 cases had a positive result (44.5%) for either EGFR, ALK, KRAS, BRAF, ROS1, or high PDL1. Conclusions: Despite the lack of a national project and standard protocol in Spain that regulates the determination of biomarkers, the situation is similar to other European countries. Given the growing number of different determinations and their high positivity, national strategies are urgently needed to implement next-generation sequencing (NGS) in an integrated and cost-effective way in lung cancer.DEE - Departamento de Engenharia Electrotécnica e de ComputadoresRUNProvencio, MarianoCobo, ManuelRodriguez-Abreu, DelvysCalvo, VirginiaCarcereny, EnricCantero, AlexandraBernabé, ReyesBenitez, GretelCastro, Rafael LópezMassutí, Bartomeudel Barco, EdelGarcía Campelo, RosarioGuirado, MariaCamps, CarlosOrtega, Ana LauraGonzález Larriba, Jose LuisSánchez, AlfredoCasal, JoaquínSala, M. AngelesJuan-Vidal, OscarBosch-Barrera, JoaquimOramas, JuanaDómine, ManuelTrigo, Jose ManuelBlanco, RemeiCalzas, JuliaMorilla, IdoiaPadilla, AiramPimentão, JoãoSousa, Pedro A.Torrente, Maria2022-12-09T22:14:37Z2022-122022-12-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article11application/pdfhttp://hdl.handle.net/10362/146094eng1471-2407PURE: 45463480https://doi.org/10.1186/s12885-022-09830-8info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T18:07:15Zoai:run.unl.pt:10362/146094Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T18:07:15Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Determination of essential biomarkers in lung cancer a real-world data study in Spain with demographic, clinical, epidemiological and pathological characteristics |
title |
Determination of essential biomarkers in lung cancer |
spellingShingle |
Determination of essential biomarkers in lung cancer Provencio, Mariano Biomarkers Metastatic lung cancer Targeted therapies Testing Oncology Genetics Cancer Research SDG 3 - Good Health and Well-being |
title_short |
Determination of essential biomarkers in lung cancer |
title_full |
Determination of essential biomarkers in lung cancer |
title_fullStr |
Determination of essential biomarkers in lung cancer |
title_full_unstemmed |
Determination of essential biomarkers in lung cancer |
title_sort |
Determination of essential biomarkers in lung cancer |
author |
Provencio, Mariano |
author_facet |
Provencio, Mariano Cobo, Manuel Rodriguez-Abreu, Delvys Calvo, Virginia Carcereny, Enric Cantero, Alexandra Bernabé, Reyes Benitez, Gretel Castro, Rafael López Massutí, Bartomeu del Barco, Edel García Campelo, Rosario Guirado, Maria Camps, Carlos Ortega, Ana Laura González Larriba, Jose Luis Sánchez, Alfredo Casal, Joaquín Sala, M. Angeles Juan-Vidal, Oscar Bosch-Barrera, Joaquim Oramas, Juana Dómine, Manuel Trigo, Jose Manuel Blanco, Remei Calzas, Julia Morilla, Idoia Padilla, Airam Pimentão, João Sousa, Pedro A. Torrente, Maria |
author_role |
author |
author2 |
Cobo, Manuel Rodriguez-Abreu, Delvys Calvo, Virginia Carcereny, Enric Cantero, Alexandra Bernabé, Reyes Benitez, Gretel Castro, Rafael López Massutí, Bartomeu del Barco, Edel García Campelo, Rosario Guirado, Maria Camps, Carlos Ortega, Ana Laura González Larriba, Jose Luis Sánchez, Alfredo Casal, Joaquín Sala, M. Angeles Juan-Vidal, Oscar Bosch-Barrera, Joaquim Oramas, Juana Dómine, Manuel Trigo, Jose Manuel Blanco, Remei Calzas, Julia Morilla, Idoia Padilla, Airam Pimentão, João Sousa, Pedro A. Torrente, Maria |
author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
DEE - Departamento de Engenharia Electrotécnica e de Computadores RUN |
dc.contributor.author.fl_str_mv |
Provencio, Mariano Cobo, Manuel Rodriguez-Abreu, Delvys Calvo, Virginia Carcereny, Enric Cantero, Alexandra Bernabé, Reyes Benitez, Gretel Castro, Rafael López Massutí, Bartomeu del Barco, Edel García Campelo, Rosario Guirado, Maria Camps, Carlos Ortega, Ana Laura González Larriba, Jose Luis Sánchez, Alfredo Casal, Joaquín Sala, M. Angeles Juan-Vidal, Oscar Bosch-Barrera, Joaquim Oramas, Juana Dómine, Manuel Trigo, Jose Manuel Blanco, Remei Calzas, Julia Morilla, Idoia Padilla, Airam Pimentão, João Sousa, Pedro A. Torrente, Maria |
dc.subject.por.fl_str_mv |
Biomarkers Metastatic lung cancer Targeted therapies Testing Oncology Genetics Cancer Research SDG 3 - Good Health and Well-being |
topic |
Biomarkers Metastatic lung cancer Targeted therapies Testing Oncology Genetics Cancer Research SDG 3 - Good Health and Well-being |
description |
Funding Information: This study was supported by the European Union Horizon 2020 Research and Innovation Program under grant agreement n° 875160 CLARIFY project. Funding Information: The authors thank all investigators who participated in the RRTT registry: Dr. Pilar Diaz (Complejo Asistencial Universitario de León, Spain), Dr. Rosa M. Villatoro (Hospital Costa del Sol, Marbella, Spain), Dr. Pilar Lianes (Hospital de Mataró, Barcelona, Spain), Dr. M. Rosario Hernández (Hospital Ntra. Sra Sonsoles, Ávila, Spain), Dr. Juana Oramas (Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain), Dr. Karmele Areses (Complejo Hospitalario e Ourense, Spain), Dr. Rafael Lopez (Hospital Clinico Universitario de Valladolid, Spain), Dr. Julio Ocaña (Hospital CIMA Sanitas, Barcelona, Spain), Dra. María Gonzalez Cao (Hospital Universario Quiron-Dexeus, Barcelona, Spain), Dr. Noemí Reguart (Hospital Clinic Barcelona, Spain), Dr. Manuel Fernández (Hospital HM la Esperanza, Santiago de Compostela, A Coruña, Spain), Dr. Luis Enrique Chara (Hospital Universitario de Guadalajara, Spain), Dr. Judit Rubio (Hospital Universitario de Móstoles, Madrid, Spain), Dr. Alfonso Gurpide (Clinica Universitaria de Navarra, Pamplona, Spain), Dr. Ana Reyes García (Hospital Universitario Río Hortega, Valladolid, Spain), Dr. Beatriz Esteban (Hospital General de Segovia, Spain). We also thank the patients, their families, all the participating clinical teams and the Spanish Lung Cancer Group for coordinating the study. M.P. contributed to the conception and design of the study. D.R.A., M.T., A.LO., C.C., V.C., M.D., G.B., A.P., A.C., R.B., R.G.C., E.C., B.M., J.B.B., O.J.V., M.C., E.d.B., R.L.C., J.L.G., A.S., M.G., R.L.C., J.C., J.O., M.A.S., J.M.T., R.B., J.C., and I.M. contributed to acquisition of study data. M.P. and M.T. contributed to data analysis and writing of the manuscript, J. P. and P.A.S. to the writing and revision. All authors had full access to all the data in the study and final responsibility for the decision to submit for publication. The author(s) read and approved the final manuscript. Publisher Copyright: © 2022, The Author(s). |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-12-09T22:14:37Z 2022-12 2022-12-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
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http://hdl.handle.net/10362/146094 |
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http://hdl.handle.net/10362/146094 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.relation.none.fl_str_mv |
1471-2407 PURE: 45463480 https://doi.org/10.1186/s12885-022-09830-8 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
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openAccess |
dc.format.none.fl_str_mv |
11 application/pdf |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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