The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation

Detalhes bibliográficos
Autor(a) principal: Raposo, Ana Cláudia
Data de Publicação: 2021
Outros Autores: Casanova, Miguel, Gendrel, Anne-Valerie, da Rocha, Simão T.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/50688
Resumo: © 2021 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
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spelling The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivationX-chromosome inactivationChromatinEpigeneticslncRNATandem repeat© 2021 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).X-inactive-specific transcript (Xist) is a long non-coding RNA (lncRNA) essential for X-chromosome inactivation (XCI) in female placental mammals. Thirty years after its discovery, it is still puzzling how this lncRNA triggers major structural and transcriptional changes leading to the stable silencing of an entire chromosome. Recently, a series of studies in mouse cells have uncovered domains of functional specialization within Xist mapping to conserved tandem repeat regions, known as Repeats A-to-F. These functional domains interact with various RNA binding proteins (RBPs) and fold into distinct RNA structures to execute specific tasks in a synergistic and coordinated manner during the inactivation process. This modular organization of Xist is mostly conserved in humans, but recent data point towards differences regarding functional specialization of the tandem repeats between the two species. In this review, we summarize the recent progress on understanding the role of Xist repetitive blocks and their involvement in the molecular mechanisms underlying XCI. We also discuss these findings in the light of the similarities and differences between mouse and human Xist.This work was supported by Fundação para a Ciência e Tecnologia (FCT)/Ministério da Ciência, Tecnologia e Ensino Superior (MCTES) through the project grants PTDC/BIA-MOL/29320/2017 (S.T.d.R. and A.C.R.), and PTDC/BTM-TEC/28534/2017 (M.C.). S.T.d.R. and A.-V. G. are supported by assistant research contracts from FCT/MCTES (CEECIND/01234/2017 and CEECIND/02085/2018, respectively; A.C.R. is supported by a PhD fellowship from FCT/MCTES (SFRH/BD/137099/2018).Portlands PressRepositório da Universidade de LisboaRaposo, Ana CláudiaCasanova, MiguelGendrel, Anne-Valerieda Rocha, Simão T.2022-01-04T14:01:07Z20212021-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/50688engBiochem Soc Trans. 2021 Dec 17;49(6):2549-25600300-512710.1042/BST202102531470-8752info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:54:54Zoai:repositorio.ul.pt:10451/50688Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:02:02.101580Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
title The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
spellingShingle The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
Raposo, Ana Cláudia
X-chromosome inactivation
Chromatin
Epigenetics
lncRNA
Tandem repeat
title_short The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
title_full The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
title_fullStr The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
title_full_unstemmed The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
title_sort The tandem repeat modules of Xist lncRNA: a swiss army knife for the control of X-chromosome inactivation
author Raposo, Ana Cláudia
author_facet Raposo, Ana Cláudia
Casanova, Miguel
Gendrel, Anne-Valerie
da Rocha, Simão T.
author_role author
author2 Casanova, Miguel
Gendrel, Anne-Valerie
da Rocha, Simão T.
author2_role author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Raposo, Ana Cláudia
Casanova, Miguel
Gendrel, Anne-Valerie
da Rocha, Simão T.
dc.subject.por.fl_str_mv X-chromosome inactivation
Chromatin
Epigenetics
lncRNA
Tandem repeat
topic X-chromosome inactivation
Chromatin
Epigenetics
lncRNA
Tandem repeat
description © 2021 The Author(s) This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY).
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-01-01T00:00:00Z
2022-01-04T14:01:07Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/50688
url http://hdl.handle.net/10451/50688
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Biochem Soc Trans. 2021 Dec 17;49(6):2549-2560
0300-5127
10.1042/BST20210253
1470-8752
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Portlands Press
publisher.none.fl_str_mv Portlands Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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