Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy

Detalhes bibliográficos
Autor(a) principal: Cuypers, Lize
Data de Publicação: 2017
Outros Autores: Vrancken, Bram, Fabeni, Lavinia, Marascio, Nadia, Cento, Valeria, Di Maio, Velia Chiara, Aragri, Marianna, Pineda-Peña, Andrea Clemencia, Schrooten, Yoeri, Van Laethem, Kristel, Balog, Daniel, Focà, Alfredo, Torti, Carlo, Nevens, Frederik, Perno, Carlo Federico, Vandamme, Anne Mieke, Ceccherini-Silberstein, Francesca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1186/s12862-017-0913-3
Resumo: Background: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data. Results: Our results showed that both immigration and local circulation fuel the current Italian HCV1a epidemic. The United States and European continental lineages dominate import into Italy, with the latter taking the lead from the 1970s onwards. Since similar migration patterns were found for Q80K and other lineages, no clear differentiation of the risk for failing simeprevir can be made between patients based on their migration and travel history. Importantly, since HCV only occasionally recombines, these results are readily transferable to the genetic sequencing policy concerning NS5A RAVs. Conclusions: The patient migration and travel history cannot be used to target only part of the HCV1a infected population for drug resistance testing before start of antiviral therapy. Consequently, it may be cost-effective to expand genotyping efforts to all HCV1a infected patients eligible for simeprevir-based therapies.
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spelling Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in ItalyEuropeHCVHCV1aItalyPhylogeographyPublic health policyQ80KUSEcology, Evolution, Behavior and SystematicsSDG 3 - Good Health and Well-beingSDG 10 - Reduced InequalitiesBackground: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data. Results: Our results showed that both immigration and local circulation fuel the current Italian HCV1a epidemic. The United States and European continental lineages dominate import into Italy, with the latter taking the lead from the 1970s onwards. Since similar migration patterns were found for Q80K and other lineages, no clear differentiation of the risk for failing simeprevir can be made between patients based on their migration and travel history. Importantly, since HCV only occasionally recombines, these results are readily transferable to the genetic sequencing policy concerning NS5A RAVs. Conclusions: The patient migration and travel history cannot be used to target only part of the HCV1a infected population for drug resistance testing before start of antiviral therapy. Consequently, it may be cost-effective to expand genotyping efforts to all HCV1a infected patients eligible for simeprevir-based therapies.Instituto de Higiene e Medicina Tropical (IHMT)Global Health and Tropical Medicine (GHTM)TB, HIV and opportunistic diseases and pathogens (THOP)RUNCuypers, LizeVrancken, BramFabeni, LaviniaMarascio, NadiaCento, ValeriaDi Maio, Velia ChiaraAragri, MariannaPineda-Peña, Andrea ClemenciaSchrooten, YoeriVan Laethem, KristelBalog, DanielFocà, AlfredoTorti, CarloNevens, FrederikPerno, Carlo FedericoVandamme, Anne MiekeCeccherini-Silberstein, Francesca2018-05-10T22:16:04Z2017-03-072017-03-07T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10application/pdfhttps://doi.org/10.1186/s12862-017-0913-3eng1471-2148PURE: 3202562http://www.scopus.com/inward/record.url?scp=85014646353&partnerID=8YFLogxKhttps://doi.org/10.1186/s12862-017-0913-3info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T04:19:51Zoai:run.unl.pt:10362/36468Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:30:30.191245Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
title Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
spellingShingle Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
Cuypers, Lize
Europe
HCV
HCV1a
Italy
Phylogeography
Public health policy
Q80K
US
Ecology, Evolution, Behavior and Systematics
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
title_short Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
title_full Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
title_fullStr Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
title_full_unstemmed Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
title_sort Implications of hepatitis C virus subtype 1a migration patterns for virus genetic sequencing policies in Italy
author Cuypers, Lize
author_facet Cuypers, Lize
Vrancken, Bram
Fabeni, Lavinia
Marascio, Nadia
Cento, Valeria
Di Maio, Velia Chiara
Aragri, Marianna
Pineda-Peña, Andrea Clemencia
Schrooten, Yoeri
Van Laethem, Kristel
Balog, Daniel
Focà, Alfredo
Torti, Carlo
Nevens, Frederik
Perno, Carlo Federico
Vandamme, Anne Mieke
Ceccherini-Silberstein, Francesca
author_role author
author2 Vrancken, Bram
Fabeni, Lavinia
Marascio, Nadia
Cento, Valeria
Di Maio, Velia Chiara
Aragri, Marianna
Pineda-Peña, Andrea Clemencia
Schrooten, Yoeri
Van Laethem, Kristel
Balog, Daniel
Focà, Alfredo
Torti, Carlo
Nevens, Frederik
Perno, Carlo Federico
Vandamme, Anne Mieke
Ceccherini-Silberstein, Francesca
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Global Health and Tropical Medicine (GHTM)
TB, HIV and opportunistic diseases and pathogens (THOP)
RUN
dc.contributor.author.fl_str_mv Cuypers, Lize
Vrancken, Bram
Fabeni, Lavinia
Marascio, Nadia
Cento, Valeria
Di Maio, Velia Chiara
Aragri, Marianna
Pineda-Peña, Andrea Clemencia
Schrooten, Yoeri
Van Laethem, Kristel
Balog, Daniel
Focà, Alfredo
Torti, Carlo
Nevens, Frederik
Perno, Carlo Federico
Vandamme, Anne Mieke
Ceccherini-Silberstein, Francesca
dc.subject.por.fl_str_mv Europe
HCV
HCV1a
Italy
Phylogeography
Public health policy
Q80K
US
Ecology, Evolution, Behavior and Systematics
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
topic Europe
HCV
HCV1a
Italy
Phylogeography
Public health policy
Q80K
US
Ecology, Evolution, Behavior and Systematics
SDG 3 - Good Health and Well-being
SDG 10 - Reduced Inequalities
description Background: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, capitalising on newly generated and publicly available time and geo-referenced NS3 encoding virus genetic sequence data. Results: Our results showed that both immigration and local circulation fuel the current Italian HCV1a epidemic. The United States and European continental lineages dominate import into Italy, with the latter taking the lead from the 1970s onwards. Since similar migration patterns were found for Q80K and other lineages, no clear differentiation of the risk for failing simeprevir can be made between patients based on their migration and travel history. Importantly, since HCV only occasionally recombines, these results are readily transferable to the genetic sequencing policy concerning NS5A RAVs. Conclusions: The patient migration and travel history cannot be used to target only part of the HCV1a infected population for drug resistance testing before start of antiviral therapy. Consequently, it may be cost-effective to expand genotyping efforts to all HCV1a infected patients eligible for simeprevir-based therapies.
publishDate 2017
dc.date.none.fl_str_mv 2017-03-07
2017-03-07T00:00:00Z
2018-05-10T22:16:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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dc.language.iso.fl_str_mv eng
language eng
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PURE: 3202562
http://www.scopus.com/inward/record.url?scp=85014646353&partnerID=8YFLogxK
https://doi.org/10.1186/s12862-017-0913-3
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