Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging

Detalhes bibliográficos
Autor(a) principal: Silva, Bruna Spolador de Alencar
Data de Publicação: 2021
Outros Autores: Uzeloto, Juliana Souza, Lira, Fábio Santos, Pereira, Telmo, Silva, Manuel J. Coelho e, Caseiro, Armando
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
DOI: 10.3390/ijerph182412949
Texto Completo: http://hdl.handle.net/10316/96711
https://doi.org/10.3390/ijerph182412949
Resumo: Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland
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spelling Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle AgingCircadian rhythmsClock genesInflammationSarcopeniaSkeletal muscle disfunctionVascular disfunctionAging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes. © 2021 by the authors. Licensee MDPI, Basel, SwitzerlandMDPI2021info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/96711http://hdl.handle.net/10316/96711https://doi.org/10.3390/ijerph182412949eng1660-4601Silva, Bruna Spolador de AlencarUzeloto, Juliana SouzaLira, Fábio SantosPereira, TelmoSilva, Manuel J. Coelho eCaseiro, Armandoinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-05-25T06:04:13Zoai:estudogeral.uc.pt:10316/96711Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:14:54.299995Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
title Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
spellingShingle Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
Silva, Bruna Spolador de Alencar
Circadian rhythms
Clock genes
Inflammation
Sarcopenia
Skeletal muscle disfunction
Vascular disfunction
Silva, Bruna Spolador de Alencar
Circadian rhythms
Clock genes
Inflammation
Sarcopenia
Skeletal muscle disfunction
Vascular disfunction
title_short Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
title_full Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
title_fullStr Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
title_full_unstemmed Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
title_sort Exercise as a Peripheral Circadian Clock Resynchronizer in Vascular and Skeletal Muscle Aging
author Silva, Bruna Spolador de Alencar
author_facet Silva, Bruna Spolador de Alencar
Silva, Bruna Spolador de Alencar
Uzeloto, Juliana Souza
Lira, Fábio Santos
Pereira, Telmo
Silva, Manuel J. Coelho e
Caseiro, Armando
Uzeloto, Juliana Souza
Lira, Fábio Santos
Pereira, Telmo
Silva, Manuel J. Coelho e
Caseiro, Armando
author_role author
author2 Uzeloto, Juliana Souza
Lira, Fábio Santos
Pereira, Telmo
Silva, Manuel J. Coelho e
Caseiro, Armando
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Bruna Spolador de Alencar
Uzeloto, Juliana Souza
Lira, Fábio Santos
Pereira, Telmo
Silva, Manuel J. Coelho e
Caseiro, Armando
dc.subject.por.fl_str_mv Circadian rhythms
Clock genes
Inflammation
Sarcopenia
Skeletal muscle disfunction
Vascular disfunction
topic Circadian rhythms
Clock genes
Inflammation
Sarcopenia
Skeletal muscle disfunction
Vascular disfunction
description Aging is characterized by several progressive physiological changes, including changes in the circadian rhythm. Circadian rhythms influence behavior, physiology, and metabolic processes in order to maintain homeostasis; they also influence the function of endothelial cells, smooth muscle cells, and immune cells in the vessel wall. A clock misalignment could favor vascular damage and indirectly also affect skeletal muscle function. In this review, we focus on the dysregulation of circadian rhythm due to aging and its relationship with skeletal muscle changes and vascular health as possible risk factors for the development of sarcopenia, as well as the role of physical exercise as a potential modulator of these processes. © 2021 by the authors. Licensee MDPI, Basel, Switzerland
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/96711
http://hdl.handle.net/10316/96711
https://doi.org/10.3390/ijerph182412949
url http://hdl.handle.net/10316/96711
https://doi.org/10.3390/ijerph182412949
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1660-4601
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.3390/ijerph182412949

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