Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases

Detalhes bibliográficos
Autor(a) principal: Madeira, Maria H.
Data de Publicação: 2015
Outros Autores: Boia, Raquel, Santos, Paulo, Ambrósio, A. Francisco, Santiago, Ana R.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10316/109229
https://doi.org/10.1155/2015/673090
Resumo: Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
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spelling Contribution of microglia-mediated neuroinflammation to retinal degenerative diseasesDiabetic RetinopathyGlaucomaHumansInflammationMacular DegenerationMicrogliaNeurodegenerative DiseasesRetinaRetinal DegenerationRetinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.Hindawi2015info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/109229http://hdl.handle.net/10316/109229https://doi.org/10.1155/2015/673090eng0962-93511466-1861Madeira, Maria H.Boia, RaquelSantos, PauloAmbrósio, A. FranciscoSantiago, Ana R.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-04T09:37:37Zoai:estudogeral.uc.pt:10316/109229Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:25:26.960817Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
title Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
spellingShingle Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
Madeira, Maria H.
Diabetic Retinopathy
Glaucoma
Humans
Inflammation
Macular Degeneration
Microglia
Neurodegenerative Diseases
Retina
Retinal Degeneration
title_short Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
title_full Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
title_fullStr Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
title_full_unstemmed Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
title_sort Contribution of microglia-mediated neuroinflammation to retinal degenerative diseases
author Madeira, Maria H.
author_facet Madeira, Maria H.
Boia, Raquel
Santos, Paulo
Ambrósio, A. Francisco
Santiago, Ana R.
author_role author
author2 Boia, Raquel
Santos, Paulo
Ambrósio, A. Francisco
Santiago, Ana R.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Madeira, Maria H.
Boia, Raquel
Santos, Paulo
Ambrósio, A. Francisco
Santiago, Ana R.
dc.subject.por.fl_str_mv Diabetic Retinopathy
Glaucoma
Humans
Inflammation
Macular Degeneration
Microglia
Neurodegenerative Diseases
Retina
Retinal Degeneration
topic Diabetic Retinopathy
Glaucoma
Humans
Inflammation
Macular Degeneration
Microglia
Neurodegenerative Diseases
Retina
Retinal Degeneration
description Retinal degenerative diseases are major causes of vision loss and blindness worldwide and are characterized by chronic and progressive neuronal loss. One common feature of retinal degenerative diseases and brain neurodegenerative diseases is chronic neuroinflammation. There is growing evidence that retinal microglia, as in the brain, become activated in the course of retinal degenerative diseases, having a pivotal role in the initiation and propagation of the neurodegenerative process. A better understanding of the events elicited and mediated by retinal microglia will contribute to the clarification of disease etiology and might open new avenues for potential therapeutic interventions. This review aims at giving an overview of the roles of microglia-mediated neuroinflammation in major retinal degenerative diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
publishDate 2015
dc.date.none.fl_str_mv 2015
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10316/109229
http://hdl.handle.net/10316/109229
https://doi.org/10.1155/2015/673090
url http://hdl.handle.net/10316/109229
https://doi.org/10.1155/2015/673090
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0962-9351
1466-1861
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Hindawi
publisher.none.fl_str_mv Hindawi
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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