Nanoparticles based on novel carbohydrate-functionalized polymers

Detalhes bibliográficos
Autor(a) principal: Raposo, Cláudia D.
Data de Publicação: 2020
Outros Autores: Conceição, Cristiano A., Barros, Maria Teresa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/117030
Resumo: PD/BD/109680/2015 UID/QUI/50006/2019 POCI-01-0145-FEDER-007265
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spelling Nanoparticles based on novel carbohydrate-functionalized polymersCoumarinsDrug delivery systemsGalactoseGlucoseMannosePEGPLGAPolymeric nanoparticlesThymidineAnalytical ChemistryChemistry (miscellaneous)Molecular MedicinePharmaceutical ScienceDrug DiscoveryPhysical and Theoretical ChemistryOrganic ChemistryPD/BD/109680/2015 UID/QUI/50006/2019 POCI-01-0145-FEDER-007265Polymeric nanoparticles can be used for drug delivery systems in healthcare. For this purpose poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) offer an excellent polymeric matrix. In this work, PLGA and PEG polymers were functionalized with coumarin and carbohydrate moieties such as thymidine, glucose, galactose, and mannose that have high biological specificities. Using a single oil in water emulsion methodology, functionalized PLGA nanoparticles were prepared having a smooth surface and sizes ranging between 114-289 nm, a low polydispersity index and a zeta potential from -28.2 to -56.0mV. However, for the corresponding PEG derivatives the polymers obtained were produced in the form of films due to the small size of the hydrophobic core.DQ - Departamento de QuímicaLAQV@REQUIMTERUNRaposo, Cláudia D.Conceição, Cristiano A.Barros, Maria Teresa2021-05-04T22:55:33Z2020-04-102020-04-10T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/117030engPURE: 26695737https://doi.org/10.3390/molecules25071744info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:59:58Zoai:run.unl.pt:10362/117030Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:43:26.106648Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Nanoparticles based on novel carbohydrate-functionalized polymers
title Nanoparticles based on novel carbohydrate-functionalized polymers
spellingShingle Nanoparticles based on novel carbohydrate-functionalized polymers
Raposo, Cláudia D.
Coumarins
Drug delivery systems
Galactose
Glucose
Mannose
PEG
PLGA
Polymeric nanoparticles
Thymidine
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
title_short Nanoparticles based on novel carbohydrate-functionalized polymers
title_full Nanoparticles based on novel carbohydrate-functionalized polymers
title_fullStr Nanoparticles based on novel carbohydrate-functionalized polymers
title_full_unstemmed Nanoparticles based on novel carbohydrate-functionalized polymers
title_sort Nanoparticles based on novel carbohydrate-functionalized polymers
author Raposo, Cláudia D.
author_facet Raposo, Cláudia D.
Conceição, Cristiano A.
Barros, Maria Teresa
author_role author
author2 Conceição, Cristiano A.
Barros, Maria Teresa
author2_role author
author
dc.contributor.none.fl_str_mv DQ - Departamento de Química
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Raposo, Cláudia D.
Conceição, Cristiano A.
Barros, Maria Teresa
dc.subject.por.fl_str_mv Coumarins
Drug delivery systems
Galactose
Glucose
Mannose
PEG
PLGA
Polymeric nanoparticles
Thymidine
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
topic Coumarins
Drug delivery systems
Galactose
Glucose
Mannose
PEG
PLGA
Polymeric nanoparticles
Thymidine
Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry
description PD/BD/109680/2015 UID/QUI/50006/2019 POCI-01-0145-FEDER-007265
publishDate 2020
dc.date.none.fl_str_mv 2020-04-10
2020-04-10T00:00:00Z
2021-05-04T22:55:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/117030
url http://hdl.handle.net/10362/117030
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PURE: 26695737
https://doi.org/10.3390/molecules25071744
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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