Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients

Detalhes bibliográficos
Autor(a) principal: Adragao, T
Data de Publicação: 2017
Outros Autores: Ferreira, A, Frazao, JM, Papoila, AL, Pinto, I, Monier-Faugere, MC, Malluche, HH
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/2914
Resumo: BACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.
id RCAP_acf2ec6beb6564df0615be4967bbc32b
oai_identifier_str oai:repositorio.chlc.min-saude.pt:10400.17/2914
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis PatientsAdultAgedBiopsyBone DevelopmentFemaleHandHumansMaleMiddle AgedPelvisRenal DialysisVascular CalcificationCalcification, PhysiologicTomography, Emission-ComputedHCC NEFBACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.Repositório do Centro Hospitalar Universitário de Lisboa Central, EPEAdragao, TFerreira, AFrazao, JMPapoila, ALPinto, IMonier-Faugere, MCMalluche, HH2018-02-20T15:57:20Z2017-072017-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2914engPLoS One. 2017 Jul 7;12(7):e0179868.10.1371/journal.pone.0179868info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:18Zoai:repositorio.chlc.min-saude.pt:10400.17/2914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:14.420341Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
title Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
spellingShingle Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
Adragao, T
Adult
Aged
Biopsy
Bone Development
Female
Hand
Humans
Male
Middle Aged
Pelvis
Renal Dialysis
Vascular Calcification
Calcification, Physiologic
Tomography, Emission-Computed
HCC NEF
title_short Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
title_full Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
title_fullStr Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
title_full_unstemmed Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
title_sort Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
author Adragao, T
author_facet Adragao, T
Ferreira, A
Frazao, JM
Papoila, AL
Pinto, I
Monier-Faugere, MC
Malluche, HH
author_role author
author2 Ferreira, A
Frazao, JM
Papoila, AL
Pinto, I
Monier-Faugere, MC
Malluche, HH
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Adragao, T
Ferreira, A
Frazao, JM
Papoila, AL
Pinto, I
Monier-Faugere, MC
Malluche, HH
dc.subject.por.fl_str_mv Adult
Aged
Biopsy
Bone Development
Female
Hand
Humans
Male
Middle Aged
Pelvis
Renal Dialysis
Vascular Calcification
Calcification, Physiologic
Tomography, Emission-Computed
HCC NEF
topic Adult
Aged
Biopsy
Bone Development
Female
Hand
Humans
Male
Middle Aged
Pelvis
Renal Dialysis
Vascular Calcification
Calcification, Physiologic
Tomography, Emission-Computed
HCC NEF
description BACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
2017-07-01T00:00:00Z
2018-02-20T15:57:20Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/2914
url http://hdl.handle.net/10400.17/2914
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2017 Jul 7;12(7):e0179868.
10.1371/journal.pone.0179868
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799131298738995200