Challenges in matrix metalloproteinases inhibition

Detalhes bibliográficos
Autor(a) principal: Laronha, Helena
Data de Publicação: 2020
Outros Autores: Carpinteiro, Inês, Portugal, Jaime, Azul, Ana, Polido, Mário, Petrova, Krasimira T., Salema-Oom, Madalena, Caldeira, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.26/33754
Resumo: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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spelling Challenges in matrix metalloproteinases inhibitionMatrix metalloproteinasesTIMPSynthetic inhibitorsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Matrix metalloproteinases are enzymes that degrade the extracellular matrix. They have different substrates but similar structural organization. Matrix metalloproteinases are involved in many physiological and pathological processes and there is a need to develop inhibitors for these enzymes in order to modulate the degradation of the extracellular matrix (ECM). There exist two classes of inhibitors: endogenous and synthetics. The development of synthetic inhibitors remains a great challenge due to the low selectivity and specificity, side effects in clinical trials, and instability. An extensive review of currently reported synthetic inhibitors and description of their properties is presented.MDPIRepositório ComumLaronha, HelenaCarpinteiro, InêsPortugal, JaimeAzul, AnaPolido, MárioPetrova, Krasimira T.Salema-Oom, MadalenaCaldeira, Jorge2020-10-22T11:27:11Z2020-05-01T00:00:00Z2020-05-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.26/33754engLaronha, H.; Carpinteiro, I.; Portugal, J.; Azul, A.; Polido, M.; Petrova, K.T.; Salema-Oom, M.; Caldeira, J. Challenges in Matrix Metalloproteinases Inhibition. Biomolecules 2020, 10, 717.2218-273Xdoi.org/10.3390/biom10050717info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-10-06T14:54:09Zoai:comum.rcaap.pt:10400.26/33754Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:09:55.530916Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Challenges in matrix metalloproteinases inhibition
title Challenges in matrix metalloproteinases inhibition
spellingShingle Challenges in matrix metalloproteinases inhibition
Laronha, Helena
Matrix metalloproteinases
TIMP
Synthetic inhibitors
title_short Challenges in matrix metalloproteinases inhibition
title_full Challenges in matrix metalloproteinases inhibition
title_fullStr Challenges in matrix metalloproteinases inhibition
title_full_unstemmed Challenges in matrix metalloproteinases inhibition
title_sort Challenges in matrix metalloproteinases inhibition
author Laronha, Helena
author_facet Laronha, Helena
Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Caldeira, Jorge
author_role author
author2 Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Caldeira, Jorge
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Comum
dc.contributor.author.fl_str_mv Laronha, Helena
Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Caldeira, Jorge
dc.subject.por.fl_str_mv Matrix metalloproteinases
TIMP
Synthetic inhibitors
topic Matrix metalloproteinases
TIMP
Synthetic inhibitors
description This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
publishDate 2020
dc.date.none.fl_str_mv 2020-10-22T11:27:11Z
2020-05-01T00:00:00Z
2020-05-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.26/33754
url http://hdl.handle.net/10400.26/33754
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Laronha, H.; Carpinteiro, I.; Portugal, J.; Azul, A.; Polido, M.; Petrova, K.T.; Salema-Oom, M.; Caldeira, J. Challenges in Matrix Metalloproteinases Inhibition. Biomolecules 2020, 10, 717.
2218-273X
doi.org/10.3390/biom10050717
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
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instacron:RCAAP
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