Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations

Detalhes bibliográficos
Autor(a) principal: Laronha, Helena
Data de Publicação: 2021
Outros Autores: Carpinteiro, Inês, Portugal, Jaime, Azul, Ana, Polido, Mário, Petrova, Krasimira T., Salema-Oom, Madalena, Barahona, Isabel, Caldeira, Jorge
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/145949
Resumo: Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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spelling Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorationsCytotoxicityInhibitors of matrix metalloproteinasesMatrixMetalloproteinasesMedicine (miscellaneous)Biochemistry, Genetics and Molecular Biology(all)Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.Collagen cleavage by matrix metalloproteinase (MMP) is considered a major cause of dental resins long term failure. Most MMP inhibitors display significant toxicity and are unsuitable for dental resins’ applications. Here we report a study of a new class of inhibitors that display the unique property of being co-polymerizable with other vinyl compounds present in commercial dental resins, limiting their release and potential toxicity. Computational affinity towards the active site of different MMP-1;-2;-8;-9 and-13 of several compounds showed interesting properties and were synthesized. These free compounds were tested concerning their toxicity upon contact with two different cell types, with no substantial decrease in cell viability at high concentrations. Even so, compound’s safety can be further improved upon copolymerization with commercial dental resins, limiting their release.UCIBIO - Applied Molecular Biosciences UnitLAQV@REQUIMTERUNLaronha, HelenaCarpinteiro, InêsPortugal, JaimeAzul, AnaPolido, MárioPetrova, Krasimira T.Salema-Oom, MadalenaBarahona, IsabelCaldeira, Jorge2022-12-02T22:14:06Z2021-03-312021-03-31T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article20application/pdfhttp://hdl.handle.net/10362/145949eng2227-9059PURE: 45575058https://doi.org/10.3390/biomedicines9040366info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:26:48Zoai:run.unl.pt:10362/145949Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:52:21.682055Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
title Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
spellingShingle Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
Laronha, Helena
Cytotoxicity
Inhibitors of matrix metalloproteinases
Matrix
Metalloproteinases
Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
title_short Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
title_full Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
title_fullStr Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
title_full_unstemmed Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
title_sort Polymerizable matrix metalloproteinases’ inhibitors with potential application for dental restorations
author Laronha, Helena
author_facet Laronha, Helena
Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Barahona, Isabel
Caldeira, Jorge
author_role author
author2 Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Barahona, Isabel
Caldeira, Jorge
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv UCIBIO - Applied Molecular Biosciences Unit
LAQV@REQUIMTE
RUN
dc.contributor.author.fl_str_mv Laronha, Helena
Carpinteiro, Inês
Portugal, Jaime
Azul, Ana
Polido, Mário
Petrova, Krasimira T.
Salema-Oom, Madalena
Barahona, Isabel
Caldeira, Jorge
dc.subject.por.fl_str_mv Cytotoxicity
Inhibitors of matrix metalloproteinases
Matrix
Metalloproteinases
Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
topic Cytotoxicity
Inhibitors of matrix metalloproteinases
Matrix
Metalloproteinases
Medicine (miscellaneous)
Biochemistry, Genetics and Molecular Biology(all)
description Funding Information: This research was funded by A Molecular View of Dental Restoration, grant number PTDC/SAU-BMA/122444/2010 and by Molecular Design for Dental Restauration, grant number SAICT-POL/24288/2016. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
publishDate 2021
dc.date.none.fl_str_mv 2021-03-31
2021-03-31T00:00:00Z
2022-12-02T22:14:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/145949
url http://hdl.handle.net/10362/145949
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 2227-9059
PURE: 45575058
https://doi.org/10.3390/biomedicines9040366
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 20
application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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