Natural carriers for application in tuberculosis treatment

Detalhes bibliográficos
Autor(a) principal: Costa, Hugo
Data de Publicação: 2012
Outros Autores: Grenha, Ana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.1/2101
Resumo: Tuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticles have taken the forefront of this approach, providing the means for the desired improvement of therapeutic schedules. Natural polymers are strong candidates as matrix forming materials, usually exhibiting biocompatibility, biodegradability, low cost and some technological advantages as compared with synthetic counterparts. In this review, natural particulate carriers developed for tuberculosis therapy are presented, mainly focusing on the use of polysaccharides and lipids. Their effectiveness is discussed taking into account their composition. Finally, considerations on the general potential of natural materials for this application, as well as key factors still to be addressed, are discussed.
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spelling Natural carriers for application in tuberculosis treatmentControlled releaseDrug deliveryMicroparticlesNanoparticlesMicroencapsulationTuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticles have taken the forefront of this approach, providing the means for the desired improvement of therapeutic schedules. Natural polymers are strong candidates as matrix forming materials, usually exhibiting biocompatibility, biodegradability, low cost and some technological advantages as compared with synthetic counterparts. In this review, natural particulate carriers developed for tuberculosis therapy are presented, mainly focusing on the use of polysaccharides and lipids. Their effectiveness is discussed taking into account their composition. Finally, considerations on the general potential of natural materials for this application, as well as key factors still to be addressed, are discussed.SapientiaCosta, HugoGrenha, Ana2013-01-16T13:58:27Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.1/2101engdoi:10.3109/02652048.2012.7262830265-2048AUT: AMG02212;info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-24T10:13:10Zoai:sapientia.ualg.pt:10400.1/2101Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:56:03.638199Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Natural carriers for application in tuberculosis treatment
title Natural carriers for application in tuberculosis treatment
spellingShingle Natural carriers for application in tuberculosis treatment
Costa, Hugo
Controlled release
Drug delivery
Microparticles
Nanoparticles
Microencapsulation
title_short Natural carriers for application in tuberculosis treatment
title_full Natural carriers for application in tuberculosis treatment
title_fullStr Natural carriers for application in tuberculosis treatment
title_full_unstemmed Natural carriers for application in tuberculosis treatment
title_sort Natural carriers for application in tuberculosis treatment
author Costa, Hugo
author_facet Costa, Hugo
Grenha, Ana
author_role author
author2 Grenha, Ana
author2_role author
dc.contributor.none.fl_str_mv Sapientia
dc.contributor.author.fl_str_mv Costa, Hugo
Grenha, Ana
dc.subject.por.fl_str_mv Controlled release
Drug delivery
Microparticles
Nanoparticles
Microencapsulation
topic Controlled release
Drug delivery
Microparticles
Nanoparticles
Microencapsulation
description Tuberculosis remains the leading cause of preventable deaths worldwide and unsuccessful therapy is mainly due to non-compliance with very prolonged treatments, often associated with severe side-effects. Overcoming this problem demands the introduction of drug carriers releasing the antimicrobial agents in a targeted and sustained manner, allowing reduction in frequency and dosing numbers. Nano and microparticles have taken the forefront of this approach, providing the means for the desired improvement of therapeutic schedules. Natural polymers are strong candidates as matrix forming materials, usually exhibiting biocompatibility, biodegradability, low cost and some technological advantages as compared with synthetic counterparts. In this review, natural particulate carriers developed for tuberculosis therapy are presented, mainly focusing on the use of polysaccharides and lipids. Their effectiveness is discussed taking into account their composition. Finally, considerations on the general potential of natural materials for this application, as well as key factors still to be addressed, are discussed.
publishDate 2012
dc.date.none.fl_str_mv 2012
2012-01-01T00:00:00Z
2013-01-16T13:58:27Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.1/2101
url http://hdl.handle.net/10400.1/2101
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv doi:10.3109/02652048.2012.726283
0265-2048
AUT: AMG02212;
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
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