Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery

Detalhes bibliográficos
Autor(a) principal: Guimarães, Rafaela
Data de Publicação: 2020
Outros Autores: Rodrigues, Ana Carolina Félix, Moreira, André F., Correia, I.J.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.6/10283
Resumo: The application of nanomaterials is regarded nowadays as a highly promising approach for overcoming the limitations of the currently available cancer treatments, contributing for the creation of more effective, precise, and safer therapies. In the last years, organosilica nanoparticles arisen as alternatives to the most common mesoporous silica nanoparticles. The organosilica nanoparticles combine the advantages of the mesoporous silica, such as structural stability and mesoporous structure, with the increased biocompatibility and biodegradability of organic materials. Therefore, the variety of organic bridges that can be incorporated into the silica matrix allowed the development of new and exciting compositions, properties, and functions for improving the therapeutic effectiveness of the anticancer nanomedicines. In this review, the strategies that have been explored to create stimuli-responsive organosilica-based drug delivery systems are highlighted, describing the practical approaches and mechanisms controlling the drug release. Additionally, the organosilica nanoparticles surface modifications aimed for increasing the blood circulation time and the tumor targeting are also described.
id RCAP_6237e6971fabb852e8e9126ab0427ea3
oai_identifier_str oai:ubibliorum.ubi.pt:10400.6/10283
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug deliveryMesoporous organosilica nanoparticlesDrug deliveryCancer therapyNanomedicineStimuli responsiveThe application of nanomaterials is regarded nowadays as a highly promising approach for overcoming the limitations of the currently available cancer treatments, contributing for the creation of more effective, precise, and safer therapies. In the last years, organosilica nanoparticles arisen as alternatives to the most common mesoporous silica nanoparticles. The organosilica nanoparticles combine the advantages of the mesoporous silica, such as structural stability and mesoporous structure, with the increased biocompatibility and biodegradability of organic materials. Therefore, the variety of organic bridges that can be incorporated into the silica matrix allowed the development of new and exciting compositions, properties, and functions for improving the therapeutic effectiveness of the anticancer nanomedicines. In this review, the strategies that have been explored to create stimuli-responsive organosilica-based drug delivery systems are highlighted, describing the practical approaches and mechanisms controlling the drug release. Additionally, the organosilica nanoparticles surface modifications aimed for increasing the blood circulation time and the tumor targeting are also described.ElsevieruBibliorumGuimarães, RafaelaRodrigues, Ana Carolina FélixMoreira, André F.Correia, I.J.2021-06-10T00:30:14Z2020-03-062020-03-06T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/10283eng10.1016/j.phrs.2020.104742info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-20T02:30:37Zoai:ubibliorum.ubi.pt:10400.6/10283Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:50:17.077033Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
title Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
spellingShingle Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
Guimarães, Rafaela
Mesoporous organosilica nanoparticles
Drug delivery
Cancer therapy
Nanomedicine
Stimuli responsive
title_short Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
title_full Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
title_fullStr Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
title_full_unstemmed Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
title_sort Overview of stimuli-responsive mesoporous organosilica nanocarriers for drug delivery
author Guimarães, Rafaela
author_facet Guimarães, Rafaela
Rodrigues, Ana Carolina Félix
Moreira, André F.
Correia, I.J.
author_role author
author2 Rodrigues, Ana Carolina Félix
Moreira, André F.
Correia, I.J.
author2_role author
author
author
dc.contributor.none.fl_str_mv uBibliorum
dc.contributor.author.fl_str_mv Guimarães, Rafaela
Rodrigues, Ana Carolina Félix
Moreira, André F.
Correia, I.J.
dc.subject.por.fl_str_mv Mesoporous organosilica nanoparticles
Drug delivery
Cancer therapy
Nanomedicine
Stimuli responsive
topic Mesoporous organosilica nanoparticles
Drug delivery
Cancer therapy
Nanomedicine
Stimuli responsive
description The application of nanomaterials is regarded nowadays as a highly promising approach for overcoming the limitations of the currently available cancer treatments, contributing for the creation of more effective, precise, and safer therapies. In the last years, organosilica nanoparticles arisen as alternatives to the most common mesoporous silica nanoparticles. The organosilica nanoparticles combine the advantages of the mesoporous silica, such as structural stability and mesoporous structure, with the increased biocompatibility and biodegradability of organic materials. Therefore, the variety of organic bridges that can be incorporated into the silica matrix allowed the development of new and exciting compositions, properties, and functions for improving the therapeutic effectiveness of the anticancer nanomedicines. In this review, the strategies that have been explored to create stimuli-responsive organosilica-based drug delivery systems are highlighted, describing the practical approaches and mechanisms controlling the drug release. Additionally, the organosilica nanoparticles surface modifications aimed for increasing the blood circulation time and the tumor targeting are also described.
publishDate 2020
dc.date.none.fl_str_mv 2020-03-06
2020-03-06T00:00:00Z
2021-06-10T00:30:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.6/10283
url http://hdl.handle.net/10400.6/10283
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1016/j.phrs.2020.104742
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799136393090301953