Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/2914 |
Resumo: | BACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients. |
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Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis PatientsAdultAgedBiopsyBone DevelopmentFemaleHandHumansMaleMiddle AgedPelvisRenal DialysisVascular CalcificationCalcification, PhysiologicTomography, Emission-ComputedHCC NEFBACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients.Repositório do Centro Hospitalar Universitário de Lisboa Central, EPEAdragao, TFerreira, AFrazao, JMPapoila, ALPinto, IMonier-Faugere, MCMalluche, HH2018-02-20T15:57:20Z2017-072017-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/2914engPLoS One. 2017 Jul 7;12(7):e0179868.10.1371/journal.pone.0179868info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:40:18Zoai:repositorio.chlc.min-saude.pt:10400.17/2914Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:14.420341Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
title |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
spellingShingle |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients Adragao, T Adult Aged Biopsy Bone Development Female Hand Humans Male Middle Aged Pelvis Renal Dialysis Vascular Calcification Calcification, Physiologic Tomography, Emission-Computed HCC NEF |
title_short |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
title_full |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
title_fullStr |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
title_full_unstemmed |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
title_sort |
Higher Mineralized Bone Volume Is Associated with a Lower Plain X-Ray Vascular Calcification Score in Hemodialysis Patients |
author |
Adragao, T |
author_facet |
Adragao, T Ferreira, A Frazao, JM Papoila, AL Pinto, I Monier-Faugere, MC Malluche, HH |
author_role |
author |
author2 |
Ferreira, A Frazao, JM Papoila, AL Pinto, I Monier-Faugere, MC Malluche, HH |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Adragao, T Ferreira, A Frazao, JM Papoila, AL Pinto, I Monier-Faugere, MC Malluche, HH |
dc.subject.por.fl_str_mv |
Adult Aged Biopsy Bone Development Female Hand Humans Male Middle Aged Pelvis Renal Dialysis Vascular Calcification Calcification, Physiologic Tomography, Emission-Computed HCC NEF |
topic |
Adult Aged Biopsy Bone Development Female Hand Humans Male Middle Aged Pelvis Renal Dialysis Vascular Calcification Calcification, Physiologic Tomography, Emission-Computed HCC NEF |
description |
BACKGROUND AND OBJECTIVES: In dialysis patients, there is an increasing evidence that altered bone metabolism is associated with cardiovascular calcifications. The main objective of this study was to analyse, in hemodialysis patients, the relationships between bone turnover, mineralization and volume, evaluated in bone biopsies, with a plain X-ray vascular calcification score. DESIGN, SETTING, PARTICIPANTS AND MEASUREMENTS: In a cross-sectional study, bone biopsies and evaluation of vascular calcifications were performed in fifty hemodialysis patients. Cancellous bone volume, mineralized bone volume, osteoid volume, activation frequency, bone formation rate/bone surface, osteoid thickness and mineralization lag time were determined by histomorphometry. Vascular calcifications were assessed by the simple vascular calcification score (SVCS) in plain X-Ray of pelvis and hands and, for comparison, by the Agatston score in Multi-Slice Computed Tomography (MSCT). RESULTS: SVCS≥3 was present in 20 patients (40%). Low and high bone turnover were present in 54% and 38% of patients, respectively. Low bone volume was present in 20% of patients. In multivariable analysis, higher age (p = 0.015) and longer hemodialysis duration (p = 0.017) were associated with SVCS≥3. Contrary to cancellous bone volume, the addition to this model of mineralized bone volume (OR = 0.863; 95%CI: 0.766, 0.971; p = 0.015), improved the performance of the model. For each increase of 1% in mineralized bone volume there was a 13.7% decrease in the odds of having SVCS≥3 (p = 0.015). An Agatston score>400 was observed in 80% of the patients with a SVCS≥3 versus 4% of patients with a SVCS<3, (p<0.001). CONCLUSION: Higher mineralized bone volume was associated with a lower plain X-ray vascular calcification. This study corroborates the hypothesis of the existence of a link between bone and vessel and reinforces the clinical utility of this simple and inexpensive vascular calcification score in dialysis patients. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-07 2017-07-01T00:00:00Z 2018-02-20T15:57:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/2914 |
url |
http://hdl.handle.net/10400.17/2914 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS One. 2017 Jul 7;12(7):e0179868. 10.1371/journal.pone.0179868 |
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info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
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application/pdf |
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