Application of light scattering techniques to nanoparticle characterization and development
Autor(a) principal: | |
---|---|
Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10451/37852 |
Resumo: | Copyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
id |
RCAP_af15a0856a2032a08e20b279db7dfee4 |
---|---|
oai_identifier_str |
oai:repositorio.ul.pt:10451/37852 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Application of light scattering techniques to nanoparticle characterization and developmentNanoparticlesDynamic light scatteringZeta-potentialAntimicrobial peptidesAnticancer peptidesCardiovascular diseasesCopyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Over the years, the scientific importance of nanoparticles for biomedical applications has increased. The high stability and biocompatibility, together with the low toxicity of the nanoparticles developed lead to their use as targeted drug delivery systems, bioimaging systems, and biosensors. The wide range of nanoparticles size, from 10 nm to 1 μm, as well as their optical properties, allow them to be studied using microscopy and spectroscopy techniques. In order to be effectively used, the physicochemical properties of nanoparticle formulations need to be taken into account, namely, particle size, surface charge distribution, surface derivatization and/or loading capacity, and related interactions. These properties need to be optimized considering the final nanoparticle intended biodistribution and target. In this review, we cover light scattering based techniques, namely dynamic light scattering and zeta-potential, used for the physicochemical characterization of nanoparticles. Dynamic light scattering is used to measure nanoparticles size, but also to evaluate their stability over time in suspension, at different pH and temperature conditions. Zeta-potential is used to characterize nanoparticles surface charge, obtaining information about their stability and surface interaction with other molecules. In this review, we focus on nanoparticle characterization and application in infection, cancer and cardiovascular diseases.This work was supported by Fundação para a Ciência e a Tecnologia–Ministério da Ciência, Tecnologia e Ensino Superior (FCT-MCTES, Portugal) projects PTDC/BBBBQB/3494/2014 and PTDC/BBB-BMD/6307/2014. This work was also supported by LISBOA-01-0145-FEDER-007391 project, cofunded by FEDER, through POR Lisboa 2020—Programa Operacional Regional de Lisboa, PORTUGAL 2020, and Fundação para a Ciência e a Tecnologia. PMC, MRF and MMD acknowledge FCT-MCTES fellowships SFRH/BD/108077/2015, SFRH/BD/100517/2014, and SFRH/BPD/122779/2016, respectivelyFrontiers MediaRepositório da Universidade de LisboaCarvalho, PatriciaFelício, Mário RomãoSantos, Nuno C.Abreu, Sónia GonçalvesDomingues, Marco2019-04-04T15:40:42Z20182018-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/37852engFront Chem. 2018 Jun 25;6:2372296-264610.3389/fchem.2018.00237info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:35:14Zoai:repositorio.ul.pt:10451/37852Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:51:49.405266Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Application of light scattering techniques to nanoparticle characterization and development |
title |
Application of light scattering techniques to nanoparticle characterization and development |
spellingShingle |
Application of light scattering techniques to nanoparticle characterization and development Carvalho, Patricia Nanoparticles Dynamic light scattering Zeta-potential Antimicrobial peptides Anticancer peptides Cardiovascular diseases |
title_short |
Application of light scattering techniques to nanoparticle characterization and development |
title_full |
Application of light scattering techniques to nanoparticle characterization and development |
title_fullStr |
Application of light scattering techniques to nanoparticle characterization and development |
title_full_unstemmed |
Application of light scattering techniques to nanoparticle characterization and development |
title_sort |
Application of light scattering techniques to nanoparticle characterization and development |
author |
Carvalho, Patricia |
author_facet |
Carvalho, Patricia Felício, Mário Romão Santos, Nuno C. Abreu, Sónia Gonçalves Domingues, Marco |
author_role |
author |
author2 |
Felício, Mário Romão Santos, Nuno C. Abreu, Sónia Gonçalves Domingues, Marco |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
dc.contributor.author.fl_str_mv |
Carvalho, Patricia Felício, Mário Romão Santos, Nuno C. Abreu, Sónia Gonçalves Domingues, Marco |
dc.subject.por.fl_str_mv |
Nanoparticles Dynamic light scattering Zeta-potential Antimicrobial peptides Anticancer peptides Cardiovascular diseases |
topic |
Nanoparticles Dynamic light scattering Zeta-potential Antimicrobial peptides Anticancer peptides Cardiovascular diseases |
description |
Copyright © 2018 Carvalho, Felício, Santos, Gonçalves and Domingues. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018 2018-01-01T00:00:00Z 2019-04-04T15:40:42Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/37852 |
url |
http://hdl.handle.net/10451/37852 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Front Chem. 2018 Jun 25;6:237 2296-2646 10.3389/fchem.2018.00237 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799134453972336640 |