How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets

Detalhes bibliográficos
Autor(a) principal: Moreira, Luciana
Data de Publicação: 2021
Outros Autores: Costa, Carla, Pires, Joana, Teixeira, João Paulo, Fraga, Sónia
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/7908
Resumo: Evidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health.
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spelling How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targetsEpigeneticsNanomaterialsIn vitroIn vivoEpigenetic inheritanceHuman healthGenotoxicidade AmbientalEvidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health.This work was supported by the NanoBioBarriers project (PTDC/MED-TOX/31162/2017), co-financed by the Operational Program for Competitiveness and Internationalization (POCI) through European Regional Development Funds (FEDER/FNR) and through national funds by the Portuguese Foundation for Science and Technology (FCT). Thanks are also due to FCT/MCTES for the financial support to EPIUnit (UIDB/04750/2020).ElsevierRepositório Científico do Instituto Nacional de SaúdeMoreira, LucianaCosta, CarlaPires, JoanaTeixeira, João PauloFraga, Sónia2022-02-01T16:18:56Z2021-06-122021-06-12T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/7908engMutat Res Rev Mutat Res. Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12. Review1383-574210.1016/j.mrrev.2021.108385info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:13Zoai:repositorio.insa.pt:10400.18/7908Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:27.318432Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
title How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
spellingShingle How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
Moreira, Luciana
Epigenetics
Nanomaterials
In vitro
In vivo
Epigenetic inheritance
Human health
Genotoxicidade Ambiental
title_short How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
title_full How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
title_fullStr How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
title_full_unstemmed How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
title_sort How can exposure to engineered nanomaterials influence our epigenetic code? A review of the mechanisms and molecular targets
author Moreira, Luciana
author_facet Moreira, Luciana
Costa, Carla
Pires, Joana
Teixeira, João Paulo
Fraga, Sónia
author_role author
author2 Costa, Carla
Pires, Joana
Teixeira, João Paulo
Fraga, Sónia
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Moreira, Luciana
Costa, Carla
Pires, Joana
Teixeira, João Paulo
Fraga, Sónia
dc.subject.por.fl_str_mv Epigenetics
Nanomaterials
In vitro
In vivo
Epigenetic inheritance
Human health
Genotoxicidade Ambiental
topic Epigenetics
Nanomaterials
In vitro
In vivo
Epigenetic inheritance
Human health
Genotoxicidade Ambiental
description Evidence suggests that engineered nanomaterials (ENM) can induce epigenetic modifications. In this review, we provide an overview of the epigenetic modulation of gene expression induced by ENM used in a variety of applications: titanium dioxide (TiO2), silver (Ag), gold (Au), silica (SiO2) nanoparticles and carbon-based nanomaterials (CNM). Exposure to these ENM can trigger alterations in cell patterns of DNA methylation, posttranscriptional histone modifications and expression of non-coding RNA. Such effects are dependent on ENM dose and physicochemical properties including size, shape and surface chemistry, as well as on the cell/organism sensitivity. The genes affected are mostly involved in the regulation of the epigenetic machinery itself, as well as in apoptosis, cell cycle, DNA repair and inflammation related pathways, whose long-term alterations might lead to the onset or progression of certain pathologies. In addition, some DNA methylation patterns may be retained as a form of epigenetic memory. Prenatal exposure to ENM may impair the normal development of the offspring by transplacental effects and/or putative transmission of epimutations in imprinting genes. Thus, understanding the impact of ENM on the epigenome is of paramount importance and epigenetic evaluation must be considered when assessing the risk of ENM to human health.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-12
2021-06-12T00:00:00Z
2022-02-01T16:18:56Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/7908
url http://hdl.handle.net/10400.18/7908
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mutat Res Rev Mutat Res. Jul-Dec 2021;788:108385. doi: 10.1016/j.mrrev.2021.108385. Epub 2021 Jun 12. Review
1383-5742
10.1016/j.mrrev.2021.108385
dc.rights.driver.fl_str_mv info:eu-repo/semantics/embargoedAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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