Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs

Detalhes bibliográficos
Autor(a) principal: Escobar, Carlos
Data de Publicação: 2015
Outros Autores: Pateira, Sara, Lobo, Elsa, Lobo, Lis, Teodosio, Rosa, Dias, Fernanda, Fernandes, Natercia, Arez, Ana Paula, Varandas, Luis, Nogueira, Fatima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: https://doi.org/10.1371/journal.pone.0119215
Resumo: PMID: 25789669 WOS:000351425400072
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spelling Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTsGeneticsParasitologyInfectious DiseasesSDG 3 - Good Health and Well-beingPMID: 25789669 WOS:000351425400072We report the presence of SNPs in Plasmodium falciparum K13-propeller gene in two African countries, Angola and Mozambique, where malaria is a serious public health problem. Samples were collected before and after ACT introduction as first-line treatment. In each country 50 samples collected before and 50 after ACT introduction were analysed. A total of three different mutations (R471R and R575R in Angola and V494I in Mozambique) were identified in five samples, all collected after the introduction of ACT. The R471R mutation detected in Angola has already been reported in Africa (DR-Congo and Gabon). However, the mutations R575R (Angola) and V494I (Mozambique), have never been reported. V494I is adjacent to the known K13 resistance-associated mutation Y493H, although functional analysis did not predict a deleterious effect on protein function.Instituto de Higiene e Medicina Tropical (IHMT)Vector borne diseases and pathogens (VBD)Global Health and Tropical Medicine (GHTM)RUNEscobar, CarlosPateira, SaraLobo, ElsaLobo, LisTeodosio, RosaDias, FernandaFernandes, NaterciaArez, Ana PaulaVarandas, LuisNogueira, Fatima2018-05-14T22:01:38Z2015-03-192015-03-19T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1371/journal.pone.0119215eng1932-6203PURE: 1662900http://www.scopus.com/inward/record.url?scp=84925727402&partnerID=8YFLogxKhttps://doi.org/10.1371/journal.pone.0119215info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-05-22T17:32:50Zoai:run.unl.pt:10362/36928Portal AgregadorONGhttps://www.rcaap.pt/oai/openairemluisa.alvim@gmail.comopendoar:71602024-05-22T17:32:50Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
title Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
spellingShingle Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
Escobar, Carlos
Genetics
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
title_short Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
title_full Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
title_fullStr Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
title_full_unstemmed Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
title_sort Polymorphisms in Plasmodium falciparum K13-propeller in Angola and Mozambique after the introduction of the ACTs
author Escobar, Carlos
author_facet Escobar, Carlos
Pateira, Sara
Lobo, Elsa
Lobo, Lis
Teodosio, Rosa
Dias, Fernanda
Fernandes, Natercia
Arez, Ana Paula
Varandas, Luis
Nogueira, Fatima
author_role author
author2 Pateira, Sara
Lobo, Elsa
Lobo, Lis
Teodosio, Rosa
Dias, Fernanda
Fernandes, Natercia
Arez, Ana Paula
Varandas, Luis
Nogueira, Fatima
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Instituto de Higiene e Medicina Tropical (IHMT)
Vector borne diseases and pathogens (VBD)
Global Health and Tropical Medicine (GHTM)
RUN
dc.contributor.author.fl_str_mv Escobar, Carlos
Pateira, Sara
Lobo, Elsa
Lobo, Lis
Teodosio, Rosa
Dias, Fernanda
Fernandes, Natercia
Arez, Ana Paula
Varandas, Luis
Nogueira, Fatima
dc.subject.por.fl_str_mv Genetics
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
topic Genetics
Parasitology
Infectious Diseases
SDG 3 - Good Health and Well-being
description PMID: 25789669 WOS:000351425400072
publishDate 2015
dc.date.none.fl_str_mv 2015-03-19
2015-03-19T00:00:00Z
2018-05-14T22:01:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1371/journal.pone.0119215
url https://doi.org/10.1371/journal.pone.0119215
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 1932-6203
PURE: 1662900
http://www.scopus.com/inward/record.url?scp=84925727402&partnerID=8YFLogxK
https://doi.org/10.1371/journal.pone.0119215
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv mluisa.alvim@gmail.com
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