Application of light scattering techniques to nanoparticle characterization and development

Detalhes bibliográficos
Autor(a) principal: Carvalho, Patricia
Data de Publicação: 2018
Outros Autores: Felício, Mário Romão, Santos, Nuno C., Abreu, Sónia Gonçalves, Domingues, Marco
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/37852
Resumo: Copyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
id RCAP_af15a0856a2032a08e20b279db7dfee4
oai_identifier_str oai:repositorio.ul.pt:10451/37852
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Application of light scattering techniques to nanoparticle characterization and developmentNanoparticlesDynamic light scatteringZeta-potentialAntimicrobial peptidesAnticancer peptidesCardiovascular diseasesCopyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.This work was supported by Fundação para a Ciência e a Tecnologia–Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) projects PTDC/BBBBQB/3494/2014 and PTDC/BBB-BMD/6307/2014. This work was also supported by LISBOA-01-0145-FEDER-007391 project, cofunded by FEDER, through POR Lisboa 2020—Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia. PMC, MRF and MMD acknowledge FCT-MCTES fellowships SFRH/BD/108077/2015, SFRH/BD/100517/2014, and SFRH/BPD/122779/2016, respectivelyFrontiers MediaRepositório da Universidade de LisboaCarvalho, PatriciaFelício, Mário RomãoSantos, Nuno C.Abreu, Sónia GonçalvesDomingues, Marco2019-04-04T15:40:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/37852engFront Chem. 2018 Jun 25;6:2372296-264610.3389/fchem.2018.00237info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:35:14Zoai:repositorio.ul.pt:10451/37852Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:51:49.405266Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Application of light scattering techniques to nanoparticle characterization and development
title Application of light scattering techniques to nanoparticle characterization and development
spellingShingle Application of light scattering techniques to nanoparticle characterization and development
Carvalho, Patricia
Nanoparticles
Dynamic light scattering
Zeta-potential
Antimicrobial peptides
Anticancer peptides
Cardiovascular diseases
title_short Application of light scattering techniques to nanoparticle characterization and development
title_full Application of light scattering techniques to nanoparticle characterization and development
title_fullStr Application of light scattering techniques to nanoparticle characterization and development
title_full_unstemmed Application of light scattering techniques to nanoparticle characterization and development
title_sort Application of light scattering techniques to nanoparticle characterization and development
author Carvalho, Patricia
author_facet Carvalho, Patricia
Felício, Mário Romão
Santos, Nuno C.
Abreu, Sónia Gonçalves
Domingues, Marco
author_role author
author2 Felício, Mário Romão
Santos, Nuno C.
Abreu, Sónia Gonçalves
Domingues, Marco
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Carvalho, Patricia
Felício, Mário Romão
Santos, Nuno C.
Abreu, Sónia Gonçalves
Domingues, Marco
dc.subject.por.fl_str_mv Nanoparticles
Dynamic light scattering
Zeta-potential
Antimicrobial peptides
Anticancer peptides
Cardiovascular diseases
topic Nanoparticles
Dynamic light scattering
Zeta-potential
Antimicrobial peptides
Anticancer peptides
Cardiovascular diseases
description Copyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01T00:00:00Z
2019-04-04T15:40:42Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/37852
url http://hdl.handle.net/10451/37852
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Front Chem. 2018 Jun 25;6:237
2296-2646
10.3389/fchem.2018.00237
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799134453972336640

Registros relacionados