Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad

Detalhes bibliográficos
Autor(a) principal: Almeida, José Rafael
Data de Publicação: 2023
Outros Autores: Gomes, Ana S. M., Mendes, Bruno, Aguiar, Luísa, Ferreira, Mariana, Brioschi, Mariana Borges Costa, Duarte, Denise, Nogueira, Fátima, Cortes, Sofia, Salazar-Valenzuela, David, Miguel, Danilo C., Teixeira, Cátia A. S., Gameiro, Paula, Gomes, Paula
Tipo de documento: Outros
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/153925
Resumo: Funding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019.The authors further thank FCT/MCTES for supporting Research Units LAQV-REQUIMTE (UIDB/50006/2020), GHTM (UID/Multi/04413/2020). Publisher Copyright: © 2023 The Authors
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spelling Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triadPeptidesSnake venomsVector-borne protozoan infectionsRM Therapeutics. PharmacologyQR MicrobiologyMolecular BiologyStructural BiologyBiochemistrySDG 3 - Good Health and Well-beingSDG 9 - Industry, Innovation, and InfrastructureFunding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019.The authors further thank FCT/MCTES for supporting Research Units LAQV-REQUIMTE (UIDB/50006/2020), GHTM (UID/Multi/04413/2020). Publisher Copyright: © 2023 The AuthorsMalaria, leishmaniasis and Chagas disease are vector-borne protozoal infections with a disproportionately high impact on the most fragile societies in the world, and despite malaria-focused research gained momentum in the past two decades, both trypanosomiases and leishmaniases remain neglected tropical diseases. Affordable effective drugs remain the mainstay of tackling this burden, but toxicicty, inneficiency against later stage disease, and drug resistance issues are serious shortcomings. One strategy to overcome these hurdles is to get new therapeutics or inspiration in nature. Indeed, snake venoms have been recognized as valuable sources of biomacromolecules, like peptides and proteins, with antiprotozoal activity. This review highlights major snake venom components active against at least one of the three aforementioned diseases, which include phospholipases A2, metalloproteases, L-amino acid oxidases, lectins, and oligopeptides. The relevance of this repertoire of biomacromolecules and the bottlenecks in their clinical translation are discussed considering approaches that should increase the success rate in this arduous task. Overall, this review underlines how venom-derived biomacromolecules could lead to pioneering antiprotozoal treatments and how the drug landscape for neglected diseases may be revolutionized by a closer look at venoms. Further investigations on poorly studied venoms is needed and could add new therapeutics to the pipeline.Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)RUNAlmeida, José RafaelGomes, Ana S. M.Mendes, BrunoAguiar, LuísaFerreira, MarianaBrioschi, Mariana Borges CostaDuarte, DeniseNogueira, FátimaCortes, SofiaSalazar-Valenzuela, DavidMiguel, Danilo C.Teixeira, Cátia A. S.Gameiro, PaulaGomes, Paula2023-06-14T22:19:41Z2023-07-012023-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttp://hdl.handle.net/10362/153925eng0141-8130PURE: 61132781https://doi.org/10.1016/j.ijbiomac.2023.124745info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-06-24T01:35:03Zoai:run.unl.pt:10362/153925Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-06-24T01:35:03Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
title Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
spellingShingle Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
Almeida, José Rafael
Peptides
Snake venoms
Vector-borne protozoan infections
RM Therapeutics. Pharmacology
QR Microbiology
Molecular Biology
Structural Biology
Biochemistry
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
title_short Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
title_full Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
title_fullStr Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
title_full_unstemmed Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
title_sort Unlocking the potential of snake venom-based molecules against the malaria, Chagas disease, and leishmaniasis triad
author Almeida, José Rafael
author_facet Almeida, José Rafael
Gomes, Ana S. M.
Mendes, Bruno
Aguiar, Luísa
Ferreira, Mariana
Brioschi, Mariana Borges Costa
Duarte, Denise
Nogueira, Fátima
Cortes, Sofia
Salazar-Valenzuela, David
Miguel, Danilo C.
Teixeira, Cátia A. S.
Gameiro, Paula
Gomes, Paula
author_role author
author2 Gomes, Ana S. M.
Mendes, Bruno
Aguiar, Luísa
Ferreira, Mariana
Brioschi, Mariana Borges Costa
Duarte, Denise
Nogueira, Fátima
Cortes, Sofia
Salazar-Valenzuela, David
Miguel, Danilo C.
Teixeira, Cátia A. S.
Gameiro, Paula
Gomes, Paula
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Global Health and Tropical Medicine (GHTM)
Instituto de Higiene e Medicina Tropical (IHMT)
Vector borne diseases and pathogens (VBD)
RUN
dc.contributor.author.fl_str_mv Almeida, José Rafael
Gomes, Ana S. M.
Mendes, Bruno
Aguiar, Luísa
Ferreira, Mariana
Brioschi, Mariana Borges Costa
Duarte, Denise
Nogueira, Fátima
Cortes, Sofia
Salazar-Valenzuela, David
Miguel, Danilo C.
Teixeira, Cátia A. S.
Gameiro, Paula
Gomes, Paula
dc.subject.por.fl_str_mv Peptides
Snake venoms
Vector-borne protozoan infections
RM Therapeutics. Pharmacology
QR Microbiology
Molecular Biology
Structural Biology
Biochemistry
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
topic Peptides
Snake venoms
Vector-borne protozoan infections
RM Therapeutics. Pharmacology
QR Microbiology
Molecular Biology
Structural Biology
Biochemistry
SDG 3 - Good Health and Well-being
SDG 9 - Industry, Innovation, and Infrastructure
description Funding Information: This work received financial support from PT national funds ( FCT/MCTES , Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019 . Funding Information: This work received financial support from PT national funds (FCT/MCTES, Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior) through the project CIRCNA/BRB/0281/2019.The authors further thank FCT/MCTES for supporting Research Units LAQV-REQUIMTE (UIDB/50006/2020), GHTM (UID/Multi/04413/2020). Publisher Copyright: © 2023 The Authors
publishDate 2023
dc.date.none.fl_str_mv 2023-06-14T22:19:41Z
2023-07-01
2023-07-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/other
format other
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/153925
url http://hdl.handle.net/10362/153925
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0141-8130
PURE: 61132781
https://doi.org/10.1016/j.ijbiomac.2023.124745
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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