The Importance of Zebrafish in Biomedical Research

Detalhes bibliográficos
Autor(a) principal: Santos, Ana Bárbara Tavares dos
Data de Publicação: 2013
Outros Autores: Lopes, Susana Santos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/21647
Resumo: FUNDING SOURCE - PTDC/SAU-OBD/103981/2008 and SFRH/BPD/772587/2011
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spelling The Importance of Zebrafish in Biomedical ResearchTUMOR ANGIOGENESISDisease Models, AnimalT-CELL LEUKEMIADANIO-RERIODrug Evaluation, PreclinicalDIFFERENT DEVELOPMENTAL-STAGESMODEL ORGANISMDRUG SCREENSLIVER DEVELOPMENTEXPOSURE ROUTESBiomedical ResearchZebrafishIN-VIVOTRANSGENIC ZEBRAFISHSDG 3 - Good Health and Well-beingFUNDING SOURCE - PTDC/SAU-OBD/103981/2008 and SFRH/BPD/772587/2011Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are small, transparent and undergo rapid external development. Material and Methods: Using scientific literature research tools available online and the keywords Zebrafish, biomedical research, human disease, and drug screening, we reviewed original studies and reviews indexed in PubMed. Results: In this review we summarized work conducted with this model for the advancement of our knowledge related to several human diseases. We also focused on the biomedical research being performed in Portugal with the zebrafish model. Discussion: Powerful live imaging and genetic tools are currently available for zebrafish making it a valuable model in biomedical research. The combination of these properties with the optimization of automated systems for drug screening has transformed the zebrafish into "a top model" in biomedical research, drug discovery and toxicity testing. Furthermore, with the optimization of xenografts technology it will be possible to use zebrafish to aide in the choice of the best therapy for each patient. Conclusion: Zebrafish is an excellent model organism in biomedical research, drug development and in clinical therapy.Centro de Estudos de Doenças Crónicas (CEDOC)NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNSantos, Ana Bárbara Tavares dosLopes, Susana Santos2017-06-21T22:01:05Z2013-092013-09-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttp://hdl.handle.net/10362/21647eng1646-0758PURE: 297200info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:08:33Zoai:run.unl.pt:10362/21647Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:26:54.704674Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Importance of Zebrafish in Biomedical Research
title The Importance of Zebrafish in Biomedical Research
spellingShingle The Importance of Zebrafish in Biomedical Research
Santos, Ana Bárbara Tavares dos
TUMOR ANGIOGENESIS
Disease Models, Animal
T-CELL LEUKEMIA
DANIO-RERIO
Drug Evaluation, Preclinical
DIFFERENT DEVELOPMENTAL-STAGES
MODEL ORGANISM
DRUG SCREENS
LIVER DEVELOPMENT
EXPOSURE ROUTES
Biomedical Research
Zebrafish
IN-VIVO
TRANSGENIC ZEBRAFISH
SDG 3 - Good Health and Well-being
title_short The Importance of Zebrafish in Biomedical Research
title_full The Importance of Zebrafish in Biomedical Research
title_fullStr The Importance of Zebrafish in Biomedical Research
title_full_unstemmed The Importance of Zebrafish in Biomedical Research
title_sort The Importance of Zebrafish in Biomedical Research
author Santos, Ana Bárbara Tavares dos
author_facet Santos, Ana Bárbara Tavares dos
Lopes, Susana Santos
author_role author
author2 Lopes, Susana Santos
author2_role author
dc.contributor.none.fl_str_mv Centro de Estudos de Doenças Crónicas (CEDOC)
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
RUN
dc.contributor.author.fl_str_mv Santos, Ana Bárbara Tavares dos
Lopes, Susana Santos
dc.subject.por.fl_str_mv TUMOR ANGIOGENESIS
Disease Models, Animal
T-CELL LEUKEMIA
DANIO-RERIO
Drug Evaluation, Preclinical
DIFFERENT DEVELOPMENTAL-STAGES
MODEL ORGANISM
DRUG SCREENS
LIVER DEVELOPMENT
EXPOSURE ROUTES
Biomedical Research
Zebrafish
IN-VIVO
TRANSGENIC ZEBRAFISH
SDG 3 - Good Health and Well-being
topic TUMOR ANGIOGENESIS
Disease Models, Animal
T-CELL LEUKEMIA
DANIO-RERIO
Drug Evaluation, Preclinical
DIFFERENT DEVELOPMENTAL-STAGES
MODEL ORGANISM
DRUG SCREENS
LIVER DEVELOPMENT
EXPOSURE ROUTES
Biomedical Research
Zebrafish
IN-VIVO
TRANSGENIC ZEBRAFISH
SDG 3 - Good Health and Well-being
description FUNDING SOURCE - PTDC/SAU-OBD/103981/2008 and SFRH/BPD/772587/2011
publishDate 2013
dc.date.none.fl_str_mv 2013-09
2013-09-01T00:00:00Z
2017-06-21T22:01:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/21647
url http://hdl.handle.net/10362/21647
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1646-0758
PURE: 297200
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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