How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.18/7908 |
Resumo: | Evidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health. |
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How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targetsEpigeneticsNanomaterialsIn vitroIn vivoEpigenetic inheritanceHuman healthGenotoxicidade AmbientalEvidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health.This work was supported by the NanoBioBarriers project (PTDC/MED-TOX/31162/2017), co-financed by the Operational Program for Competitiveness and Internationalization (POCI) through European Regional Development Funds (FEDER/FNR) and through national funds by the Portuguese Foundation for Science and Technology (FCT). Thanks are also due to FCT/MCTES for the financial support to EPIUnit (UIDB/04750/2020).ElsevierRepositório Científico do Instituto Nacional de SaúdeMoreira, LucianaCosta, CarlaPires, JoanaTeixeira, João PauloFraga, Sónia2022-02-01T16:18:56Z2021-06-122021-06-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7908engMutat Res Rev Mutat Res. Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12. Review1383-574210.1016/j.mrrev.2021.108385info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:13Zoai:repositorio.insa.pt:10400.18/7908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:27.318432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
title |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
spellingShingle |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets Moreira, Luciana Epigenetics Nanomaterials In vitro In vivo Epigenetic inheritance Human health Genotoxicidade Ambiental |
title_short |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
title_full |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
title_fullStr |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
title_full_unstemmed |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
title_sort |
How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets |
author |
Moreira, Luciana |
author_facet |
Moreira, Luciana Costa, Carla Pires, Joana Teixeira, João Paulo Fraga, Sónia |
author_role |
author |
author2 |
Costa, Carla Pires, Joana Teixeira, João Paulo Fraga, Sónia |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Moreira, Luciana Costa, Carla Pires, Joana Teixeira, João Paulo Fraga, Sónia |
dc.subject.por.fl_str_mv |
Epigenetics Nanomaterials In vitro In vivo Epigenetic inheritance Human health Genotoxicidade Ambiental |
topic |
Epigenetics Nanomaterials In vitro In vivo Epigenetic inheritance Human health Genotoxicidade Ambiental |
description |
Evidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-12 2021-06-12T00:00:00Z 2022-02-01T16:18:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/7908 |
url |
http://hdl.handle.net/10400.18/7908 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Mutat Res Rev Mutat Res. Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12. Review 1383-5742 10.1016/j.mrrev.2021.108385 |
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info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1817553250799321088 |