HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium

Detalhes bibliográficos
Autor(a) principal: Tavares, Ana
Data de Publicação: 2022
Outros Autores: Aimonen, Kukka, Ndaw, Sophie, Fučić, Aleksandra, Catalán, Julia, Duca, Radu Corneliu, Godderis, Lode, Gomes, Bruno C., Janasik, Beata, Ladeira, Carina, Louro, Henriqueta, Namorado, Sónia, Nieuwenhuyse, An Van, Norppa, Hannu, Scheepers, Paul, Ventura, Célia, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Santonen, Tiina, Silva, M.J., on behalf of the HBM4EU Chromates Study Team
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8293
Resumo: This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?
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spelling HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent ChromiumHexavalent ChromiumChromiumBiomonitoringEffect BiomarkersMicronuclei8-OHdGMDAOccupational ExposureComet AssayOxidative StressEnvironmental GenotoxicityEuropean Human Biomonitoring InitiativeHBM4EUEuropeCrómioExposição OcupacionalMicronúcleosBiomonitorizaçaoDeterminantes da Saúde e da DoençaEstados de Saúde e de DoençaBiomarcadores de EfeitoGenotoxicidade AmbientalEuropaThis article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?A study was conducted within the European Human Biomonitoring Initiative (HBM4EU) to characterize occupational exposure to Cr(VI). Herein we present the results of biomarkers of genotoxicity and oxidative stress, including micronucleus analysis in lymphocytes and reticulocytes, the comet assay in whole blood, and malondialdehyde and 8-oxo-2'-deoxyguanosine in urine. Workers from several Cr(VI)-related industrial activities and controls from industrial (within company) and non-industrial (outwith company) environments were included. The significantly increased genotoxicity (p = 0.03 for MN in lymphocytes and reticulocytes; p < 0.001 for comet assay data) and oxidative stress levels (p = 0.007 and p < 0.001 for MDA and 8-OHdG levels in pre-shift urine samples, respectively) that were detected in the exposed workers over the outwith company controls suggest that Cr(VI) exposure might still represent a health risk, particularly, for chrome painters and electrolytic bath platers, despite the low Cr exposure. The within-company controls displayed DNA and chromosomal damage levels that were comparable to those of the exposed group, highlighting the relevance of considering all industry workers as potentially exposed. The use of effect biomarkers proved their capacity to detect the early biological effects from low Cr(VI) exposure, and to contribute to identifying subgroups that are at higher risk. Overall, this study reinforces the need for further re-evaluation of the occupational exposure limit and better application of protection measures. However, it also raised some additional questions and unexplained inconsistencies that need follow-up studies to be clarified.This project has received funding from the European Union’s Horizon 2020 Research and Innovation Programme under grant agreement no. 733032 and received co-funding from the author’s organizations and/or Ministries.MDPIRepositório Científico do Instituto Nacional de SaúdeTavares, AnaAimonen, KukkaNdaw, SophieFučić, AleksandraCatalán, JuliaDuca, Radu CorneliuGodderis, LodeGomes, Bruno C.Janasik, BeataLadeira, CarinaLouro, HenriquetaNamorado, SóniaNieuwenhuyse, An VanNorppa, HannuScheepers, PaulVentura, CéliaVerdonck, JelleViegas, SusanaWasowicz, WojciechSantonen, TiinaSilva, M.J.on behalf of the HBM4EU Chromates Study Team2022-11-02T13:55:04Z2022-08-182022-08-18T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8293engToxics. 2022 Aug 18;10(8):483. doi: 10.3390/toxics100804832305-630410.3390/toxics10080483info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:42:31Zoai:repositorio.insa.pt:10400.18/8293Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:42:59.497986Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
title HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
spellingShingle HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
Tavares, Ana
Hexavalent Chromium
Chromium
Biomonitoring
Effect Biomarkers
Micronuclei
8-OHdG
MDA
Occupational Exposure
Comet Assay
Oxidative Stress
Environmental Genotoxicity
European Human Biomonitoring Initiative
HBM4EU
Europe
Crómio
Exposição Ocupacional
Micronúcleos
Biomonitorizaçao
Determinantes da Saúde e da Doença
Estados de Saúde e de Doença
Biomarcadores de Efeito
Genotoxicidade Ambiental
Europa
title_short HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
title_full HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
title_fullStr HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
title_full_unstemmed HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
title_sort HBM4EU Chromates Study - Genotoxicity and Oxidative Stress Biomarkers in Workers Exposed to Hexavalent Chromium
author Tavares, Ana
author_facet Tavares, Ana
Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, M.J.
on behalf of the HBM4EU Chromates Study Team
author_role author
author2 Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, M.J.
on behalf of the HBM4EU Chromates Study Team
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Tavares, Ana
Aimonen, Kukka
Ndaw, Sophie
Fučić, Aleksandra
Catalán, Julia
Duca, Radu Corneliu
Godderis, Lode
Gomes, Bruno C.
Janasik, Beata
Ladeira, Carina
Louro, Henriqueta
Namorado, Sónia
Nieuwenhuyse, An Van
Norppa, Hannu
Scheepers, Paul
Ventura, Célia
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Santonen, Tiina
Silva, M.J.
on behalf of the HBM4EU Chromates Study Team
dc.subject.por.fl_str_mv Hexavalent Chromium
Chromium
Biomonitoring
Effect Biomarkers
Micronuclei
8-OHdG
MDA
Occupational Exposure
Comet Assay
Oxidative Stress
Environmental Genotoxicity
European Human Biomonitoring Initiative
HBM4EU
Europe
Crómio
Exposição Ocupacional
Micronúcleos
Biomonitorizaçao
Determinantes da Saúde e da Doença
Estados de Saúde e de Doença
Biomarcadores de Efeito
Genotoxicidade Ambiental
Europa
topic Hexavalent Chromium
Chromium
Biomonitoring
Effect Biomarkers
Micronuclei
8-OHdG
MDA
Occupational Exposure
Comet Assay
Oxidative Stress
Environmental Genotoxicity
European Human Biomonitoring Initiative
HBM4EU
Europe
Crómio
Exposição Ocupacional
Micronúcleos
Biomonitorizaçao
Determinantes da Saúde e da Doença
Estados de Saúde e de Doença
Biomarcadores de Efeito
Genotoxicidade Ambiental
Europa
description This article belongs to the Special Issue Analysis of Human Biomonitoring Data and Risk Assessment of Human Exposure to Environmental Chemicals: What Do We Learn for Prevention?
publishDate 2022
dc.date.none.fl_str_mv 2022-11-02T13:55:04Z
2022-08-18
2022-08-18T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8293
url http://hdl.handle.net/10400.18/8293
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxics. 2022 Aug 18;10(8):483. doi: 10.3390/toxics10080483
2305-6304
10.3390/toxics10080483
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instacron_str RCAAP
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collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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